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PDB: 5052 件

3P1J
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Crystal structure of human GTPase IMAP family member 2 in the nucleotide-free state
分子名称: GTPase IMAP family member 2, UNKNOWN ATOM OR ION
著者Shen, L, Tempel, W, Tong, Y, Guan, X, Nedyalkova, L, Wernimont, A.K, Mackenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Andrews, D.W, Park, H, Structural Genomics Consortium (SGC)
登録日2010-09-30
公開日2010-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Crystal structure of human GTPase IMAP family member 2 in the nucleotide-free state
to be published
2JEO
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Crystal structure of human uridine-cytidine kinase 1
分子名称: URIDINE-CYTIDINE KINASE 1
著者Kosinska, U, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E.P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Uppsten, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2007-01-18
公開日2007-01-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Human Uridine-Cytidine Kinase 1
To be Published
2JFK
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Structure of the MAT domain of human FAS with malonyl-CoA
分子名称: COENZYME A, FATTY ACID SYNTHASE
著者Bunkoczi, G, Kavanagh, K, Hozjan, V, Rojkova, A, Watt, S, Wu, X, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Weigelt, J, Smith, S, Oppermann, U.
登録日2007-02-02
公開日2007-03-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of the MAT Domain of Human Fas with Malonyl-Coa
To be Published
3FZV
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Crystal structure of PA01 protein, putative LysR family transcriptional regulator from Pseudomonas aeruginosa
分子名称: Probable transcriptional regulator, SULFATE ION
著者Knapik, A.A, Tkaczuk, K.L, Chruszcz, M, Wang, S, Zimmerman, M.D, Cymborowski, M, Skarina, T, Kagan, O, Savchenko, A, Edwards, A.M, Joachimiak, A, Bujnicki, J.M, Minor, W, Midwest Center for Structural Genomics (MCSG)
登録日2009-01-26
公開日2009-03-10
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystal structure of PA01 protein, putative LysR family transcriptional regulator from Pseudomonas aeruginosa
To be Published
3FXT
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Crystal structure of the N-terminal domain of human NUDT6
分子名称: GLYCEROL, Nucleoside diphosphate-linked moiety X motif 6
著者Tresaugues, L, Welin, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Siponen, M.I, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Wikstrom, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2009-01-21
公開日2009-03-03
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the N-terminal domain of human NUDT6
To be Published
3P1F
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Crystal structure of the bromodomain of human CREBBP in complex with a hydroquinazolin ligand
分子名称: 1,2-ETHANEDIOL, 3-methyl-3,4-dihydroquinazolin-2(1H)-one, CREB-binding protein, ...
著者Filippakopoulos, P, Picaud, S, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2010-09-30
公開日2010-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Crystal structure of the bromodomain of human CREBBP in complex with a hydroquinazolin ligand
To be Published
3G2G
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S437Y Mutant of human muscle pyruvate kinase, isoform M2
分子名称: Pyruvate kinase isozymes M1/M2, SULFATE ION, UNKNOWN ATOM OR ION
著者Hong, B, Dimov, S, Allali-Hassani, A, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, c, Weigelt, J, Bochkarev, A, Vedadi, M, Park, H, Structural Genomics Consortium (SGC)
登録日2009-01-31
公開日2009-03-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献S437Y Mutant of human muscle pyruvate kinase, isoform M2
To be Published
3G1U
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Crystal structure of Leishmania major S-adenosylhomocysteine hydrolase
分子名称: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Siponen, M.I, Welin, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Wisniewska, M, Schueler, H, Structural Genomics Consortium (SGC)
登録日2009-01-30
公開日2009-02-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of Leishmania major S-adenosylhomocysteine hydrolase
To be Published
4RCJ
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Crystal structure of YTHDF1 YTH domain in complex with 5mer m6A RNA
分子名称: RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION, YTH domain-containing family protein 1
著者Tempel, W, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-09-16
公開日2014-11-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
J.Biol.Chem., 290, 2015
2H16
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Structure of human ADP-ribosylation factor-like 5 (ARL5)
分子名称: ADP-ribosylation factor-like protein 5A, GUANOSINE-5'-DIPHOSPHATE, UNKNOWN ATOM OR ION
著者Rabeh, W.M, Tempel, W, Yaniw, D, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2006-05-16
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of human ADP-ribosylation factor-like 5 (ARL5)
To be Published
2H2Y
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Crystal structure of ubiquitin conjugating enzyme E2 from plasmodium falciparum
分子名称: Ubiquitin-conjugating enzyme
著者Qiu, W, Dong, A, Zhao, Y, Lew, J, Kozieradski, I, Sundararajan, E, Melone, M, Wasney, G, Vedadi, M, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC)
登録日2006-05-19
公開日2006-06-20
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
3SMS
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Human Pantothenate kinase 3 in complex with a pantothenate analog
分子名称: (2R)-N-[3-(heptylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide, ADENOSINE-5'-DIPHOSPHATE, Pantothenate kinase 3, ...
著者Mottaghi, K, Tempel, W, Hong, B, Smil, D, Bolshan, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
登録日2011-06-28
公開日2011-07-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Human Pantothenate kinase 3 in complex with a pantothenate analog
to be published
4MEP
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BU of 4mep by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand
分子名称: 3-chloro-5-[1-(3-methylpyridin-2-yl)-3-phenyl-1H-1,2,4-triazol-5-yl]pyridin-2(1H)-one, Bromodomain-containing protein 4
著者Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, Vidler, L.R, Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Hoelder, S, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-08-27
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening.
J.Med.Chem., 56, 2013
4R3H
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The crystal structure of an apo RNA binding protein
分子名称: SULFATE ION, UNKNOWN ATOM OR ION, YTH domain-containing protein 1
著者Xu, C, Liu, K, Tempel, W, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-08-15
公開日2014-09-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.
Nat.Chem.Biol., 10, 2014
2GSF
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The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region
分子名称: Ephrin type-A receptor 3
著者Walker, J.R, Davis, T, Dong, A, Newman, E.M, MacKenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2006-04-26
公開日2006-06-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structure Of The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region
To be Published
3TNJ
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Crystal structure of universal stress protein from Nitrosomonas europaea with AMP bound
分子名称: ADENOSINE MONOPHOSPHATE, Universal stress protein (Usp)
著者Tkaczuk, K.L, Chruszcz, M, Shumilin, I.A, Evdokimova, E, Kagan, O, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
登録日2011-09-01
公開日2011-09-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional insight into the universal stress protein family.
Evol Appl, 6, 2013
3SN5
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Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one
分子名称: (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, Cholesterol 7-alpha-monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Strushkevich, N, Tempel, W, MacKenzie, F, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
登録日2011-06-28
公開日2011-07-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one
To be Published
3BHY
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Crystal structure of human death associated protein kinase 3 (DAPK3) in complex with a beta-carboline ligand
分子名称: (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile, CHLORIDE ION, Death-associated protein kinase 3
著者Filippakopoulos, P, Rellos, P, Eswaran, J, Fedorov, O, Berridge, G, Niesen, F, Bracher, F, Huber, K, Pike, A.C.W, Roos, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC)
登録日2007-11-29
公開日2007-12-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.
J.Med.Chem., 55, 2012
2H5G
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Crystal structure of human pyrroline-5-carboxylate synthetase
分子名称: Delta 1-pyrroline-5-carboxylate synthetase, SULFATE ION
著者Papagrigoriou, E, Shafqat, N, Turnbull, A.P, Berridge, G, Hozjan, V, Kavanagh, K, Gileadi, O, Smee, C, Bray, J, Gorrec, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2006-05-26
公開日2006-06-23
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of human pyrroline-5-carboxylate synthetase
To be published
2JI4
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Human phosphoribosylpyrophosphate synthetase - associated protein 41 (PAP41)
分子名称: CHLORIDE ION, PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE-ASSOCIATED PROTEIN 2
著者Moche, M, Lehtio, L, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg-Schiavone, L, Johansson, I, Karlberg, T, Kotenyova, T, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Nordlund, P.
登録日2007-02-26
公開日2007-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Human Phosphoribosylpyrophosphate Synthetase -Associated Protein 41 (Pap41)
To be Published
3QTD
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Crystal structure of putative modulator of gyrase (PmbA) from Pseudomonas aeruginosa PAO1
分子名称: GLYCEROL, PmbA protein
著者Tkaczuk, K.L, Chruszcz, M, Evdokimova, E, Liu, F, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
登録日2011-02-22
公開日2011-03-30
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of putative modulator of gyrase (PmbA) from Pseudomonas aeruginosa PAO1
To be Published
3B7W
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Crystal structure of human acyl-CoA synthetase medium-chain family member 2A, with L64P mutation
分子名称: Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor, CHLORIDE ION, ...
著者Pilka, E.S, Kochan, G.T, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2007-10-31
公開日2007-11-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol., 388, 2009
4I79
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Crystal structure of human NUP43
分子名称: Nucleoporin Nup43, UNKNOWN ATOM OR ION, floating chain, ...
著者Xu, C, Tempel, W, Li, Z, He, H, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2012-11-30
公開日2013-02-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structure of human nuclear pore complex component NUP43.
Febs Lett., 589, 2015
2GUU
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crystal structure of Plasmodium vivax orotidine 5-monophosphate decarboxylase with 6-aza-UMP bound
分子名称: 6-AZA URIDINE 5'-MONOPHOSPHATE, ODcase
著者Dong, A, Lew, J, Zhao, Y, Sundararajan, E, Wasney, G, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Pai, E.F, Kotra, L, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC)
登録日2006-05-01
公開日2006-05-16
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Crystal structure of Plasmodium vivax orotidine 5-monophosphate decarboxylase with 6-aza-UMP bound
To be Published
2GRY
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Crystal structure of the human KIF2 motor domain in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2, MAGNESIUM ION, ...
著者Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2006-04-25
公開日2006-05-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the human KIF2 motor domain in complex with ADP
to be published

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