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PDB: 60 results

1FQZ
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NMR VALIDATED MODEL OF DOMAIN IIID OF HEPATITIS C VIRUS INTERNAL RIBOSOME ENTRY SITE
Descriptor: HEPATITIS C VIRUS IRES DOMAIN IIID
Authors:Klinck, R, Westhof, E, Walker, S, Afshar, M, Collier, A, Aboul-ela, F.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A potential RNA drug target in the hepatitis C virus internal ribosomal entry site.
RNA, 6, 2000
5J02
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Structure of the lariat form of a chimeric derivative of the Oceanobacillus iheyensis group II intron in the presence of NH4+, MG2+ and an inactive 5' exon.
Descriptor: 5' EXON ANALOG (5'-R(*CP*UP*GP*UP*UP*AP*(5MU))-3'), AMMONIUM ION, GROUP II INTRON LARIAT, ...
Authors:Costa, M, Walbott, H, Monachello, D, Westhof, E, Michel, F.
Deposit date:2016-03-26
Release date:2016-12-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.493 Å)
Cite:Crystal structures of a group II intron lariat primed for reverse splicing.
Science, 354, 2016
1J7T
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Complex between Paromomycin and the 16S-rRNA A-site at 2.5 A resolution
Descriptor: 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', PAROMOMYCIN
Authors:Vicens, Q, Westhof, E.
Deposit date:2001-05-18
Release date:2002-05-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site.
Structure, 9, 2001
1DN5
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SOLVATION OF THE LEFT-HANDED HEXAMER D(5BRC-G-5BRC-G-5BRC-G) IN CRYSTALS GROWN AT TWO TEMPERATURES
Descriptor: DNA (5'-D(*(CBR)P*GP*(CBR)P*GP*(CBR)P*G)-3')
Authors:Chevrier, B, Dock, A.C, Hartmann, B, Leng, M, Moras, D, Thuong, M.T, Westhof, E.
Deposit date:1986-12-01
Release date:1987-04-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Solvation of the left-handed hexamer d(5BrC-G-5BrC-G-5 BrC-G) in crystals grown at two temperatures.
J.Mol.Biol., 188, 1986
1DN4
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SOLVATION OF THE LEFT-HANDED HEXAMER D(5BRC-G-5BRC-G-5BRC-G) IN CRYSTALS GROWN AT TWO TEMPERATURES
Descriptor: DNA (5'-D(*(CBR)P*GP*(CBR)P*GP*(CBR)P*G)-3')
Authors:Chevrier, B, Dock, A.C, Hartmann, B, Leng, M, Moras, D, Thuong, M.T, Westhof, E.
Deposit date:1986-12-01
Release date:1987-04-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Solvation of the left-handed hexamer d(5BrC-G-5BrC-G-5 BrC-G) in crystals grown at two temperatures.
J.Mol.Biol., 188, 1986
1DN8
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STRUCTURE OF A Z-DNA WITH TWO DIFFERENT BACKBONE CHAIN CONFORMATIONS. STABILIZATION OF THE DECADEOXYOLIGONUCLEOTIDE D(CGTACGTACG) BY (CO(NH3)6)3+ BINDING TO THE GUANINE
Descriptor: COBALT HEXAMMINE(III), DNA (5'-D(*P*CP*GP*TP*AP*CP*GP*TP*AP*CP*G)-3')
Authors:Brennan, R.G, Westhof, E, Sundaralingam, M.
Deposit date:1987-05-12
Release date:1988-04-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a Z-DNA with two different backbone chain conformations. Stabilization of the decadeoxyoligonucleotide d(CGTACGTACG) by [Co(NH3)6]3+ binding to the guanine.
J.Biomol.Struct.Dyn., 3, 1986
1MWL
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Crystal structure of geneticin bound to the eubacterial 16S rRNA A site
Descriptor: 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', GENETICIN
Authors:Vicens, Q, Westhof, E.
Deposit date:2002-09-30
Release date:2003-02-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide
J.Mol.Biol., 326, 2003
2BE0
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Complex Between Paromomycin Derivative JS5-39 and the 16S-Rrna A-Site.
Descriptor: (2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,4R,5S,6R)-3-AMINO-4 ,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-(HYDROXYMETHYL)-4-(2-((R)-PIPERIDI N-3-YLMETHYLAMINO)ETHOXY)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL, 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
Authors:Francois, B, Westhof, E.
Deposit date:2005-10-21
Release date:2005-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site
ANGEW.CHEM.INT.ED.ENGL., 43, 2004
2BEE
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Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site
Descriptor: (2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-4-(2-(3-AMINOPROPYLAMINO)ETHOXY)-5-((1R,2R,3S,5R,6S)-3,5-DIAM INO-2-((2S,3R,4R,5S,6R)-3-AMINO-4,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-( HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL, 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
Authors:Francois, B, Westhof, E.
Deposit date:2005-10-24
Release date:2005-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site
ANGEW.CHEM.INT.ED.ENGL., 43, 2004
4V7E
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BU of 4v7e by Molmil
Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S10E, ...
Authors:Barrio-Garcia, C, Armache, J.-P, Jarasch, A, Anger, A.M, Villa, E, Becker, T, Bhushan, S, Jossinet, F, Habeck, M, Dindar, G, Franckenberg, S, Marquez, V, Mielke, T, Thomm, M, Berninghausen, O, Beatrix, B, Soeding, J, Westhof, E, Wilson, D.N, Beckmann, R.
Deposit date:2013-11-22
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
Nature, 506, 2014
3S4P
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Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue
Descriptor: (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-2-O-{2-[(2-phenylethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3')
Authors:Szychowski, J, Kondo, J, Zahr, O, Auclair, K, Westhof, E, Hanessian, S, Keillor, J.W.
Deposit date:2011-05-20
Release date:2011-09-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues
Chemmedchem, 6, 2011
1VTD
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BU of 1vtd by Molmil
UNUSUAL HELICAL PACKING IN CRYSTALS OF DNA BEARING A MUTATION HOT SPOT
Descriptor: DNA (5'-D(*AP*CP*CP*GP*GP*CP*GP*CP*CP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*GP*GP*CP*GP*CP*CP*GP*GP*T)-3')
Authors:Timsit, Y, Westhof, E, Fuchs, R.P.P, Moras, D.
Deposit date:1996-12-12
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Unusual helical packing in crystals of DNA bearing a mutation hot spot.
Nature, 341, 1989
4P8Z
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Speciation of a group I intron into a lariat capping ribozyme
Descriptor: Didymium iridis partial IGS, 18S rRNA gene, I-DirI gene and partial ITS1
Authors:Meyer, M, Nielsen, H, Olieric, V, Roblin, P, Johansen, S.D, Westhof, E, Masquida, B.
Deposit date:2014-04-01
Release date:2014-05-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Speciation of a group I intron into a lariat capping ribozyme.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P20
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Crystal structures of the bacterial ribosomal decoding site complexed with amikacin
Descriptor: (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
Authors:Kondo, J, Francois, B, Russell, R.J.M, Murray, J.B, Westhof, E.
Deposit date:2014-02-28
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group.
Biochimie, 88, 2006
4P9R
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Speciation of a group I intron into a lariat capping ribozyme (Heavy atom derivative)
Descriptor: IRIDIUM HEXAMMINE ION, MAGNESIUM ION, RNA (189-MER)
Authors:Meyer, M, Nielsen, H, Olieric, V, Roblin, P, Johansen, S.D, Westhof, E, Masquida, B.
Deposit date:2014-04-04
Release date:2014-05-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Speciation of a group I intron into a lariat capping ribozyme.
Proc.Natl.Acad.Sci.USA, 111, 2014
2PWT
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BU of 2pwt by Molmil
Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group
Descriptor: 22-mer of the ribosomal decoding site, DOUBLY FUNCTIONALIZED PAROMOMYCIN PM-II-162
Authors:Kondo, J, Pachamuthu, K, Francois, B, Szychowski, J, Hanessian, S, Westhof, E.
Deposit date:2007-05-13
Release date:2007-09-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity
Chemmedchem, 2, 2007
1LC4
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BU of 1lc4 by Molmil
Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site
Descriptor: 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', TOBRAMYCIN
Authors:Vicens, Q, Westhof, E.
Deposit date:2002-04-05
Release date:2003-04-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal Structure of a Complex between the Aminoglycoside Tobramycin and an Oligonucleotide Containing the Ribosomal Decoding A Site
Chem.Biol., 9, 2002
6GYV
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BU of 6gyv by Molmil
Lariat-capping ribozyme (circular permutation form)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lariat-capping ribozyme, MAGNESIUM ION, ...
Authors:Masquida, B, Meyer, M, Nielsen, H, Olieric, V, Roblin, P, Johansen, S.D, Westhof, E.
Deposit date:2018-07-02
Release date:2018-08-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.50003624 Å)
Cite:Speciation of a group I intron into a lariat capping ribozyme.
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
1KOC
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BU of 1koc by Molmil
RNA APTAMER COMPLEXED WITH ARGININE, NMR
Descriptor: ARGININE, RNA (5'-R(P*AP*CP*AP*GP*GP*UP*AP*GP*GP*UP*CP*GP*CP*U)-3'), RNA (5'-R(P*AP*GP*AP*AP*GP*GP*AP*GP*CP*GP*U)-3')
Authors:Yang, Y.S, Kochoyan, M, Burgstaller, P, Westhof, E, Famulok, M.
Deposit date:1996-03-28
Release date:1996-08-17
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy.
Science, 272, 1996
1KOD
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BU of 1kod by Molmil
RNA APTAMER COMPLEXED WITH CITRULLINE, NMR
Descriptor: CITRULLINE, RNA (5'-R(P*AP*CP*GP*GP*UP*UP*AP*GP*GP*UP*CP*GP*CP*U)-3'), RNA (5'-R(P*AP*GP*AP*AP*GP*GP*AP*GP*UP*GP*U)-3')
Authors:Yang, Y.S, Kochoyan, M, Burgstaller, P, Westhof, E, Famulok, M.
Deposit date:1996-03-28
Release date:1996-11-08
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy.
Science, 272, 1996
2NOQ
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BU of 2noq by Molmil
Structure of ribosome-bound cricket paralysis virus IRES RNA
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S5, ...
Authors:Schuler, M, Connell, S.R, Lescoute, A, Giesebrecht, J, Dabrowski, M, Schroeer, B, Mielke, T, Penczek, P.A, Westhof, E, Spahn, C.M.T.
Deposit date:2006-10-26
Release date:2006-11-21
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Structure of the ribosome-bound cricket paralysis virus IRES RNA.
Nat.Struct.Mol.Biol., 13, 2006
2O3X
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Crystal Structure of the Prokaryotic Ribosomal Decoding Site Complexed with Paromamine Derivative NB30
Descriptor: (1R,2R,3S,4R,6S)-4,6-DIAMINO-2-[(5-AMINO-5-DEOXY-BETA-D-RIBOFURANOSYL)OXY]-3-HYDROXYCYCLOHEXYL 2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3')
Authors:Kondo, J, Hainrichson, M, Nudelman, I, Shallom-Shezifi, D, Baasov, T, Westhof, E.
Deposit date:2006-12-02
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites.
Chembiochem, 8, 2007
2O3V
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Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33
Descriptor: (2S,3R,4R,5S,6R)-3-AMINO-4-({[(2S,3R,4R,5S,6R)-3-AMINO-2-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-5-HYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-4-YL]OXY}METHOXY)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIOL, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3')
Authors:Kondo, J, Hainrichson, M, Nudelman, I, Shallom-Shezifi, D, Baasov, T, Westhof, E.
Deposit date:2006-12-02
Release date:2007-11-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites.
Chembiochem, 8, 2007
2O3W
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Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site in presence of paromomycin
Descriptor: PAROMOMYCIN, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3')
Authors:Kondo, J, Hainrichson, M, Nudelman, I, Shallom-Shezifi, D, Baasov, T, Westhof, E.
Deposit date:2006-12-02
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites.
Chembiochem, 8, 2007
2O3Y
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Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site in Presence of Paromamine Derivative NB30
Descriptor: RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'), SPERMINE
Authors:Kondo, J, Hainrichson, M, Nudelman, I, Shallom-Shezifi, D, Baasov, T, Westhof, E.
Deposit date:2006-12-02
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites.
Chembiochem, 8, 2007

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