3BJ4
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![BU of 3bj4 by Molmil](/molmil-images/mine/3bj4) | |
8B9X
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![BU of 8b9x by Molmil](/molmil-images/mine/8b9x) | Chimeric protein of human UFM1 E3 ligase, UFL1, and DDRGK1 | Descriptor: | CHLORIDE ION, DDRGK domain-containing protein 1,E3 UFM1-protein ligase 1 | Authors: | Wiener, R, Isupov, M, banerjee, S. | Deposit date: | 2022-10-10 | Release date: | 2023-10-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.066 Å) | Cite: | Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation. Embo Rep., 24, 2023
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4LDT
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![BU of 4ldt by Molmil](/molmil-images/mine/4ldt) | The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Ubiquitin, ... | Authors: | Wiener, R, DiBello, A.T, Lombardi, P.M, Guzzo, C.M, Zhang, X, Matunis, M.J, Wolberger, C. | Deposit date: | 2013-06-25 | Release date: | 2013-08-14 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nat.Struct.Mol.Biol., 20, 2013
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4DHI
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![BU of 4dhi by Molmil](/molmil-images/mine/4dhi) | Structure of C. elegans OTUB1 bound to human UBC13 | Descriptor: | Ubiquitin thioesterase otubain-like, Ubiquitin-conjugating enzyme E2 N | Authors: | Wiener, R, Zhang, X, Wang, T, Wolberger, C. | Deposit date: | 2012-01-27 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature, 483, 2012
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4DHJ
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![BU of 4dhj by Molmil](/molmil-images/mine/4dhj) | The structure of a ceOTUB1 ubiquitin aldehyde UBC13~Ub complex | Descriptor: | Ubiquitin, Ubiquitin aldehyde, Ubiquitin thioesterase otubain-like, ... | Authors: | Wiener, R, Zhang, X, Wang, T, Wolberger, C. | Deposit date: | 2012-01-27 | Release date: | 2012-02-22 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature, 483, 2012
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4DHZ
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![BU of 4dhz by Molmil](/molmil-images/mine/4dhz) | The structure of h/ceOTUB1-ubiquitin aldehyde-UBC13~Ub | Descriptor: | Ubiquitin, Ubiquitin aldehyde, Ubiquitin thioesterase otubain-like, ... | Authors: | Wiener, R, Zhang, X, Wang, T, Wolberger, C. | Deposit date: | 2012-01-30 | Release date: | 2012-02-22 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature, 483, 2012
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5L95
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![BU of 5l95 by Molmil](/molmil-images/mine/5l95) | Crystal structure of human UBA5 in complex with UFM1 and AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-fold modifier 1, Ubiquitin-like modifier-activating enzyme 5, ... | Authors: | Oweis, W, Padala, P, Wiener, R. | Deposit date: | 2016-06-09 | Release date: | 2016-09-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex. Cell Rep, 16, 2016
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5O44
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![BU of 5o44 by Molmil](/molmil-images/mine/5o44) | Crystal structure of unbranched mixed tri-Ubiquitin chain containing K48 and K63 linkages. | Descriptor: | MAGNESIUM ION, Polyubiquitin-B, SULFATE ION, ... | Authors: | Padala, P, Isupov, M.N, Wiener, R. | Deposit date: | 2017-05-26 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | The Crystal Structure and Conformations of an Unbranched Mixed Tri-Ubiquitin Chain Containing K48 and K63 Linkages. J. Mol. Biol., 429, 2017
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4FH1
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![BU of 4fh1 by Molmil](/molmil-images/mine/4fh1) | S. cerevisiae Ubc13-N79A | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Ubiquitin-conjugating enzyme E2 13 | Authors: | Berndsen, C.E, Wolberger, C, Wiener, R. | Deposit date: | 2012-06-05 | Release date: | 2013-01-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | A conserved asparagine has a structural role in ubiquitin-conjugating enzymes. Nat.Chem.Biol., 9, 2013
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6H77
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![BU of 6h77 by Molmil](/molmil-images/mine/6h77) | E1 enzyme for ubiquitin like protein activation in complex with UBL | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Soudah, N, Padala, P, Hassouna, F, Mashahreh, B, Lebedev, A.A, Isupov, M.N, Cohen-Kfir, E, Wiener, R. | Deposit date: | 2018-07-30 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation. J.Mol.Biol., 431, 2019
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6H78
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![BU of 6h78 by Molmil](/molmil-images/mine/6h78) | E1 enzyme for ubiquitin like protein activation. | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Soudah, N, Padala, P, Hassouna, F, Mashahreh, B, Lebedev, A.A, Isupov, M.N, Cohen-Kfir, E, Wiener, R. | Deposit date: | 2018-07-30 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation. J.Mol.Biol., 431, 2019
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7NVJ
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![BU of 7nvj by Molmil](/molmil-images/mine/7nvj) | Crystal structure of UFC1 Y110A & F121A | Descriptor: | GLYCEROL, Ubiquitin-fold modifier-conjugating enzyme 1 | Authors: | Manoj Kumar, P, Padala, P, Isupov, M.N, Wiener, R. | Deposit date: | 2021-03-15 | Release date: | 2021-09-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for UFM1 transfer from UBA5 to UFC1. Nat Commun, 12, 2021
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7NVK
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![BU of 7nvk by Molmil](/molmil-images/mine/7nvk) | Crystal structure of UBA5 fragment fused to the N-terminus of UFC1 | Descriptor: | Ubiquitin-like modifier-activating enzyme 5,Ubiquitin-fold modifier-conjugating enzyme 1 | Authors: | Manoj Kumar, P, Padala, P, Isupov, M.N, Wiener, R. | Deposit date: | 2021-03-15 | Release date: | 2021-09-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.651 Å) | Cite: | Structural basis for UFM1 transfer from UBA5 to UFC1. Nat Commun, 12, 2021
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7NW1
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![BU of 7nw1 by Molmil](/molmil-images/mine/7nw1) | Crystal structure of UFC1 in complex with UBA5 | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Manoj Kumar, P, Padala, P, Isupov, M.N, Wiener, R. | Deposit date: | 2021-03-16 | Release date: | 2021-09-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for UFM1 transfer from UBA5 to UFC1. Nat Commun, 12, 2021
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7ZUG
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![BU of 7zug by Molmil](/molmil-images/mine/7zug) | Heterogeneous nuclear ribonucleoprotein H1, qRRM2 domain | Descriptor: | CHLORIDE ION, Heterogeneous nuclear ribonucleoprotein H, N-terminally processed, ... | Authors: | Winter, N, Kumar, M, Isupov, M.N, Wiener, R. | Deposit date: | 2022-05-12 | Release date: | 2023-05-24 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.075 Å) | Cite: | Heterogeneous nuclear ribonucleoprotein H1, qRRM2 domain To Be Published
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8AXG
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![BU of 8axg by Molmil](/molmil-images/mine/8axg) | Crystal structure of Fusobacterium nucleatum fusolisin protease | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Fusolisin, ... | Authors: | Isupov, M.N, Wiener, R, Rouvinski, A, Fahoum, J, Kumar, M, Read, R.J. | Deposit date: | 2022-08-31 | Release date: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Crystal structure of Fusobacterium nucleatum fusolisin protease To Be Published
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8EDD
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![BU of 8edd by Molmil](/molmil-images/mine/8edd) | Staphylococcus aureus endonuclease IV Y33F mutant | Descriptor: | CHLORIDE ION, FE (III) ION, PHOSPHATE ION, ... | Authors: | Saper, M.A, Kirillov, S, Isupov, M.N, Wiener, R, Rouvinski, A. | Deposit date: | 2022-09-04 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Octahedrally coordinated iron in the catalytic site of endonuclease IV from Staphylococcus aureus To Be Published
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5IAA
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![BU of 5iaa by Molmil](/molmil-images/mine/5iaa) | Crystal structure of human UBA5 in complex with UFM1 | Descriptor: | Ubiquitin-fold modifier 1, Ubiquitin-like modifier-activating enzyme 5, ZINC ION | Authors: | Oweis, W, Padala, P, Wiener, R. | Deposit date: | 2016-02-21 | Release date: | 2016-09-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex. Cell Rep, 16, 2016
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5IA8
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5IA7
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8AXY
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![BU of 8axy by Molmil](/molmil-images/mine/8axy) | Staphylococcus aureus endonuclease IV orthorhombic crystal form | Descriptor: | FE (III) ION, Probable endonuclease 4, SULFATE ION, ... | Authors: | Rouvinski, A, Kirillov, S, Saper, M.A, Wiener, R, Isupov, M.N. | Deposit date: | 2022-09-01 | Release date: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Octahedrally coordinated iron in the catalytic site of endonuclease IV from Staphylococcus aureus To Be Published
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