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PDB: 18 件
8K4N
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Structure of GPR34-Gi complex
分子名称: (2R)-2-azanyl-3-[oxidanyl-[(2R)-2-oxidanyl-3-tetradec-9-enoyloxy-propoxy]phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, He, G.D, Du, Y.
登録日2023-07-20
公開日2023-10-25
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Cryo-EM structure of GPR34-Gi complex
To Be Published
8ZRK
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Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263
分子名称: 5-[4-[[6-(4-methylsulfonylphenyl)pyridin-3-yl]oxymethyl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wong, T.S, Xiong, T.T, Zeng, Z.C, Gan, S.Y, Qiu, C, Du, Y.
登録日2024-06-04
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Cryo-EM structure of GPR119-Gs complex
To be published
8ZR5
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Cryo-EM Structure of GPR119-Gs-Firuglipel complex
分子名称: 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, Qiu, C, Du, Y.
登録日2024-06-04
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Cryo-EM structure of GPR119-Gs complex
To Be Published
1PWQ
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Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor
分子名称: Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.52 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWW
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Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
分子名称: LF20, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWV
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Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.
分子名称: LF20, Lethal factor
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWU
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Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.
分子名称: 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-02-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWP
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Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155
分子名称: Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION
著者Wong, T.Y, Schwarzenbacher, R, Liddington, R.C.
登録日2003-07-02
公開日2004-01-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
8HMV
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Structure of GPR21-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Wong, T.S, Gao, W.
登録日2022-12-05
公開日2023-03-01
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Cryo-EM structure of orphan G protein-coupled receptor GPR21.
MedComm (2020), 4, 2023
1ZXV
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X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.
分子名称: (E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID, ZINC ION, lethal factor
著者Wong, T.Y, Liddington, R.C.
登録日2005-06-08
公開日2005-07-05
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Efficient synthetic inhibitors of anthrax lethal factor.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1PG7
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Murine 6A6 Fab in complex with humanized anti-Tissue Factor D3H44 Fab
分子名称: humanized antibody D3H44, murine antibody 6A6 Fab fragment
著者Eigenbrot, C, Meng, Y.G, Krishnamurthy, R, Lipari, M.T, Presta, L, Devaux, B, Wong, T, Moran, P, Bullens, S, Kirchhofer, D.
登録日2003-05-27
公開日2003-08-26
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.
J.Mol.Biol., 331, 2003
2X7Y
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P450 BM3 F87A in complex with DMSO
分子名称: BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Kuper, J, Wong, T.S, Roccatano, D, Wilmanns, M, Schwaneberg, U.
登録日2010-03-04
公開日2011-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Role of Active-Site Phe87 in Modulating the Organic Co-Solvent Tolerance of Cytochrome P450 Bm3 Monooxygenase.
Acta Crystallogr.,Sect.F, 68, 2012
2X80
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P450 BM3 F87A in complex with DMSO
分子名称: BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Kuper, J, Wong, T.S, Roccatano, D, Wilmanns, M, Schwaneberg, U.
登録日2010-03-05
公開日2011-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Role of Active-Site Phe87 in Modulating the Organic Co-Solvent Tolerance of Cytochrome P450 Bm3 Monooxygenase.
Acta Crystallogr.,Sect.F, 68, 2012
1K6L
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Photosynethetic Reaction Center from Rhodobacter sphaeroides
分子名称: BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ...
著者Pokkuluri, P.R, Laible, P.D, Deng, Y.-L, Wong, T.N, Hanson, D.K, Schiffer, M.
登録日2001-10-16
公開日2002-08-07
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
Biochemistry, 41, 2002
1K6N
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E(L212)A,D(L213)A Double Mutant Structure of Photosynthetic Reaction Center from Rhodobacter Sphaeroides
分子名称: BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ...
著者Pokkuluri, P.R, Laible, P.D, Deng, Y.-L, Wong, T.N, Hanson, D.K, Schiffer, M.
登録日2001-10-16
公開日2002-08-07
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The structure of a mutant photosynthetic reaction center shows unexpected changes in main chain orientations and quinone position.
Biochemistry, 41, 2002
1J7N
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Anthrax Toxin Lethal factor
分子名称: Lethal Factor precursor, SULFATE ION, ZINC ION
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-05-17
公開日2001-11-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1JKY
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Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2
分子名称: Lethal Factor, mitogen-activated protein kinase kinase 2
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-07-13
公開日2001-11-07
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
4LMQ
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Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
分子名称: Stromal cell-derived factor 1, hu30D8 Fab heavy chain, hu30D8 Fab light chain
著者Zhong, Z, Wang, J, Li, B, Xiang, H, Ultsch, M, Coons, M, Wong, T, Chiang, N.Y, Clark, S, Clark, R, Quintana, L, Gribling, P, Suto, E, Barck, K, Corpuz, R, Yao, J, Takkar, R, Lee, W.P, Damico-Beyer, L.A, Carano, R.D, Adams, C, Kelley, R.F, Wang, W, Ferrara, N.
登録日2013-07-10
公開日2013-08-14
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.773 Å)
主引用文献Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12.
Clin.Cancer Res., 19, 2013

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