6H78

E1 enzyme for ubiquitin like protein activation.

Summary for 6H78

• Entry DOI: 10.2210/pdb6h78/pdb
• Descriptor: Ubiquitin-like modifier-activating enzyme 5, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: ubiquitin like protein activating enzyme, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 545129.19

Authors

Soudah, N.,Padala, P.,Hassouna, F.,Mashahreh, B.,Lebedev, A.A.,Isupov, M.N.,Cohen-Kfir, E.,Wiener, R. (deposition date: 2018-07-30, release date: 2018-10-31, Last modification date: 2024-01-17)

• Primary citation: Soudah, N.,Padala, P.,Hassouna, F.,Kumar, M.,Mashahreh, B.,Lebedev, A.A.,Isupov, M.N.,Cohen-Kfir, E.,Wiener, R.; An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation.; J.Mol.Biol., 431:463-478, 2019; PubMed: 30412706; DOI: 10.1016/j.jmb.2018.10.007

Experimental method

X-RAY DIFFRACTION (2.7 Å)