6E70
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![BU of 6e70 by Molmil](/molmil-images/mine/6e70) | Structure of Wild Type Human Transthyretin in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, CALCIUM ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.992 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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4P2S
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![BU of 4p2s by Molmil](/molmil-images/mine/4p2s) | Alanine Scanning Mutagenesis Identifies an Asparagine-Arginine-Lysine Triad Essential to Assembly of the Shell of the Pdu Microcompartment | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Putative propanediol utilization protein PduA, ... | Authors: | Sinha, S, Cheng, S, Sung, Y.W, McNamara, D.E, Sawaya, M.R, Yeates, T.O, Bobik, T.A. | Deposit date: | 2014-03-03 | Release date: | 2014-05-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Alanine Scanning Mutagenesis Identifies an Asparagine-Arginine-Lysine Triad Essential to Assembly of the Shell of the Pdu Microcompartment. J.Mol.Biol., 426, 2014
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6E73
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![BU of 6e73 by Molmil](/molmil-images/mine/6e73) | Structure of Human Transthyretin Val30Met Mutant in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, ACETATE ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.797 Å) | Cite: | Structural Variants of Transthyretin to be published
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6E76
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![BU of 6e76 by Molmil](/molmil-images/mine/6e76) | Structure of Human Transthyretin Asp38Ala/Thr119Met Mutant | Descriptor: | ACETATE ION, GLYCEROL, SULFATE ION, ... | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E72
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![BU of 6e72 by Molmil](/molmil-images/mine/6e72) | Structure of Human Transthyretin Val30Met Mutant in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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2RIH
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![BU of 2rih by Molmil](/molmil-images/mine/2rih) | CBS domain protein PAE2072 from Pyrobaculum aerophilum | Descriptor: | ACETIC ACID, Conserved protein with 2 CBS domains, SULFATE ION | Authors: | Lee, T.M, King, N.P, Sawaya, M.R, Cascio, D, Yeates, T.O. | Deposit date: | 2007-10-10 | Release date: | 2008-06-17 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures and Functional Implications of an AMP-Binding Cystathionine beta-Synthase Domain Protein from a Hyperthermophilic Archaeon J.Mol.Biol., 380, 2008
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3CIM
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![BU of 3cim by Molmil](/molmil-images/mine/3cim) | Carboxysome shell protein, CcmK2 C-terminal deletion mutant | Descriptor: | Carbon dioxide-concentrating mechanism protein ccmK homolog 2, GLYCEROL, SULFATE ION | Authors: | Tanaka, S, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2008-03-11 | Release date: | 2009-02-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Insights from multiple structures of the shell proteins from the beta-carboxysome. Protein Sci., 18, 2009
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3MLG
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![BU of 3mlg by Molmil](/molmil-images/mine/3mlg) | 2ouf-2x, a designed knotted protein | Descriptor: | 2X chimera of Helicobacter pylori protein HP0242 | Authors: | King, N.P, Sawaya, M.R, Jacobitz, A.W, Yeates, T.O. | Deposit date: | 2010-04-16 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structure and folding of a designed knotted protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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6C3S
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![BU of 6c3s by Molmil](/molmil-images/mine/6c3s) | |
3DNC
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![BU of 3dnc by Molmil](/molmil-images/mine/3dnc) | Carboxysome shell protein, CcmK2 C-terminal deletion mutant, with a closer spacing between hexamers | Descriptor: | Carbon dioxide-concentrating mechanism protein ccmK homolog 2, GLYCEROL, SULFATE ION | Authors: | Tanaka, S, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2008-07-01 | Release date: | 2009-01-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Insights from multiple structures of the shell proteins from the beta-carboxysome. Protein Sci., 18, 2009
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3MLI
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![BU of 3mli by Molmil](/molmil-images/mine/3mli) | 2ouf-ds, a disulfide-linked dimer of Helicobacter pylori protein HP0242 | Descriptor: | CALCIUM ION, Putative uncharacterized protein | Authors: | King, N.P, Sawaya, M.R, Jacobitz, A.W, Yeates, T.O. | Deposit date: | 2010-04-16 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure and folding of a designed knotted protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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3Q29
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![BU of 3q29 by Molmil](/molmil-images/mine/3q29) | Cyrstal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP) | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ... | Authors: | Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2010-12-19 | Release date: | 2011-06-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation Protein Sci., 20, 2011
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4ONK
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![BU of 4onk by Molmil](/molmil-images/mine/4onk) | [Leu-5]-Enkephalin mutant - YVVFL | Descriptor: | [Leu-5]-Enkephalin mutant - YVVFL | Authors: | Sangwan, S, Eisenberg, D, Sawaya, M.R, Do, T.D, Bowers, M.T, Lapointe, N.E, Teplow, D.B, Feinstein, S.C. | Deposit date: | 2014-01-28 | Release date: | 2014-07-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Factors that drive Peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. J.Phys.Chem.B, 118, 2014
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6C4O
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![BU of 6c4o by Molmil](/molmil-images/mine/6c4o) | |
4PPD
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![BU of 4ppd by Molmil](/molmil-images/mine/4ppd) | PduA K26A, crystal form 2 | Descriptor: | GLYCEROL, Propanediol utilization protein PduA, SULFATE ION | Authors: | McNamara, D.E, Sawaya, M.R, Bobik, T.A, Yeates, T.O. | Deposit date: | 2014-02-26 | Release date: | 2014-05-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Alanine scanning mutagenesis identifies an asparagine-arginine-lysine triad essential to assembly of the shell of the pdu microcompartment. J.Mol.Biol., 426, 2014
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6E75
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![BU of 6e75 by Molmil](/molmil-images/mine/6e75) | Structure of Human Transthyretin Asp38Ala Mutant | Descriptor: | ACETATE ION, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E71
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![BU of 6e71 by Molmil](/molmil-images/mine/6e71) | Structure of Human Transthyretin Val30Met/Thr119Met Mutant | Descriptor: | DI(HYDROXYETHYL)ETHER, Transthyretin | Authors: | Saelices, L, Chung, K, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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6E78
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![BU of 6e78 by Molmil](/molmil-images/mine/6e78) | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin | Authors: | Chung, K, Saelices, L, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2018-07-25 | Release date: | 2019-07-31 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.499 Å) | Cite: | Structural Variants of Transthyretin To Be Published
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4TL5
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![BU of 4tl5 by Molmil](/molmil-images/mine/4tl5) | Crystal Structure of Human Transthyretin Ser85Pro Mutant | Descriptor: | CHLORIDE ION, SODIUM ION, Transthyretin | Authors: | Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. | Deposit date: | 2014-05-28 | Release date: | 2015-10-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
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4TKW
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![BU of 4tkw by Molmil](/molmil-images/mine/4tkw) | |
4TL4
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![BU of 4tl4 by Molmil](/molmil-images/mine/4tl4) | |
3SGR
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![BU of 3sgr by Molmil](/molmil-images/mine/3sgr) | Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L | Authors: | Laganowsky, A, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2011-06-15 | Release date: | 2012-03-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Atomic view of a toxic amyloid small oligomer. Science, 335, 2012
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3G7W
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![BU of 3g7w by Molmil](/molmil-images/mine/3g7w) | Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding Protein | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein, ... | Authors: | Wiltzius, J.J.W, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2009-02-11 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process Protein Sci., 18, 2009
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4TNE
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![BU of 4tne by Molmil](/molmil-images/mine/4tne) | Crystal Structure of Human Transthyretin Thr119Tyr Mutant | Descriptor: | GLYCEROL, Transthyretin | Authors: | Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. | Deposit date: | 2014-06-03 | Release date: | 2015-10-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
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4OIJ
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![BU of 4oij by Molmil](/molmil-images/mine/4oij) | X-ray crystal structure of racemic non-glycosylated chemokine Ser-CCL1 | Descriptor: | C-C motif chemokine 1, D-Ser-CCL1, SULFATE ION | Authors: | Okamoto, R, Mandal, K, Sawaya, M.R, Kajihara, Y, Yeates, T.O, Kent, S.B.H. | Deposit date: | 2014-01-19 | Release date: | 2014-05-07 | Last modified: | 2014-05-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | (Quasi-)Racemic X-ray Structures of Glycosylated and Non-Glycosylated Forms of the Chemokine Ser-CCL1 Prepared by Total Chemical Synthesis. Angew.Chem.Int.Ed.Engl., 53, 2014
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