4ZWG

Crystal structure of the GTP-dATP-bound catalytic core of SAMHD1 phosphomimetic T592E mutant

Summary for 4ZWG

• Entry DOI: 10.2210/pdb4zwg/pdb
• Related: 4zwe
• Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: phosphorylation, tetramer stability, dntpase, hiv-1 restriction, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 244648.15

Authors

Tang, C.,Ji, X.,Xiong, Y. (deposition date: 2015-05-19, release date: 2015-09-02, Last modification date: 2023-09-27)

• Primary citation: Tang, C.,Ji, X.,Wu, L.,Xiong, Y.; Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.; J.Biol.Chem., 290:26352-26359, 2015; PubMed: 26294762; DOI: 10.1074/jbc.M115.677435

Experimental method

X-RAY DIFFRACTION (2.3 Å)