7UYW

Crystal structure of JAK2 kinase domain in complex with compound 30

Summary for 7UYW

Entry DOI	10.2210/pdb7uyw/pdb
Descriptor	Tyrosine-protein kinase JAK2, 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5H-pyrrolo[3,4-b]pyridin-5-one (3 entities in total)
Functional Keywords	non-receptor tyrosine-protein kinase jak2, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34798.57
Authors	Toms, A.V.,Leit, S.,Greenwood, J.R.,Mondal, S.,Carriero, S.,Dahlgren, M.,Harriman, G.C.,Kennedy-Smith, J.J.,Kapeller, R.,Lawson, J.P.,Romero, D.L.,Shelley, M.,Wester, R.T.,Westlin, W.,Mc Elwee, J.J.,Miao, W.,Edmondson, S.D.,Massee, C.E. (deposition date: 2022-05-07, release date: 2022-08-24)
Primary citation	Leit, S.,Greenwood, J.R.,Mondal, S.,Carriero, S.,Dahlgren, M.,Harriman, G.C.,Kennedy-Smith, J.J.,Kapeller, R.,Lawson, J.P.,Romero, D.L.,Toms, A.V.,Shelley, M.,Wester, R.T.,Westlin, W.,McElwee, J.J.,Miao, W.,Edmondson, S.D.,Masse, C.E. Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg.Med.Chem.Lett., 73:128891-128891, 2022 Cited by PubMed: 35842205 DOI: 10.1016/j.bmcl.2022.128891 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.51 Å)

Structure validation