4ZWG
Crystal structure of the GTP-dATP-bound catalytic core of SAMHD1 phosphomimetic T592E mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 514 | 59632.2 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1 |
| 2 | E, G, K, M, N... (A, B, C, D) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 8 | Chemie (DTP) | |||
| 3 | F, J, L, P (A, B, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) | |||
| 4 | H, I, O, R (A, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 206 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 113 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Arg 206 | His 206 | conflict |
| Asn 207 | Asp 207 | conflict |
| Glu 592 | Thr 592 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 238528.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 6119.4 | |
| All* | Total formula weight | 244648.1 |
