6H78
E1 enzyme for ubiquitin like protein activation.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| B | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| C | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| D | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| E | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| F | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| G | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| H | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| I | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| J | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| K | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| L | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| M | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| N | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| O | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| P | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue ATP A 401 |
| Chain | Residue |
| A | GLY80 |
| A | ASN150 |
| A | ILE151 |
| A | THR152 |
| A | CYS181 |
| A | ASP183 |
| A | ASN184 |
| A | ALA187 |
| A | MG402 |
| A | MG404 |
| A | HOH501 |
| A | GLY82 |
| A | HOH502 |
| A | HOH511 |
| A | HOH520 |
| A | HOH526 |
| A | HOH544 |
| A | HOH545 |
| B | ARG55 |
| A | GLY83 |
| A | ASP104 |
| A | TYR105 |
| A | ASP106 |
| A | ASN112 |
| A | ARG115 |
| A | LYS127 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP183 |
| A | ATP401 |
| A | HOH502 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 403 |
| Chain | Residue |
| A | CYS226 |
| A | CYS229 |
| A | CYS303 |
| A | CYS308 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | ASP106 |
| A | ATP401 |
| A | HOH501 |
| A | HOH503 |
| A | HOH526 |
| A | HOH567 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | ASN210 |
| A | ASP240 |
| A | GLU241 |
| A | LYS242 |
| A | THR243 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | PRO301 |
| A | ARG309 |
| A | GLN312 |
| A | GLU313 |
| A | LYS316 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | MET189 |
| A | ASN192 |
| A | THR193 |
| A | ASP305 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | binding site for residue ATP B 401 |
| Chain | Residue |
| A | ARG55 |
| B | GLY80 |
| B | GLY82 |
| B | GLY83 |
| B | ASP104 |
| B | TYR105 |
| B | ASP106 |
| B | ASN112 |
| B | ARG115 |
| B | LYS127 |
| B | TYR149 |
| B | ASN150 |
| B | ILE151 |
| B | THR152 |
| B | CYS181 |
| B | VAL182 |
| B | ASP183 |
| B | ASN184 |
| B | MG402 |
| B | MG404 |
| B | HOH519 |
| B | HOH524 |
| B | HOH537 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASP183 |
| B | ATP401 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 403 |
| Chain | Residue |
| B | CYS226 |
| B | CYS229 |
| B | CYS303 |
| B | CYS308 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 404 |
| Chain | Residue |
| A | HOH539 |
| B | ASP106 |
| B | ATP401 |
| B | HOH504 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| A | GLN119 |
| B | THR134 |
| E | GLY36 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| B | PHE272 |
| B | LEU273 |
| B | ASN275 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | THR152 |
| B | PHE157 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 408 |
| Chain | Residue |
| B | PHE281 |
| B | MET295 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 409 |
| Chain | Residue |
| B | HOH505 |
| site_id | AD8 |
| Number of Residues | 24 |
| Details | binding site for residue ATP C 401 |
| Chain | Residue |
| C | GLY83 |
| C | ASP104 |
| C | TYR105 |
| C | ASP106 |
| C | ASN112 |
| C | ARG115 |
| C | LYS127 |
| C | ASN150 |
| C | ILE151 |
| C | THR152 |
| C | CYS181 |
| C | VAL182 |
| C | ASP183 |
| C | ASN184 |
| C | ALA187 |
| C | MET258 |
| C | MG402 |
| C | MG404 |
| C | HOH511 |
| C | HOH517 |
| C | HOH523 |
| D | ARG55 |
| C | GLY80 |
| C | GLY82 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | ASP183 |
| C | ATP401 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 403 |
| Chain | Residue |
| C | CYS226 |
| C | CYS229 |
| C | CYS303 |
| C | CYS308 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 404 |
| Chain | Residue |
| C | ASP106 |
| C | LYS127 |
| C | ATP401 |
| C | HOH501 |
| C | HOH517 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 405 |
| Chain | Residue |
| C | SER213 |
| C | GLY214 |
| C | HIS215 |
| C | VAL235 |
| site_id | AE4 |
| Number of Residues | 23 |
| Details | binding site for residue ATP D 401 |
| Chain | Residue |
| C | ARG55 |
| D | GLY80 |
| D | GLY82 |
| D | GLY83 |
| D | ASP104 |
| D | TYR105 |
| D | ASP106 |
| D | ASN112 |
| D | ARG115 |
| D | LYS127 |
| D | TYR149 |
| D | ASN150 |
| D | ILE151 |
| D | ASP183 |
| D | ASN184 |
| D | MG402 |
| D | MG404 |
| D | EDO405 |
| D | HOH502 |
| D | HOH503 |
| D | HOH509 |
| D | HOH510 |
| D | HOH515 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 402 |
| Chain | Residue |
| D | ASP183 |
| D | ATP401 |
| D | HOH503 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 403 |
| Chain | Residue |
| D | CYS226 |
| D | CYS229 |
| D | CYS303 |
| D | CYS308 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 404 |
| Chain | Residue |
| D | ASP106 |
| D | ATP401 |
| D | HOH511 |
| D | HOH537 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 405 |
| Chain | Residue |
| D | GLY83 |
| D | VAL84 |
| D | CYS181 |
| D | ASP183 |
| D | ATP401 |
| D | HOH506 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 406 |
| Chain | Residue |
| D | GLN129 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 407 |
| Chain | Residue |
| D | HIS121 |
| D | HIS133 |
| D | THR134 |
| site_id | AF2 |
| Number of Residues | 22 |
| Details | binding site for residue ATP E 401 |
| Chain | Residue |
| E | GLY80 |
| E | GLY82 |
| E | GLY83 |
| E | ASP104 |
| E | TYR105 |
| E | ASP106 |
| E | ASN112 |
| E | ARG115 |
| E | LYS127 |
| E | ASN150 |
| E | ILE151 |
| E | THR152 |
| E | CYS181 |
| E | ASP183 |
| E | ASN184 |
| E | MG402 |
| E | MG404 |
| E | HOH501 |
| E | HOH502 |
| E | HOH516 |
| E | HOH536 |
| F | ARG55 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 402 |
| Chain | Residue |
| E | ASP183 |
| E | ATP401 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 403 |
| Chain | Residue |
| E | CYS226 |
| E | CYS229 |
| E | CYS303 |
| E | CYS308 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 404 |
| Chain | Residue |
| E | ASP106 |
| E | ATP401 |
| E | HOH501 |
| E | HOH540 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 405 |
| Chain | Residue |
| E | GLU223 |
| E | SER296 |
| E | MET297 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 406 |
| Chain | Residue |
| E | PRO301 |
| E | ARG309 |
| E | GLN312 |
| site_id | AF8 |
| Number of Residues | 27 |
| Details | binding site for residue ATP F 401 |
| Chain | Residue |
| E | ARG55 |
| F | GLY80 |
| F | GLY82 |
| F | GLY83 |
| F | ASP104 |
| F | TYR105 |
| F | ASP106 |
| F | ASN112 |
| F | ARG115 |
| F | LYS127 |
| F | TYR149 |
| F | ASN150 |
| F | ILE151 |
| F | THR152 |
| F | ASP183 |
| F | ASN184 |
| F | ALA187 |
| F | MET258 |
| F | MG402 |
| F | MG404 |
| F | HOH502 |
| F | HOH507 |
| F | HOH520 |
| F | HOH524 |
| F | HOH531 |
| F | HOH534 |
| F | HOH536 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 402 |
| Chain | Residue |
| F | ASP183 |
| F | ATP401 |
| F | HOH502 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 403 |
| Chain | Residue |
| F | CYS226 |
| F | CYS229 |
| F | CYS303 |
| F | CYS308 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 404 |
| Chain | Residue |
| F | ASP106 |
| F | ATP401 |
| F | HOH507 |
| F | HOH536 |
| site_id | AG3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 405 |
| Chain | Residue |
| A | GLY36 |
| F | ASN137 |
| F | HOH526 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO F 406 |
| Chain | Residue |
| F | GLY284 |
| F | TYR285 |
| F | ASN286 |
| F | PRO293 |
| site_id | AG5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO F 407 |
| Chain | Residue |
| F | GLU223 |
| F | MET297 |
| site_id | AG6 |
| Number of Residues | 23 |
| Details | binding site for residue ATP G 401 |
| Chain | Residue |
| G | GLY80 |
| G | GLY82 |
| G | GLY83 |
| G | ASP104 |
| G | TYR105 |
| G | ASP106 |
| G | ASN112 |
| G | ARG115 |
| G | LYS127 |
| G | TYR149 |
| G | ASN150 |
| G | ILE151 |
| G | THR152 |
| G | CYS181 |
| G | VAL182 |
| G | ASP183 |
| G | ASN184 |
| G | MG402 |
| G | MG404 |
| G | HOH503 |
| G | HOH514 |
| G | HOH520 |
| H | ARG55 |
| site_id | AG7 |
| Number of Residues | 3 |
| Details | binding site for residue MG G 402 |
| Chain | Residue |
| G | ASP183 |
| G | ATP401 |
| G | HOH503 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 403 |
| Chain | Residue |
| G | CYS226 |
| G | CYS229 |
| G | CYS303 |
| G | CYS308 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue MG G 404 |
| Chain | Residue |
| G | ASP106 |
| G | LYS127 |
| G | ATP401 |
| G | HOH550 |
| site_id | AH1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO G 405 |
| Chain | Residue |
| G | ASN196 |
| G | GLU197 |
| G | ASN307 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO G 406 |
| Chain | Residue |
| G | VAL175 |
| G | ASP176 |
| G | GLY199 |
| G | GLN200 |
| G | EDO407 |
| G | HOH502 |
| site_id | AH3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO G 407 |
| Chain | Residue |
| G | LEU198 |
| G | GLY199 |
| G | EDO406 |
| site_id | AH4 |
| Number of Residues | 27 |
| Details | binding site for residue ATP H 401 |
| Chain | Residue |
| G | ARG55 |
| H | GLY80 |
| H | GLY82 |
| H | GLY83 |
| H | ASP104 |
| H | TYR105 |
| H | ASP106 |
| H | ASN112 |
| H | ARG115 |
| H | LYS127 |
| H | ASN150 |
| H | ILE151 |
| H | THR152 |
| H | CYS181 |
| H | VAL182 |
| H | ASP183 |
| H | ASN184 |
| H | ALA187 |
| H | MG402 |
| H | MG404 |
| H | HOH510 |
| H | HOH511 |
| H | HOH520 |
| H | HOH521 |
| H | HOH525 |
| H | HOH535 |
| H | HOH537 |
| site_id | AH5 |
| Number of Residues | 2 |
| Details | binding site for residue MG H 402 |
| Chain | Residue |
| H | ASP183 |
| H | ATP401 |
| site_id | AH6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 403 |
| Chain | Residue |
| H | CYS226 |
| H | CYS229 |
| H | CYS303 |
| H | CYS308 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue MG H 404 |
| Chain | Residue |
| H | ASP106 |
| H | ATP401 |
| H | HOH511 |
| H | HOH521 |
| H | HOH525 |
| site_id | AH8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO H 405 |
| Chain | Residue |
| G | GLU90 |
| G | PHE117 |
| H | PHE117 |
| H | GLN119 |
| site_id | AH9 |
| Number of Residues | 26 |
| Details | binding site for residue ATP I 400 |
| Chain | Residue |
| I | GLY80 |
| I | GLY82 |
| I | GLY83 |
| I | ASP104 |
| I | TYR105 |
| I | ASP106 |
| I | ASN112 |
| I | ARG115 |
| I | LYS127 |
| I | TYR149 |
| I | ASN150 |
| I | ILE151 |
| I | THR152 |
| I | CYS181 |
| I | ASP183 |
| I | ASN184 |
| I | MG401 |
| I | MG403 |
| I | HOH505 |
| I | HOH520 |
| I | HOH521 |
| I | HOH528 |
| I | HOH530 |
| I | HOH540 |
| I | HOH541 |
| J | ARG55 |
| site_id | AI1 |
| Number of Residues | 3 |
| Details | binding site for residue MG I 401 |
| Chain | Residue |
| I | ASP183 |
| I | ATP400 |
| I | HOH546 |
| site_id | AI2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN I 402 |
| Chain | Residue |
| I | CYS226 |
| I | CYS229 |
| I | CYS303 |
| I | CYS308 |
| site_id | AI3 |
| Number of Residues | 6 |
| Details | binding site for residue MG I 403 |
| Chain | Residue |
| I | ASP106 |
| I | ATP400 |
| I | HOH501 |
| I | HOH504 |
| I | HOH505 |
| I | HOH540 |
| site_id | AI4 |
| Number of Residues | 23 |
| Details | binding site for residue ATP J 401 |
| Chain | Residue |
| I | ARG55 |
| J | GLY80 |
| J | GLY82 |
| J | GLY83 |
| J | ASP104 |
| J | TYR105 |
| J | ASP106 |
| J | ARG115 |
| J | LYS127 |
| J | ASN150 |
| J | ILE151 |
| J | CYS181 |
| J | VAL182 |
| J | ASP183 |
| J | ASN184 |
| J | MG402 |
| J | MG404 |
| J | HOH503 |
| J | HOH505 |
| J | HOH516 |
| J | HOH529 |
| J | HOH531 |
| J | HOH540 |
| site_id | AI5 |
| Number of Residues | 3 |
| Details | binding site for residue MG J 402 |
| Chain | Residue |
| J | ASP183 |
| J | ATP401 |
| J | HOH529 |
| site_id | AI6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN J 403 |
| Chain | Residue |
| J | CYS226 |
| J | CYS229 |
| J | CYS303 |
| J | CYS308 |
| site_id | AI7 |
| Number of Residues | 6 |
| Details | binding site for residue MG J 404 |
| Chain | Residue |
| J | ASP106 |
| J | LYS127 |
| J | ATP401 |
| J | HOH505 |
| J | HOH506 |
| J | HOH531 |
| site_id | AI8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO J 405 |
| Chain | Residue |
| D | HIS121 |
| J | HIS121 |
| J | GLN122 |
| J | HIS133 |
| J | THR134 |
| J | HOH513 |
| J | HOH543 |
| site_id | AI9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO J 406 |
| Chain | Residue |
| I | GLU90 |
| I | PHE117 |
| I | GLN119 |
| J | GLU90 |
| J | PHE117 |
| J | GLN119 |
| site_id | AJ1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO J 407 |
| Chain | Residue |
| J | TYR105 |
| site_id | AJ2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO J 408 |
| Chain | Residue |
| J | PHE272 |
| J | ASN275 |
| site_id | AJ3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO J 409 |
| Chain | Residue |
| J | PRO301 |
| J | ARG309 |
| J | LYS316 |
| site_id | AJ4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO J 410 |
| Chain | Residue |
| J | VAL279 |
| J | SER280 |
| J | PHE281 |
| J | THR294 |
| J | MET295 |
| site_id | AJ5 |
| Number of Residues | 24 |
| Details | binding site for residue ATP K 401 |
| Chain | Residue |
| K | GLY80 |
| K | GLY82 |
| K | GLY83 |
| K | ASP104 |
| K | TYR105 |
| K | ASP106 |
| K | ASN112 |
| K | ARG115 |
| K | LYS127 |
| K | ASN150 |
| K | ILE151 |
| K | THR152 |
| K | CYS181 |
| K | VAL182 |
| K | ASP183 |
| K | ASN184 |
| K | ALA187 |
| K | MG402 |
| K | MG404 |
| K | HOH501 |
| K | HOH516 |
| K | HOH533 |
| K | HOH535 |
| L | ARG55 |
| site_id | AJ6 |
| Number of Residues | 3 |
| Details | binding site for residue MG K 402 |
| Chain | Residue |
| K | ASP183 |
| K | ATP401 |
| K | HOH501 |
| site_id | AJ7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN K 403 |
| Chain | Residue |
| K | CYS226 |
| K | CYS229 |
| K | CYS303 |
| K | CYS308 |
| site_id | AJ8 |
| Number of Residues | 6 |
| Details | binding site for residue MG K 404 |
| Chain | Residue |
| K | ASP106 |
| K | ATP401 |
| K | HOH508 |
| K | HOH509 |
| K | HOH540 |
| K | HOH544 |
| site_id | AJ9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO K 405 |
| Chain | Residue |
| K | PRO301 |
| K | GLU313 |
| K | LYS316 |
| site_id | AK1 |
| Number of Residues | 1 |
| Details | binding site for residue CL K 407 |
| Chain | Residue |
| K | ASN156 |
| site_id | AK2 |
| Number of Residues | 22 |
| Details | binding site for residue ATP L 401 |
| Chain | Residue |
| K | ARG55 |
| L | GLY80 |
| L | GLY82 |
| L | GLY83 |
| L | ASP104 |
| L | TYR105 |
| L | ASP106 |
| L | ASN112 |
| L | ARG115 |
| L | LYS127 |
| L | ASN150 |
| L | ILE151 |
| L | CYS181 |
| L | VAL182 |
| L | ASP183 |
| L | ASN184 |
| L | ALA187 |
| L | MG402 |
| L | MG404 |
| L | HOH501 |
| L | HOH502 |
| L | HOH539 |
| site_id | AK3 |
| Number of Residues | 3 |
| Details | binding site for residue MG L 402 |
| Chain | Residue |
| L | ASP183 |
| L | ATP401 |
| L | HOH501 |
| site_id | AK4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN L 403 |
| Chain | Residue |
| L | CYS226 |
| L | CYS229 |
| L | CYS303 |
| L | CYS308 |
| site_id | AK5 |
| Number of Residues | 5 |
| Details | binding site for residue MG L 404 |
| Chain | Residue |
| L | ASP106 |
| L | LYS127 |
| L | ATP401 |
| L | HOH520 |
| L | HOH537 |
| site_id | AK6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO L 405 |
| Chain | Residue |
| L | GLN129 |
| L | HOH509 |
| P | ARG136 |
| site_id | AK7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO L 406 |
| Chain | Residue |
| L | ASN196 |
| L | GLU197 |
| site_id | AK8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO L 407 |
| Chain | Residue |
| L | PRO174 |
| L | VAL175 |
| L | ASP176 |
| L | HOH505 |
| L | HOH538 |
| site_id | AK9 |
| Number of Residues | 21 |
| Details | binding site for residue ATP M 401 |
| Chain | Residue |
| M | GLY80 |
| M | GLY82 |
| M | GLY83 |
| M | ASP104 |
| M | TYR105 |
| M | ASP106 |
| M | ASN112 |
| M | ARG115 |
| M | LYS127 |
| M | ASN150 |
| M | ILE151 |
| M | CYS181 |
| M | VAL182 |
| M | ASP183 |
| M | ASN184 |
| M | MET258 |
| M | MG402 |
| M | MG404 |
| M | HOH501 |
| M | HOH526 |
| N | ARG55 |
| site_id | AL1 |
| Number of Residues | 3 |
| Details | binding site for residue MG M 402 |
| Chain | Residue |
| M | ASP183 |
| M | ATP401 |
| M | HOH501 |
| site_id | AL2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN M 403 |
| Chain | Residue |
| M | CYS226 |
| M | CYS229 |
| M | CYS303 |
| M | CYS308 |
| site_id | AL3 |
| Number of Residues | 4 |
| Details | binding site for residue MG M 404 |
| Chain | Residue |
| M | ASP106 |
| M | ATP401 |
| M | HOH533 |
| M | HOH537 |
| site_id | AL4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO M 405 |
| Chain | Residue |
| M | ASN148 |
| site_id | AL5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO M 406 |
| Chain | Residue |
| M | SER296 |
| M | MET297 |
| site_id | AL6 |
| Number of Residues | 25 |
| Details | binding site for residue ATP N 401 |
| Chain | Residue |
| M | ARG55 |
| N | GLY80 |
| N | GLY82 |
| N | GLY83 |
| N | ASP104 |
| N | TYR105 |
| N | ASP106 |
| N | ASN112 |
| N | ARG115 |
| N | LYS127 |
| N | ASN150 |
| N | ILE151 |
| N | THR152 |
| N | CYS181 |
| N | VAL182 |
| N | ASP183 |
| N | ASN184 |
| N | MG402 |
| N | MG404 |
| N | HOH506 |
| N | HOH511 |
| N | HOH516 |
| N | HOH517 |
| N | HOH519 |
| N | HOH524 |
| site_id | AL7 |
| Number of Residues | 2 |
| Details | binding site for residue MG N 402 |
| Chain | Residue |
| N | ASP183 |
| N | ATP401 |
| site_id | AL8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN N 403 |
| Chain | Residue |
| N | CYS226 |
| N | CYS229 |
| N | CYS303 |
| N | CYS308 |
| site_id | AL9 |
| Number of Residues | 6 |
| Details | binding site for residue MG N 404 |
| Chain | Residue |
| N | ASP106 |
| N | ATP401 |
| N | HOH511 |
| N | HOH517 |
| N | HOH523 |
| N | HOH526 |
| site_id | AM1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO N 405 |
| Chain | Residue |
| N | GLU155 |
| N | HIS159 |
| site_id | AM2 |
| Number of Residues | 26 |
| Details | binding site for residue ATP O 401 |
| Chain | Residue |
| O | GLY80 |
| O | GLY82 |
| O | GLY83 |
| O | ASP104 |
| O | TYR105 |
| O | ASP106 |
| O | ASN112 |
| O | ARG115 |
| O | LYS127 |
| O | TYR149 |
| O | ASN150 |
| O | ILE151 |
| O | THR152 |
| O | CYS181 |
| O | VAL182 |
| O | ASP183 |
| O | ASN184 |
| O | ALA187 |
| O | MG402 |
| O | MG404 |
| O | HOH517 |
| O | HOH520 |
| O | HOH524 |
| O | HOH526 |
| O | HOH528 |
| P | ARG55 |
| site_id | AM3 |
| Number of Residues | 2 |
| Details | binding site for residue MG O 402 |
| Chain | Residue |
| O | ASP183 |
| O | ATP401 |
| site_id | AM4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN O 403 |
| Chain | Residue |
| O | CYS226 |
| O | CYS229 |
| O | CYS303 |
| O | CYS308 |
| site_id | AM5 |
| Number of Residues | 6 |
| Details | binding site for residue MG O 404 |
| Chain | Residue |
| O | ASP106 |
| O | ATP401 |
| O | HOH519 |
| O | HOH520 |
| O | HOH524 |
| O | HOH526 |
| site_id | AM6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO O 405 |
| Chain | Residue |
| O | PHE117 |
| O | GLN119 |
| P | GLU90 |
| P | PHE117 |
| site_id | AM7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO O 406 |
| Chain | Residue |
| O | GLU223 |
| O | MET297 |
| O | LYS298 |
| site_id | AM8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO O 407 |
| Chain | Residue |
| O | GLU155 |
| O | ASN156 |
| site_id | AM9 |
| Number of Residues | 27 |
| Details | binding site for residue ATP P 401 |
| Chain | Residue |
| O | ARG55 |
| P | GLY80 |
| P | GLY82 |
| P | GLY83 |
| P | ASP104 |
| P | TYR105 |
| P | ASP106 |
| P | ASN112 |
| P | ARG115 |
| P | LYS127 |
| P | TYR149 |
| P | ASN150 |
| P | ILE151 |
| P | THR152 |
| P | CYS181 |
| P | VAL182 |
| P | ASP183 |
| P | ASN184 |
| P | ALA187 |
| P | MG402 |
| P | MG404 |
| P | EDO405 |
| P | HOH504 |
| P | HOH509 |
| P | HOH511 |
| P | HOH516 |
| P | HOH517 |
| site_id | AN1 |
| Number of Residues | 2 |
| Details | binding site for residue MG P 402 |
| Chain | Residue |
| P | ASP183 |
| P | ATP401 |
| site_id | AN2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN P 403 |
| Chain | Residue |
| P | CYS226 |
| P | CYS229 |
| P | CYS303 |
| P | CYS308 |
| site_id | AN3 |
| Number of Residues | 5 |
| Details | binding site for residue MG P 404 |
| Chain | Residue |
| P | ASP106 |
| P | LYS127 |
| P | ATP401 |
| P | HOH516 |
| P | HOH527 |
| site_id | AN4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO P 405 |
| Chain | Residue |
| P | ALA251 |
| P | ATP401 |
| site_id | AN5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO P 406 |
| Chain | Residue |
| P | SER213 |
| P | HIS215 |
| P | VAL235 |
| site_id | AN6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO P 407 |
| Chain | Residue |
| P | GLU223 |
| P | MET297 |
| site_id | AN7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO P 408 |
| Chain | Residue |
| B | PHE291 |
| P | ASN286 |
| P | GLN289 |
| P | PHE291 |
| P | HOH521 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 29 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VAIVGvGGVGsvtaemltrcgigkLLlFD |
| Chain | Residue | Details |
| A | VAL76-ASP104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:34588452 |
| Chain | Residue | Details |
| A | CYS250 | |
| J | CYS250 | |
| K | CYS250 | |
| L | CYS250 | |
| M | CYS250 | |
| N | CYS250 | |
| O | CYS250 | |
| P | CYS250 | |
| B | CYS250 | |
| C | CYS250 | |
| D | CYS250 | |
| E | CYS250 | |
| F | CYS250 | |
| G | CYS250 | |
| H | CYS250 | |
| I | CYS250 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 64 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H77, ECO:0007744|PDB:6H78 |
| Chain | Residue | Details |
| A | GLY83 | |
| C | LYS127 | |
| C | ASN150 | |
| C | ASN184 | |
| D | GLY83 | |
| D | LYS127 | |
| D | ASN150 | |
| D | ASN184 | |
| E | GLY83 | |
| E | LYS127 | |
| E | ASN150 | |
| A | LYS127 | |
| E | ASN184 | |
| F | GLY83 | |
| F | LYS127 | |
| F | ASN150 | |
| F | ASN184 | |
| G | GLY83 | |
| G | LYS127 | |
| G | ASN150 | |
| G | ASN184 | |
| H | GLY83 | |
| A | ASN150 | |
| H | LYS127 | |
| H | ASN150 | |
| H | ASN184 | |
| I | GLY83 | |
| I | LYS127 | |
| I | ASN150 | |
| I | ASN184 | |
| J | GLY83 | |
| J | LYS127 | |
| J | ASN150 | |
| A | ASN184 | |
| J | ASN184 | |
| K | GLY83 | |
| K | LYS127 | |
| K | ASN150 | |
| K | ASN184 | |
| L | GLY83 | |
| L | LYS127 | |
| L | ASN150 | |
| L | ASN184 | |
| M | GLY83 | |
| B | GLY83 | |
| M | LYS127 | |
| M | ASN150 | |
| M | ASN184 | |
| N | GLY83 | |
| N | LYS127 | |
| N | ASN150 | |
| N | ASN184 | |
| O | GLY83 | |
| O | LYS127 | |
| O | ASN150 | |
| B | LYS127 | |
| O | ASN184 | |
| P | GLY83 | |
| P | LYS127 | |
| P | ASN150 | |
| P | ASN184 | |
| B | ASN150 | |
| B | ASN184 | |
| C | GLY83 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H78 |
| Chain | Residue | Details |
| A | ASP104 | |
| J | ASP104 | |
| K | ASP104 | |
| L | ASP104 | |
| M | ASP104 | |
| N | ASP104 | |
| O | ASP104 | |
| P | ASP104 | |
| B | ASP104 | |
| C | ASP104 | |
| D | ASP104 | |
| E | ASP104 | |
| F | ASP104 | |
| G | ASP104 | |
| H | ASP104 | |
| I | ASP104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 64 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5IAA, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H77, ECO:0007744|PDB:6H78 |
| Chain | Residue | Details |
| A | CYS226 | |
| C | CYS229 | |
| C | CYS303 | |
| C | CYS308 | |
| D | CYS226 | |
| D | CYS229 | |
| D | CYS303 | |
| D | CYS308 | |
| E | CYS226 | |
| E | CYS229 | |
| E | CYS303 | |
| A | CYS229 | |
| E | CYS308 | |
| F | CYS226 | |
| F | CYS229 | |
| F | CYS303 | |
| F | CYS308 | |
| G | CYS226 | |
| G | CYS229 | |
| G | CYS303 | |
| G | CYS308 | |
| H | CYS226 | |
| A | CYS303 | |
| H | CYS229 | |
| H | CYS303 | |
| H | CYS308 | |
| I | CYS226 | |
| I | CYS229 | |
| I | CYS303 | |
| I | CYS308 | |
| J | CYS226 | |
| J | CYS229 | |
| J | CYS303 | |
| A | CYS308 | |
| J | CYS308 | |
| K | CYS226 | |
| K | CYS229 | |
| K | CYS303 | |
| K | CYS308 | |
| L | CYS226 | |
| L | CYS229 | |
| L | CYS303 | |
| L | CYS308 | |
| M | CYS226 | |
| B | CYS226 | |
| M | CYS229 | |
| M | CYS303 | |
| M | CYS308 | |
| N | CYS226 | |
| N | CYS229 | |
| N | CYS303 | |
| N | CYS308 | |
| O | CYS226 | |
| O | CYS229 | |
| O | CYS303 | |
| B | CYS229 | |
| O | CYS308 | |
| P | CYS226 | |
| P | CYS229 | |
| P | CYS303 | |
| P | CYS308 | |
| B | CYS303 | |
| B | CYS308 | |
| C | CYS226 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER45 | |
| J | SER45 | |
| K | SER45 | |
| L | SER45 | |
| M | SER45 | |
| N | SER45 | |
| O | SER45 | |
| P | SER45 | |
| B | SER45 | |
| C | SER45 | |
| D | SER45 | |
| E | SER45 | |
| F | SER45 | |
| G | SER45 | |
| H | SER45 | |
| I | SER45 |
