6H78
E1 enzyme for ubiquitin like protein activation.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
B | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
C | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
D | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
E | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
F | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
G | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
H | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
I | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
J | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
K | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
L | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
M | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
N | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
O | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
P | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | binding site for residue ATP A 401 |
Chain | Residue |
A | GLY80 |
A | ASN150 |
A | ILE151 |
A | THR152 |
A | CYS181 |
A | ASP183 |
A | ASN184 |
A | ALA187 |
A | MG402 |
A | MG404 |
A | HOH501 |
A | GLY82 |
A | HOH502 |
A | HOH511 |
A | HOH520 |
A | HOH526 |
A | HOH544 |
A | HOH545 |
B | ARG55 |
A | GLY83 |
A | ASP104 |
A | TYR105 |
A | ASP106 |
A | ASN112 |
A | ARG115 |
A | LYS127 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue MG A 402 |
Chain | Residue |
A | ASP183 |
A | ATP401 |
A | HOH502 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN A 403 |
Chain | Residue |
A | CYS226 |
A | CYS229 |
A | CYS303 |
A | CYS308 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue MG A 404 |
Chain | Residue |
A | ASP106 |
A | ATP401 |
A | HOH501 |
A | HOH503 |
A | HOH526 |
A | HOH567 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue EDO A 405 |
Chain | Residue |
A | ASN210 |
A | ASP240 |
A | GLU241 |
A | LYS242 |
A | THR243 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue EDO A 406 |
Chain | Residue |
A | PRO301 |
A | ARG309 |
A | GLN312 |
A | GLU313 |
A | LYS316 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue EDO A 407 |
Chain | Residue |
A | MET189 |
A | ASN192 |
A | THR193 |
A | ASP305 |
site_id | AC8 |
Number of Residues | 23 |
Details | binding site for residue ATP B 401 |
Chain | Residue |
A | ARG55 |
B | GLY80 |
B | GLY82 |
B | GLY83 |
B | ASP104 |
B | TYR105 |
B | ASP106 |
B | ASN112 |
B | ARG115 |
B | LYS127 |
B | TYR149 |
B | ASN150 |
B | ILE151 |
B | THR152 |
B | CYS181 |
B | VAL182 |
B | ASP183 |
B | ASN184 |
B | MG402 |
B | MG404 |
B | HOH519 |
B | HOH524 |
B | HOH537 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue MG B 402 |
Chain | Residue |
B | ASP183 |
B | ATP401 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue ZN B 403 |
Chain | Residue |
B | CYS226 |
B | CYS229 |
B | CYS303 |
B | CYS308 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue MG B 404 |
Chain | Residue |
A | HOH539 |
B | ASP106 |
B | ATP401 |
B | HOH504 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue EDO B 405 |
Chain | Residue |
A | GLN119 |
B | THR134 |
E | GLY36 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue EDO B 406 |
Chain | Residue |
B | PHE272 |
B | LEU273 |
B | ASN275 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue EDO B 407 |
Chain | Residue |
B | THR152 |
B | PHE157 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue EDO B 408 |
Chain | Residue |
B | PHE281 |
B | MET295 |
site_id | AD7 |
Number of Residues | 1 |
Details | binding site for residue EDO B 409 |
Chain | Residue |
B | HOH505 |
site_id | AD8 |
Number of Residues | 24 |
Details | binding site for residue ATP C 401 |
Chain | Residue |
C | GLY83 |
C | ASP104 |
C | TYR105 |
C | ASP106 |
C | ASN112 |
C | ARG115 |
C | LYS127 |
C | ASN150 |
C | ILE151 |
C | THR152 |
C | CYS181 |
C | VAL182 |
C | ASP183 |
C | ASN184 |
C | ALA187 |
C | MET258 |
C | MG402 |
C | MG404 |
C | HOH511 |
C | HOH517 |
C | HOH523 |
D | ARG55 |
C | GLY80 |
C | GLY82 |
site_id | AD9 |
Number of Residues | 2 |
Details | binding site for residue MG C 402 |
Chain | Residue |
C | ASP183 |
C | ATP401 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue ZN C 403 |
Chain | Residue |
C | CYS226 |
C | CYS229 |
C | CYS303 |
C | CYS308 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue MG C 404 |
Chain | Residue |
C | ASP106 |
C | LYS127 |
C | ATP401 |
C | HOH501 |
C | HOH517 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue EDO C 405 |
Chain | Residue |
C | SER213 |
C | GLY214 |
C | HIS215 |
C | VAL235 |
site_id | AE4 |
Number of Residues | 23 |
Details | binding site for residue ATP D 401 |
Chain | Residue |
C | ARG55 |
D | GLY80 |
D | GLY82 |
D | GLY83 |
D | ASP104 |
D | TYR105 |
D | ASP106 |
D | ASN112 |
D | ARG115 |
D | LYS127 |
D | TYR149 |
D | ASN150 |
D | ILE151 |
D | ASP183 |
D | ASN184 |
D | MG402 |
D | MG404 |
D | EDO405 |
D | HOH502 |
D | HOH503 |
D | HOH509 |
D | HOH510 |
D | HOH515 |
site_id | AE5 |
Number of Residues | 3 |
Details | binding site for residue MG D 402 |
Chain | Residue |
D | ASP183 |
D | ATP401 |
D | HOH503 |
site_id | AE6 |
Number of Residues | 4 |
Details | binding site for residue ZN D 403 |
Chain | Residue |
D | CYS226 |
D | CYS229 |
D | CYS303 |
D | CYS308 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue MG D 404 |
Chain | Residue |
D | ASP106 |
D | ATP401 |
D | HOH511 |
D | HOH537 |
site_id | AE8 |
Number of Residues | 6 |
Details | binding site for residue EDO D 405 |
Chain | Residue |
D | GLY83 |
D | VAL84 |
D | CYS181 |
D | ASP183 |
D | ATP401 |
D | HOH506 |
site_id | AE9 |
Number of Residues | 1 |
Details | binding site for residue EDO D 406 |
Chain | Residue |
D | GLN129 |
site_id | AF1 |
Number of Residues | 3 |
Details | binding site for residue EDO D 407 |
Chain | Residue |
D | HIS121 |
D | HIS133 |
D | THR134 |
site_id | AF2 |
Number of Residues | 22 |
Details | binding site for residue ATP E 401 |
Chain | Residue |
E | GLY80 |
E | GLY82 |
E | GLY83 |
E | ASP104 |
E | TYR105 |
E | ASP106 |
E | ASN112 |
E | ARG115 |
E | LYS127 |
E | ASN150 |
E | ILE151 |
E | THR152 |
E | CYS181 |
E | ASP183 |
E | ASN184 |
E | MG402 |
E | MG404 |
E | HOH501 |
E | HOH502 |
E | HOH516 |
E | HOH536 |
F | ARG55 |
site_id | AF3 |
Number of Residues | 2 |
Details | binding site for residue MG E 402 |
Chain | Residue |
E | ASP183 |
E | ATP401 |
site_id | AF4 |
Number of Residues | 4 |
Details | binding site for residue ZN E 403 |
Chain | Residue |
E | CYS226 |
E | CYS229 |
E | CYS303 |
E | CYS308 |
site_id | AF5 |
Number of Residues | 4 |
Details | binding site for residue MG E 404 |
Chain | Residue |
E | ASP106 |
E | ATP401 |
E | HOH501 |
E | HOH540 |
site_id | AF6 |
Number of Residues | 3 |
Details | binding site for residue EDO E 405 |
Chain | Residue |
E | GLU223 |
E | SER296 |
E | MET297 |
site_id | AF7 |
Number of Residues | 3 |
Details | binding site for residue EDO E 406 |
Chain | Residue |
E | PRO301 |
E | ARG309 |
E | GLN312 |
site_id | AF8 |
Number of Residues | 27 |
Details | binding site for residue ATP F 401 |
Chain | Residue |
E | ARG55 |
F | GLY80 |
F | GLY82 |
F | GLY83 |
F | ASP104 |
F | TYR105 |
F | ASP106 |
F | ASN112 |
F | ARG115 |
F | LYS127 |
F | TYR149 |
F | ASN150 |
F | ILE151 |
F | THR152 |
F | ASP183 |
F | ASN184 |
F | ALA187 |
F | MET258 |
F | MG402 |
F | MG404 |
F | HOH502 |
F | HOH507 |
F | HOH520 |
F | HOH524 |
F | HOH531 |
F | HOH534 |
F | HOH536 |
site_id | AF9 |
Number of Residues | 3 |
Details | binding site for residue MG F 402 |
Chain | Residue |
F | ASP183 |
F | ATP401 |
F | HOH502 |
site_id | AG1 |
Number of Residues | 4 |
Details | binding site for residue ZN F 403 |
Chain | Residue |
F | CYS226 |
F | CYS229 |
F | CYS303 |
F | CYS308 |
site_id | AG2 |
Number of Residues | 4 |
Details | binding site for residue MG F 404 |
Chain | Residue |
F | ASP106 |
F | ATP401 |
F | HOH507 |
F | HOH536 |
site_id | AG3 |
Number of Residues | 3 |
Details | binding site for residue EDO F 405 |
Chain | Residue |
A | GLY36 |
F | ASN137 |
F | HOH526 |
site_id | AG4 |
Number of Residues | 4 |
Details | binding site for residue EDO F 406 |
Chain | Residue |
F | GLY284 |
F | TYR285 |
F | ASN286 |
F | PRO293 |
site_id | AG5 |
Number of Residues | 2 |
Details | binding site for residue EDO F 407 |
Chain | Residue |
F | GLU223 |
F | MET297 |
site_id | AG6 |
Number of Residues | 23 |
Details | binding site for residue ATP G 401 |
Chain | Residue |
G | GLY80 |
G | GLY82 |
G | GLY83 |
G | ASP104 |
G | TYR105 |
G | ASP106 |
G | ASN112 |
G | ARG115 |
G | LYS127 |
G | TYR149 |
G | ASN150 |
G | ILE151 |
G | THR152 |
G | CYS181 |
G | VAL182 |
G | ASP183 |
G | ASN184 |
G | MG402 |
G | MG404 |
G | HOH503 |
G | HOH514 |
G | HOH520 |
H | ARG55 |
site_id | AG7 |
Number of Residues | 3 |
Details | binding site for residue MG G 402 |
Chain | Residue |
G | ASP183 |
G | ATP401 |
G | HOH503 |
site_id | AG8 |
Number of Residues | 4 |
Details | binding site for residue ZN G 403 |
Chain | Residue |
G | CYS226 |
G | CYS229 |
G | CYS303 |
G | CYS308 |
site_id | AG9 |
Number of Residues | 4 |
Details | binding site for residue MG G 404 |
Chain | Residue |
G | ASP106 |
G | LYS127 |
G | ATP401 |
G | HOH550 |
site_id | AH1 |
Number of Residues | 3 |
Details | binding site for residue EDO G 405 |
Chain | Residue |
G | ASN196 |
G | GLU197 |
G | ASN307 |
site_id | AH2 |
Number of Residues | 6 |
Details | binding site for residue EDO G 406 |
Chain | Residue |
G | VAL175 |
G | ASP176 |
G | GLY199 |
G | GLN200 |
G | EDO407 |
G | HOH502 |
site_id | AH3 |
Number of Residues | 3 |
Details | binding site for residue EDO G 407 |
Chain | Residue |
G | LEU198 |
G | GLY199 |
G | EDO406 |
site_id | AH4 |
Number of Residues | 27 |
Details | binding site for residue ATP H 401 |
Chain | Residue |
G | ARG55 |
H | GLY80 |
H | GLY82 |
H | GLY83 |
H | ASP104 |
H | TYR105 |
H | ASP106 |
H | ASN112 |
H | ARG115 |
H | LYS127 |
H | ASN150 |
H | ILE151 |
H | THR152 |
H | CYS181 |
H | VAL182 |
H | ASP183 |
H | ASN184 |
H | ALA187 |
H | MG402 |
H | MG404 |
H | HOH510 |
H | HOH511 |
H | HOH520 |
H | HOH521 |
H | HOH525 |
H | HOH535 |
H | HOH537 |
site_id | AH5 |
Number of Residues | 2 |
Details | binding site for residue MG H 402 |
Chain | Residue |
H | ASP183 |
H | ATP401 |
site_id | AH6 |
Number of Residues | 4 |
Details | binding site for residue ZN H 403 |
Chain | Residue |
H | CYS226 |
H | CYS229 |
H | CYS303 |
H | CYS308 |
site_id | AH7 |
Number of Residues | 5 |
Details | binding site for residue MG H 404 |
Chain | Residue |
H | ASP106 |
H | ATP401 |
H | HOH511 |
H | HOH521 |
H | HOH525 |
site_id | AH8 |
Number of Residues | 4 |
Details | binding site for residue EDO H 405 |
Chain | Residue |
G | GLU90 |
G | PHE117 |
H | PHE117 |
H | GLN119 |
site_id | AH9 |
Number of Residues | 26 |
Details | binding site for residue ATP I 400 |
Chain | Residue |
I | GLY80 |
I | GLY82 |
I | GLY83 |
I | ASP104 |
I | TYR105 |
I | ASP106 |
I | ASN112 |
I | ARG115 |
I | LYS127 |
I | TYR149 |
I | ASN150 |
I | ILE151 |
I | THR152 |
I | CYS181 |
I | ASP183 |
I | ASN184 |
I | MG401 |
I | MG403 |
I | HOH505 |
I | HOH520 |
I | HOH521 |
I | HOH528 |
I | HOH530 |
I | HOH540 |
I | HOH541 |
J | ARG55 |
site_id | AI1 |
Number of Residues | 3 |
Details | binding site for residue MG I 401 |
Chain | Residue |
I | ASP183 |
I | ATP400 |
I | HOH546 |
site_id | AI2 |
Number of Residues | 4 |
Details | binding site for residue ZN I 402 |
Chain | Residue |
I | CYS226 |
I | CYS229 |
I | CYS303 |
I | CYS308 |
site_id | AI3 |
Number of Residues | 6 |
Details | binding site for residue MG I 403 |
Chain | Residue |
I | ASP106 |
I | ATP400 |
I | HOH501 |
I | HOH504 |
I | HOH505 |
I | HOH540 |
site_id | AI4 |
Number of Residues | 23 |
Details | binding site for residue ATP J 401 |
Chain | Residue |
I | ARG55 |
J | GLY80 |
J | GLY82 |
J | GLY83 |
J | ASP104 |
J | TYR105 |
J | ASP106 |
J | ARG115 |
J | LYS127 |
J | ASN150 |
J | ILE151 |
J | CYS181 |
J | VAL182 |
J | ASP183 |
J | ASN184 |
J | MG402 |
J | MG404 |
J | HOH503 |
J | HOH505 |
J | HOH516 |
J | HOH529 |
J | HOH531 |
J | HOH540 |
site_id | AI5 |
Number of Residues | 3 |
Details | binding site for residue MG J 402 |
Chain | Residue |
J | ASP183 |
J | ATP401 |
J | HOH529 |
site_id | AI6 |
Number of Residues | 4 |
Details | binding site for residue ZN J 403 |
Chain | Residue |
J | CYS226 |
J | CYS229 |
J | CYS303 |
J | CYS308 |
site_id | AI7 |
Number of Residues | 6 |
Details | binding site for residue MG J 404 |
Chain | Residue |
J | ASP106 |
J | LYS127 |
J | ATP401 |
J | HOH505 |
J | HOH506 |
J | HOH531 |
site_id | AI8 |
Number of Residues | 7 |
Details | binding site for residue EDO J 405 |
Chain | Residue |
D | HIS121 |
J | HIS121 |
J | GLN122 |
J | HIS133 |
J | THR134 |
J | HOH513 |
J | HOH543 |
site_id | AI9 |
Number of Residues | 6 |
Details | binding site for residue EDO J 406 |
Chain | Residue |
I | GLU90 |
I | PHE117 |
I | GLN119 |
J | GLU90 |
J | PHE117 |
J | GLN119 |
site_id | AJ1 |
Number of Residues | 1 |
Details | binding site for residue EDO J 407 |
Chain | Residue |
J | TYR105 |
site_id | AJ2 |
Number of Residues | 2 |
Details | binding site for residue EDO J 408 |
Chain | Residue |
J | PHE272 |
J | ASN275 |
site_id | AJ3 |
Number of Residues | 3 |
Details | binding site for residue EDO J 409 |
Chain | Residue |
J | PRO301 |
J | ARG309 |
J | LYS316 |
site_id | AJ4 |
Number of Residues | 5 |
Details | binding site for residue EDO J 410 |
Chain | Residue |
J | VAL279 |
J | SER280 |
J | PHE281 |
J | THR294 |
J | MET295 |
site_id | AJ5 |
Number of Residues | 24 |
Details | binding site for residue ATP K 401 |
Chain | Residue |
K | GLY80 |
K | GLY82 |
K | GLY83 |
K | ASP104 |
K | TYR105 |
K | ASP106 |
K | ASN112 |
K | ARG115 |
K | LYS127 |
K | ASN150 |
K | ILE151 |
K | THR152 |
K | CYS181 |
K | VAL182 |
K | ASP183 |
K | ASN184 |
K | ALA187 |
K | MG402 |
K | MG404 |
K | HOH501 |
K | HOH516 |
K | HOH533 |
K | HOH535 |
L | ARG55 |
site_id | AJ6 |
Number of Residues | 3 |
Details | binding site for residue MG K 402 |
Chain | Residue |
K | ASP183 |
K | ATP401 |
K | HOH501 |
site_id | AJ7 |
Number of Residues | 4 |
Details | binding site for residue ZN K 403 |
Chain | Residue |
K | CYS226 |
K | CYS229 |
K | CYS303 |
K | CYS308 |
site_id | AJ8 |
Number of Residues | 6 |
Details | binding site for residue MG K 404 |
Chain | Residue |
K | ASP106 |
K | ATP401 |
K | HOH508 |
K | HOH509 |
K | HOH540 |
K | HOH544 |
site_id | AJ9 |
Number of Residues | 3 |
Details | binding site for residue EDO K 405 |
Chain | Residue |
K | PRO301 |
K | GLU313 |
K | LYS316 |
site_id | AK1 |
Number of Residues | 1 |
Details | binding site for residue CL K 407 |
Chain | Residue |
K | ASN156 |
site_id | AK2 |
Number of Residues | 22 |
Details | binding site for residue ATP L 401 |
Chain | Residue |
K | ARG55 |
L | GLY80 |
L | GLY82 |
L | GLY83 |
L | ASP104 |
L | TYR105 |
L | ASP106 |
L | ASN112 |
L | ARG115 |
L | LYS127 |
L | ASN150 |
L | ILE151 |
L | CYS181 |
L | VAL182 |
L | ASP183 |
L | ASN184 |
L | ALA187 |
L | MG402 |
L | MG404 |
L | HOH501 |
L | HOH502 |
L | HOH539 |
site_id | AK3 |
Number of Residues | 3 |
Details | binding site for residue MG L 402 |
Chain | Residue |
L | ASP183 |
L | ATP401 |
L | HOH501 |
site_id | AK4 |
Number of Residues | 4 |
Details | binding site for residue ZN L 403 |
Chain | Residue |
L | CYS226 |
L | CYS229 |
L | CYS303 |
L | CYS308 |
site_id | AK5 |
Number of Residues | 5 |
Details | binding site for residue MG L 404 |
Chain | Residue |
L | ASP106 |
L | LYS127 |
L | ATP401 |
L | HOH520 |
L | HOH537 |
site_id | AK6 |
Number of Residues | 3 |
Details | binding site for residue EDO L 405 |
Chain | Residue |
L | GLN129 |
L | HOH509 |
P | ARG136 |
site_id | AK7 |
Number of Residues | 2 |
Details | binding site for residue EDO L 406 |
Chain | Residue |
L | ASN196 |
L | GLU197 |
site_id | AK8 |
Number of Residues | 5 |
Details | binding site for residue EDO L 407 |
Chain | Residue |
L | PRO174 |
L | VAL175 |
L | ASP176 |
L | HOH505 |
L | HOH538 |
site_id | AK9 |
Number of Residues | 21 |
Details | binding site for residue ATP M 401 |
Chain | Residue |
M | GLY80 |
M | GLY82 |
M | GLY83 |
M | ASP104 |
M | TYR105 |
M | ASP106 |
M | ASN112 |
M | ARG115 |
M | LYS127 |
M | ASN150 |
M | ILE151 |
M | CYS181 |
M | VAL182 |
M | ASP183 |
M | ASN184 |
M | MET258 |
M | MG402 |
M | MG404 |
M | HOH501 |
M | HOH526 |
N | ARG55 |
site_id | AL1 |
Number of Residues | 3 |
Details | binding site for residue MG M 402 |
Chain | Residue |
M | ASP183 |
M | ATP401 |
M | HOH501 |
site_id | AL2 |
Number of Residues | 4 |
Details | binding site for residue ZN M 403 |
Chain | Residue |
M | CYS226 |
M | CYS229 |
M | CYS303 |
M | CYS308 |
site_id | AL3 |
Number of Residues | 4 |
Details | binding site for residue MG M 404 |
Chain | Residue |
M | ASP106 |
M | ATP401 |
M | HOH533 |
M | HOH537 |
site_id | AL4 |
Number of Residues | 1 |
Details | binding site for residue EDO M 405 |
Chain | Residue |
M | ASN148 |
site_id | AL5 |
Number of Residues | 2 |
Details | binding site for residue EDO M 406 |
Chain | Residue |
M | SER296 |
M | MET297 |
site_id | AL6 |
Number of Residues | 25 |
Details | binding site for residue ATP N 401 |
Chain | Residue |
M | ARG55 |
N | GLY80 |
N | GLY82 |
N | GLY83 |
N | ASP104 |
N | TYR105 |
N | ASP106 |
N | ASN112 |
N | ARG115 |
N | LYS127 |
N | ASN150 |
N | ILE151 |
N | THR152 |
N | CYS181 |
N | VAL182 |
N | ASP183 |
N | ASN184 |
N | MG402 |
N | MG404 |
N | HOH506 |
N | HOH511 |
N | HOH516 |
N | HOH517 |
N | HOH519 |
N | HOH524 |
site_id | AL7 |
Number of Residues | 2 |
Details | binding site for residue MG N 402 |
Chain | Residue |
N | ASP183 |
N | ATP401 |
site_id | AL8 |
Number of Residues | 4 |
Details | binding site for residue ZN N 403 |
Chain | Residue |
N | CYS226 |
N | CYS229 |
N | CYS303 |
N | CYS308 |
site_id | AL9 |
Number of Residues | 6 |
Details | binding site for residue MG N 404 |
Chain | Residue |
N | ASP106 |
N | ATP401 |
N | HOH511 |
N | HOH517 |
N | HOH523 |
N | HOH526 |
site_id | AM1 |
Number of Residues | 2 |
Details | binding site for residue EDO N 405 |
Chain | Residue |
N | GLU155 |
N | HIS159 |
site_id | AM2 |
Number of Residues | 26 |
Details | binding site for residue ATP O 401 |
Chain | Residue |
O | GLY80 |
O | GLY82 |
O | GLY83 |
O | ASP104 |
O | TYR105 |
O | ASP106 |
O | ASN112 |
O | ARG115 |
O | LYS127 |
O | TYR149 |
O | ASN150 |
O | ILE151 |
O | THR152 |
O | CYS181 |
O | VAL182 |
O | ASP183 |
O | ASN184 |
O | ALA187 |
O | MG402 |
O | MG404 |
O | HOH517 |
O | HOH520 |
O | HOH524 |
O | HOH526 |
O | HOH528 |
P | ARG55 |
site_id | AM3 |
Number of Residues | 2 |
Details | binding site for residue MG O 402 |
Chain | Residue |
O | ASP183 |
O | ATP401 |
site_id | AM4 |
Number of Residues | 4 |
Details | binding site for residue ZN O 403 |
Chain | Residue |
O | CYS226 |
O | CYS229 |
O | CYS303 |
O | CYS308 |
site_id | AM5 |
Number of Residues | 6 |
Details | binding site for residue MG O 404 |
Chain | Residue |
O | ASP106 |
O | ATP401 |
O | HOH519 |
O | HOH520 |
O | HOH524 |
O | HOH526 |
site_id | AM6 |
Number of Residues | 4 |
Details | binding site for residue EDO O 405 |
Chain | Residue |
O | PHE117 |
O | GLN119 |
P | GLU90 |
P | PHE117 |
site_id | AM7 |
Number of Residues | 3 |
Details | binding site for residue EDO O 406 |
Chain | Residue |
O | GLU223 |
O | MET297 |
O | LYS298 |
site_id | AM8 |
Number of Residues | 2 |
Details | binding site for residue EDO O 407 |
Chain | Residue |
O | GLU155 |
O | ASN156 |
site_id | AM9 |
Number of Residues | 27 |
Details | binding site for residue ATP P 401 |
Chain | Residue |
O | ARG55 |
P | GLY80 |
P | GLY82 |
P | GLY83 |
P | ASP104 |
P | TYR105 |
P | ASP106 |
P | ASN112 |
P | ARG115 |
P | LYS127 |
P | TYR149 |
P | ASN150 |
P | ILE151 |
P | THR152 |
P | CYS181 |
P | VAL182 |
P | ASP183 |
P | ASN184 |
P | ALA187 |
P | MG402 |
P | MG404 |
P | EDO405 |
P | HOH504 |
P | HOH509 |
P | HOH511 |
P | HOH516 |
P | HOH517 |
site_id | AN1 |
Number of Residues | 2 |
Details | binding site for residue MG P 402 |
Chain | Residue |
P | ASP183 |
P | ATP401 |
site_id | AN2 |
Number of Residues | 4 |
Details | binding site for residue ZN P 403 |
Chain | Residue |
P | CYS226 |
P | CYS229 |
P | CYS303 |
P | CYS308 |
site_id | AN3 |
Number of Residues | 5 |
Details | binding site for residue MG P 404 |
Chain | Residue |
P | ASP106 |
P | LYS127 |
P | ATP401 |
P | HOH516 |
P | HOH527 |
site_id | AN4 |
Number of Residues | 2 |
Details | binding site for residue EDO P 405 |
Chain | Residue |
P | ALA251 |
P | ATP401 |
site_id | AN5 |
Number of Residues | 3 |
Details | binding site for residue EDO P 406 |
Chain | Residue |
P | SER213 |
P | HIS215 |
P | VAL235 |
site_id | AN6 |
Number of Residues | 2 |
Details | binding site for residue EDO P 407 |
Chain | Residue |
P | GLU223 |
P | MET297 |
site_id | AN7 |
Number of Residues | 5 |
Details | binding site for residue EDO P 408 |
Chain | Residue |
B | PHE291 |
P | ASN286 |
P | GLN289 |
P | PHE291 |
P | HOH521 |
Functional Information from PROSITE/UniProt
site_id | PS00065 |
Number of Residues | 29 |
Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VAIVGvGGVGsvtaemltrcgigkLLlFD |
Chain | Residue | Details |
A | VAL76-ASP104 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:34588452 |
Chain | Residue | Details |
A | CYS250 | |
J | CYS250 | |
K | CYS250 | |
L | CYS250 | |
M | CYS250 | |
N | CYS250 | |
O | CYS250 | |
P | CYS250 | |
B | CYS250 | |
C | CYS250 | |
D | CYS250 | |
E | CYS250 | |
F | CYS250 | |
G | CYS250 | |
H | CYS250 | |
I | CYS250 |
site_id | SWS_FT_FI2 |
Number of Residues | 64 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H77, ECO:0007744|PDB:6H78 |
Chain | Residue | Details |
A | GLY83 | |
C | LYS127 | |
C | ASN150 | |
C | ASN184 | |
D | GLY83 | |
D | LYS127 | |
D | ASN150 | |
D | ASN184 | |
E | GLY83 | |
E | LYS127 | |
E | ASN150 | |
A | LYS127 | |
E | ASN184 | |
F | GLY83 | |
F | LYS127 | |
F | ASN150 | |
F | ASN184 | |
G | GLY83 | |
G | LYS127 | |
G | ASN150 | |
G | ASN184 | |
H | GLY83 | |
A | ASN150 | |
H | LYS127 | |
H | ASN150 | |
H | ASN184 | |
I | GLY83 | |
I | LYS127 | |
I | ASN150 | |
I | ASN184 | |
J | GLY83 | |
J | LYS127 | |
J | ASN150 | |
A | ASN184 | |
J | ASN184 | |
K | GLY83 | |
K | LYS127 | |
K | ASN150 | |
K | ASN184 | |
L | GLY83 | |
L | LYS127 | |
L | ASN150 | |
L | ASN184 | |
M | GLY83 | |
B | GLY83 | |
M | LYS127 | |
M | ASN150 | |
M | ASN184 | |
N | GLY83 | |
N | LYS127 | |
N | ASN150 | |
N | ASN184 | |
O | GLY83 | |
O | LYS127 | |
O | ASN150 | |
B | LYS127 | |
O | ASN184 | |
P | GLY83 | |
P | LYS127 | |
P | ASN150 | |
P | ASN184 | |
B | ASN150 | |
B | ASN184 | |
C | GLY83 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H78 |
Chain | Residue | Details |
A | ASP104 | |
J | ASP104 | |
K | ASP104 | |
L | ASP104 | |
M | ASP104 | |
N | ASP104 | |
O | ASP104 | |
P | ASP104 | |
B | ASP104 | |
C | ASP104 | |
D | ASP104 | |
E | ASP104 | |
F | ASP104 | |
G | ASP104 | |
H | ASP104 | |
I | ASP104 |
site_id | SWS_FT_FI4 |
Number of Residues | 64 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:30412706, ECO:0007744|PDB:5IAA, ECO:0007744|PDB:5L95, ECO:0007744|PDB:6H77, ECO:0007744|PDB:6H78 |
Chain | Residue | Details |
A | CYS226 | |
C | CYS229 | |
C | CYS303 | |
C | CYS308 | |
D | CYS226 | |
D | CYS229 | |
D | CYS303 | |
D | CYS308 | |
E | CYS226 | |
E | CYS229 | |
E | CYS303 | |
A | CYS229 | |
E | CYS308 | |
F | CYS226 | |
F | CYS229 | |
F | CYS303 | |
F | CYS308 | |
G | CYS226 | |
G | CYS229 | |
G | CYS303 | |
G | CYS308 | |
H | CYS226 | |
A | CYS303 | |
H | CYS229 | |
H | CYS303 | |
H | CYS308 | |
I | CYS226 | |
I | CYS229 | |
I | CYS303 | |
I | CYS308 | |
J | CYS226 | |
J | CYS229 | |
J | CYS303 | |
A | CYS308 | |
J | CYS308 | |
K | CYS226 | |
K | CYS229 | |
K | CYS303 | |
K | CYS308 | |
L | CYS226 | |
L | CYS229 | |
L | CYS303 | |
L | CYS308 | |
M | CYS226 | |
B | CYS226 | |
M | CYS229 | |
M | CYS303 | |
M | CYS308 | |
N | CYS226 | |
N | CYS229 | |
N | CYS303 | |
N | CYS308 | |
O | CYS226 | |
O | CYS229 | |
O | CYS303 | |
B | CYS229 | |
O | CYS308 | |
P | CYS226 | |
P | CYS229 | |
P | CYS303 | |
P | CYS308 | |
B | CYS303 | |
B | CYS308 | |
C | CYS226 |
site_id | SWS_FT_FI5 |
Number of Residues | 16 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER45 | |
J | SER45 | |
K | SER45 | |
L | SER45 | |
M | SER45 | |
N | SER45 | |
O | SER45 | |
P | SER45 | |
B | SER45 | |
C | SER45 | |
D | SER45 | |
E | SER45 | |
F | SER45 | |
G | SER45 | |
H | SER45 | |
I | SER45 |