4M85
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8DAE
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5EP5
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8TUU
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8TUV
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8TUT
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8TUR
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8TUQ
| STL Polyomavirus LTA NLS bound to importin alpha 2 | 分子名称: | Importin subunit alpha-1, Large T antigen | 著者 | Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. | 登録日 | 2023-08-17 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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8TUS
| WU Polyomavirus LTA NLS bound to importin alpha 2 | 分子名称: | Importin subunit alpha-1, Large T antigen | 著者 | Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. | 登録日 | 2023-08-17 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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5EGJ
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5EGL
| The structural and biochemical characterization of acyl-coa hydrolase from Staphylococcus aureus in complex with Butyryl Coenzyme A, Coenzyme A, and Coenzyme A disulfide | 分子名称: | Acyl CoA Hydrolase, Butyryl Coenzyme A, COENZYME A, ... | 著者 | Khandokar, Y.B, Srivastava, P.S, Forwood, J.K. | 登録日 | 2015-10-27 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structural and biochemical characterization of acyl-coa hydrolase from Staphylococcus aureus To Be Published
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5EGK
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5EO4
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8VPU
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4WEP
| Apo YehZ from Escerichia coli | 分子名称: | Putative osmoprotectant uptake system substrate-binding protein OsmF | 著者 | Kimber, M.S, Lang, S, Mendoza, K, Wood, J.M. | 登録日 | 2014-09-10 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter. Biochemistry, 54, 2015
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8P4I
| Cyanide dihydratase from Bacillus pumilus C1 | 分子名称: | Cyanide dihydratase | 著者 | Mulelu, A.E, Reitz, J, van Rooyen, J.M, Scheffer, M, Frangakis, A.S, Dlamini, L.S, Woodward, J.D, Benedik, M.J, Sewell, B.T. | 登録日 | 2023-05-22 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | 主引用文献 | The Role of Histidine Residues in the Oligomerization of Cyanide Dihydratase from Bacillus pumilus C1 To Be Published
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9ER3
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7UYV
| Crystal structure of JAK3 kinase domain in complex with compound 25 | 分子名称: | 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide, CHLORIDE ION, Tyrosine-protein kinase JAK3 | 著者 | Toms, A.V, Leit, S, Greenwood, J.R, Mondal, S, Carriero, S, Dahlgren, M, Harriman, G.C, Kennedy-Smith, J.J, Kapeller, R, Lawson, J.P, Romero, D.L, Shelley, M, Wester, R.T, Westlin, W, Mc Elwee, J.J, Miao, W, Edmondson, S.D, Massee, C.E. | 登録日 | 2022-05-07 | 公開日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg.Med.Chem.Lett., 73, 2022
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8C5I
| Cyanide dihydratase from Bacillus pumilus C1 variant - Q86R,H305K,H308K,H323K | 分子名称: | Cyanide dihydratase | 著者 | Mulelu, A.E, Reitz, J, van Rooyen, J, Scheffer, M, Frangakis, A.S, Dlamini, L.S, Woodward, J.D, Benedik, M.J, Sewell, B.T. | 登録日 | 2023-01-09 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | The Role of Histidine Residues in the Oligomerization of Cyanide Dihydratase from Bacillus pumilus C1 To Be Published
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8G4J
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6VFN
| Crystal structure of SpeG allosteric polyamine acetyltransferase from Bacillus thuringiensis in complex with spermine | 分子名称: | SPERMINE, Spermidine N1-acetyltransferase | 著者 | Tsimbalyuk, S, Shornikov, A, Le, V.T.B, Kuhn, M.L, Forwood, J.K. | 登録日 | 2020-01-05 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | SpeG polyamine acetyltransferase enzyme from Bacillus thuringiensis forms a dodecameric structure and exhibits high catalytic efficiency. J.Struct.Biol., 210, 2020
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7UYU
| Crystal structure of TYK2 kinase domain in complex with compound 30 | 分子名称: | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5H-pyrrolo[3,4-b]pyridin-5-one, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION | 著者 | Toms, A.V, Leit, S, Greenwood, J.R, Mondal, S, Carriero, S, Dahlgren, M, Harriman, G.C, Kennedy-Smith, J.J, Kapeller, R, Lawson, J.P, Romero, D.L, Shelley, M, Wester, R.T, Westlin, W, Mc Elwee, J.J, Miao, W, Edmondson, S.D, Massee, C.E. | 登録日 | 2022-05-07 | 公開日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg.Med.Chem.Lett., 73, 2022
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7UYR
| Crystal structure of TYK2 kinase domain in complex with compound 12 | 分子名称: | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5H-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-N-ethylacetamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Toms, A.V, Leit, S, Greenwood, J.R, Mondal, S, Carriero, S, Dahlgren, M, Harriman, G.C, Kennedy-Smith, J.J, Kapeller, R, Lawson, J.P, Romero, D.L, Shelley, M, Wester, R.T, Westlin, W, Mc Elwee, J.J, Miao, W, Edmondson, S.D, Massee, C.E. | 登録日 | 2022-05-07 | 公開日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg.Med.Chem.Lett., 73, 2022
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7UYW
| Crystal structure of JAK2 kinase domain in complex with compound 30 | 分子名称: | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5H-pyrrolo[3,4-b]pyridin-5-one, Tyrosine-protein kinase JAK2 | 著者 | Toms, A.V, Leit, S, Greenwood, J.R, Mondal, S, Carriero, S, Dahlgren, M, Harriman, G.C, Kennedy-Smith, J.J, Kapeller, R, Lawson, J.P, Romero, D.L, Shelley, M, Wester, R.T, Westlin, W, Mc Elwee, J.J, Miao, W, Edmondson, S.D, Massee, C.E. | 登録日 | 2022-05-07 | 公開日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg.Med.Chem.Lett., 73, 2022
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7UYT
| Crystal structure of TYK2 kinase domain in complex with compound 25 | 分子名称: | 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Toms, A.V, Leit, S, Greenwood, J.R, Mondal, S, Carriero, S, Dahlgren, M, Harriman, G.C, Kennedy-Smith, J.J, Kapeller, R, Lawson, J.P, Romero, D.L, Shelley, M, Wester, R.T, Westlin, W, Mc Elwee, J.J, Miao, W, Edmondson, S.D, Massee, C.E. | 登録日 | 2022-05-07 | 公開日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg.Med.Chem.Lett., 73, 2022
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