1J7T

Complex between Paromomycin and the 16S-rRNA A-site at 2.5 A resolution

Summary for 1J7T

• Entry DOI: 10.2210/pdb1j7t/pdb
• Descriptor: 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', PAROMOMYCIN (3 entities in total)
• Functional Keywords: rna-aminoglycoside interactions, a site, uou pairs, aa bulges, rna
• Total number of polymer chains: 2
• Total formula weight: 15327.77

Authors

Vicens, Q.,Westhof, E. (deposition date: 2001-05-18, release date: 2002-05-18, Last modification date: 2024-04-03)

Primary citation

Vicens, Q.,Westhof, E.
Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site.
Structure, 9:647-658, 2001

PubMed Abstract: Aminoglycoside antibiotics interfere with translation in both gram-positive and gram-negative bacteria by binding to the tRNA decoding A site of the 16S ribosomal RNA.

PubMed: 11587639
DOI: 10.1016/S0969-2126(01)00629-3

Experimental method

X-RAY DIFFRACTION (2.5 Å)