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PDB: 80 件
8FTK
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BU of 8ftk by Molmil
Chaetomium thermophilum SETX (Full-length)
分子名称: 5'-3' RNA helicase-like protein
著者Williams, R.S, Appel, C.D.
登録日2023-01-12
公開日2023-10-25
最終更新日2023-11-01
実験手法ELECTRON MICROSCOPY (4.56 Å)
主引用文献Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.
Mol.Cell, 83, 2023
8FTM
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BU of 8ftm by Molmil
Setx-ssRNA-ADP-SO4 complex
分子名称: 5'-3' RNA helicase-like protein, ADENOSINE-5'-DIPHOSPHATE, RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3'), ...
著者Williams, R.S, Appel, C.D.
登録日2023-01-12
公開日2023-10-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.
Mol.Cell, 83, 2023
8FTH
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BU of 8fth by Molmil
Chaetomium thermophilum SETX - NPPC internal deletion
分子名称: 5'-3' RNA helicase-like protein, ADENOSINE-5'-DIPHOSPHATE
著者Williams, R.S, Appel, C.D.
登録日2023-01-12
公開日2023-10-25
最終更新日2023-11-01
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.
Mol.Cell, 83, 2023
3L41
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BU of 3l41 by Molmil
Crystal Structure of S. pombe Brc1 BRCT5-BRCT6 domains in complex with phosphorylated H2A
分子名称: BRCT-containing protein 1, phosphorylated H2A tail
著者Williams, R.S, Williams, J.S, Guenther, G, Tainer, J.A.
登録日2009-12-18
公開日2010-02-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献gammaH2A binds Brc1 to maintain genome integrity during S-phase.
Embo J., 29, 2010
3L40
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BU of 3l40 by Molmil
Crystal Structure of S. pombe Brc1 BRCT5-BRCT6 domains
分子名称: BRCT-containing protein 1
著者Williams, R.S, Williams, J.S, Guenther, G, Tainer, J.A.
登録日2009-12-18
公開日2010-02-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献gammaH2A binds Brc1 to maintain genome integrity during S-phase.
Embo J., 29, 2010
5KIV
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BU of 5kiv by Molmil
Crystal structure of SauMacro (SAV0325)
分子名称: 1,2-ETHANEDIOL, ETHANOL, Protein-ADP-ribose hydrolase, ...
著者Williams, R.S, Appel, C.D, Feld, G.K, Wallace, B.D.
登録日2016-06-17
公開日2016-07-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus.
Protein Sci., 25, 2016
3DSC
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BU of 3dsc by Molmil
Crystal structure of P. furiosus Mre11 DNA synaptic complex
分子名称: DNA (5'-D(P*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DAP*DC)-3'), DNA double-strand break repair protein mre11
著者Williams, R.S, Moncalian, G, Shin, D.S, Tainer, J.A.
登録日2008-07-11
公開日2008-10-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Cell(Cambridge,Mass.), 135, 2008
3DSD
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BU of 3dsd by Molmil
Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese
分子名称: DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DGP*DAP*DTP*DA)-3'), DNA double-strand break repair protein mre11, MANGANESE (II) ION
著者Williams, R.S, Moiani, D, Tainer, J.A.
登録日2008-07-11
公開日2008-10-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Cell(Cambridge,Mass.), 135, 2008
3HUE
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BU of 3hue by Molmil
Structure of the S. pombe Nbs1 FHA-BRCT1-BRCT2 domains
分子名称: DNA repair and telomere maintenance protein nbs1
著者Williams, R.S, Guenther, G, Tainer, J.A.
登録日2009-06-13
公開日2009-10-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Cell(Cambridge,Mass.), 139, 2009
3HUF
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BU of 3huf by Molmil
Structure of the S. pombe Nbs1-Ctp1 complex
分子名称: DNA repair and telomere maintenance protein nbs1, Double-strand break repair protein ctp1, THIOCYANATE ION
著者Williams, R.S, Guenther, G, Tainer, J.A.
登録日2009-06-13
公開日2009-10-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Cell(Cambridge,Mass.), 139, 2009
1JNX
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BU of 1jnx by Molmil
Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
分子名称: BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, NICKEL (II) ION
著者Williams, R.S, Green, R, Glover, J.N.M.
登録日2001-07-26
公開日2001-09-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Nat.Struct.Biol., 8, 2001
1N5O
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BU of 1n5o by Molmil
Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
著者Williams, R.S, Glover, J.N.M.
登録日2002-11-06
公開日2002-12-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
J.Biol.Chem., 278, 2003
7UOA
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BU of 7uoa by Molmil
MAGEA4-MTP1 linear peptide complex
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTP-1, ...
著者Williams, R.S, Tumbale, P.S.
登録日2022-04-12
公開日2022-09-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.
J.Med.Chem., 65, 2022
1T2V
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BU of 1t2v by Molmil
Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide
分子名称: BRCTide-7PS, Breast cancer type 1 susceptibility protein
著者Williams, R.S, Lee, M.S, Hau, D.D, Glover, J.N.M.
登録日2004-04-22
公開日2004-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
1T2U
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BU of 1t2u by Molmil
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F
分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
著者Williams, R.S, Lee, M.S, Duong, D.D, Glover, J.N.M.
登録日2004-04-22
公開日2004-05-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis of Phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
5INK
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BU of 5ink by Molmil
Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DNA (5'-D(P*(3DR)P*CP*GP*AP*AP*TP*TP*CP*G)-3'), ...
著者Schellenberg, M.J, Williams, R.S.
登録日2016-03-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INM
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BU of 5inm by Molmil
Mouse Tdp2 protein, apo state with variable DNA-binding grasp conformations
分子名称: GLYCEROL, MAGNESIUM ION, SULFATE ION, ...
著者Schellenberg, M.J, Williams, R.S.
登録日2016-03-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
3SZQ
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BU of 3szq by Molmil
Structure of an S. pombe APTX/DNA/AMP/Zn complex
分子名称: 5'-D(*CP*CP*CP*TP*G)-3', 5'-D(*TP*AP*TP*CP*GP*GP*AP*AP*TP*CP*AP*GP*GP*G)-3', ADENOSINE MONOPHOSPHATE, ...
著者Tumbale, P, Krahn, J, Williams, R.S.
登録日2011-07-19
公開日2011-10-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.353 Å)
主引用文献Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.
Nat.Struct.Mol.Biol., 18, 2011
1YJ5
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Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme
分子名称: 5' polynucleotide kinase-3' phosphatase FHA domain, 5' polynucleotide kinase-3' phosphatase catalytic domain, SULFATE ION
著者Bernstein, N.K, Williams, R.S, Rakovszky, M.L, Cui, D, Green, R, Karimi-Busheri, F, Mani, R.S, Galicia, S, Koch, C.A, Cass, C.E, Durocher, D, Weinfeld, M, Glover, J.N.M.
登録日2005-01-13
公開日2005-03-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol.Cell, 17, 2005
1YJM
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Crystal structure of the FHA domain of mouse polynucleotide kinase in complex with an XRCC4-derived phosphopeptide.
分子名称: 12-mer peptide from DNA-repair protein XRCC4, Polynucleotide 5'-hydroxyl-kinase
著者Bernstein, N.K, Williams, R.S, Rakovszky, M.L, Cui, D, Green, R, Karimi-Busheri, F, Mani, R.S, Galicia, S, Koch, C.A, Cass, C.E, Durocher, D, Weinfeld, M, Glover, J.N.M.
登録日2005-01-14
公開日2005-03-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol.Cell, 17, 2005
7N3Z
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BU of 7n3z by Molmil
Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA-(apurinic or apyrimidinic site) endonuclease 2, ...
著者Wojtaszek, J.L, Wallace, B.D, Williams, R.S.
登録日2021-06-02
公開日2022-09-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Cell Rep, 41, 2022
7N3Y
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Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain E59Q/D222N Mutant in Complex with DNA
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CITRIC ACID, ...
著者Wojtaszek, J.L, Krahn, J, Wallace, B.D, Williams, R.S.
登録日2021-06-02
公開日2022-09-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Cell Rep, 41, 2022
4NCI
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BU of 4nci by Molmil
Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation
分子名称: DNA double-strand break repair Rad50 ATPase
著者Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S.
登録日2013-10-24
公開日2014-03-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Embo J., 33, 2014
4NCJ
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Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation with ADP Beryllium Flouride
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA double-strand break repair Rad50 ATPase, ...
著者Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S.
登録日2013-10-24
公開日2014-03-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Embo J., 33, 2014
4NCK
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Crystal Structure of Pyrococcus furiosis Rad50 R797G mutation
分子名称: CHLORIDE ION, DNA double-strand break repair Rad50 ATPase, MAGNESIUM ION, ...
著者Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S.
登録日2013-10-24
公開日2014-03-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Embo J., 33, 2014

 

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