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PDB: 896 件
8HK3
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C3aR-Gi-apo protein complex
分子名称: C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E.
登録日2022-11-24
公開日2023-05-10
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.
Nat.Chem.Biol., 19, 2023
8HK2
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C3aR-Gi-C3a protein complex
分子名称: C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ...
著者Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E.
登録日2022-11-24
公開日2023-05-10
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.
Nat.Chem.Biol., 19, 2023
3QGC
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BU of 3qgc by Molmil
Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa A7U mutant
分子名称: 5'-R(*UP*GP*UP*GP*CP*CP*UP*UP*A)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Qiu, C, Koh, Y.Y, Opperman, L, Gross, L, Hall, T.M.T, Wickens, M.
登録日2011-01-24
公開日2011-03-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Stacking interactions in PUF-RNA complexes.
Rna, 17, 2011
3QGB
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BU of 3qgb by Molmil
Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa
分子名称: 5'-R(*UP*GP*UP*GP*CP*CP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Qiu, C, Koh, Y.Y, Opperman, L, Gross, L, Hall, T.M.T, Wickens, M.
登録日2011-01-24
公開日2011-03-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Stacking interactions in PUF-RNA complexes.
Rna, 17, 2011
5UHR
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Crystal structure of (Cit)LANFLV heptapeptide segment from islet amyloid polypeptide (IAPP) incorporated into a macrocyclic beta-sheet template
分子名称: CHLORIDE ION, ORN-CIR-LEU-ALA-ASN-PHE-LEU-VAL-ORN-ILE-LYS-HAO-LYS-A8E
著者Wang, Y, Kreutzer, A.G, Nowick, J.S.
登録日2017-01-11
公開日2017-07-12
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.798 Å)
主引用文献A Tetramer Derived from Islet Amyloid Polypeptide.
J. Org. Chem., 82, 2017
5V39
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Crystal structure of human vitamin D receptor ligand binding domain in complex with a VDRM
分子名称: 5-(3-{4-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-3-methylphenyl}pentan-3-yl)-3-methyl-N-(1H-tetrazol-5-yl)thiophene-2-carboxamide, Vitamin D3 receptor
著者Wang, Y, Pelletier, L.
登録日2017-03-06
公開日2018-03-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.
Nat Commun, 8, 2017
5UJT
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Crystal structure of human HLA-DQ8 in complex with insulin mimotope binding in register 3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-beta-1, ...
著者Wang, Y, Dai, S.
登録日2017-01-18
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3SO9
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Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 protease
著者Wang, Y, Liu, Z, Brunzelle, S.J, Kovari, L.C, Kovari, I.A.
登録日2011-06-30
公開日2011-10-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
Biochem.Biophys.Res.Commun., 412, 2011
2H4Z
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Human bisphosphoglycerate mutase complexed with 2,3-bisphosphoglycerate
分子名称: (2R)-2,3-diphosphoglyceric acid, Bisphosphoglycerate mutase
著者Wang, Y, Gong, W.
登録日2006-05-25
公開日2006-10-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase.
J.Biol.Chem., 281, 2006
2H4X
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Human bisphosphoglycerate mutase complex with 3-phosphoglycerate with crystal growth 90 days
分子名称: 3-PHOSPHOGLYCERIC ACID, Bisphosphoglycerate mutase
著者Wang, Y, Gong, W.
登録日2006-05-25
公開日2006-10-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase.
J.Biol.Chem., 281, 2006
6K3H
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BU of 6k3h by Molmil
Crystallographic Analysis of Nucleoside Diphosphate Kinase (NDK) from Aspergillus Flavus
分子名称: Nucleoside diphosphate kinase
著者Wang, Y, Wang, S, Wang, S.H.
登録日2019-05-18
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.179 Å)
主引用文献Molecular and structural basis of nucleoside diphosphate kinase-mediated regulation of spore and sclerotia development in the fungusAspergillus flavus.
J.Biol.Chem., 294, 2019
2HHJ
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BU of 2hhj by Molmil
Human bisphosphoglycerate mutase complexed with 2,3-bisphosphoglycerate (15 days)
分子名称: (2R)-2,3-diphosphoglyceric acid, 3-PHOSPHOGLYCERIC ACID, Bisphosphoglycerate mutase, ...
著者Wang, Y, Gong, W.
登録日2006-06-28
公開日2006-10-24
最終更新日2016-07-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase.
J.Biol.Chem., 281, 2006
8HBS
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BU of 8hbs by Molmil
Crystal of rAlfNmt
分子名称: Glycylpeptide N-tetradecanoyltransferase
著者Wang, Y, Wang, S.
登録日2022-10-30
公開日2023-03-08
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献N -Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus.
Microbiol Spectr, 11, 2023
8HJ4
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CryoEM structure of an anti-CRISPR protein AcrIIC5 bound to Nme1Cas9-sgRNA complex
分子名称: CRISPR-associated endonuclease Cas9, Phage protein, sgRNA
著者Wang, Y, Sun, W.
登録日2022-11-22
公開日2023-01-25
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition.
Nucleic Acids Res., 51, 2023
5XIW
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BU of 5xiw by Molmil
Crystal structure of T2R-TTL-Colchicine complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
著者Wang, Y, Yang, J, Wang, T, Chen, L.
登録日2017-04-27
公開日2018-04-18
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
5XP3
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Crystal structure of apo T2R-TTL
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
著者Wang, Y, Yang, J, Wang, T, Chen, L.
登録日2017-05-31
公開日2017-10-25
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
6BLQ
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BU of 6blq by Molmil
Crystal Structure of IAg7 in complex with insulin mimotope p8E9E
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wang, Y, Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLX
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Crystal structure of IAg7 in complex with insulin mimotope p8G9E
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wang, Y, Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.323 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLR
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BU of 6blr by Molmil
Crystal Structure of IAg7 in complex with insulin mimotope p8E9E6SS
分子名称: 1,2-ETHANEDIOL, H2-Ab1 protein, IAg7 alpha chain
著者Wang, Y, Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2019-12-11
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CCY
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Crystal structure of Akt1 in complex with a selective inhibitor
分子名称: (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one, RAC-alpha serine/threonine-protein kinase,PIFtide
著者Wang, Y, Stout, S.
登録日2018-02-07
公開日2018-05-02
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg. Med. Chem. Lett., 28, 2018
4IW2
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HSA-glucose complex
分子名称: D-glucose, PHOSPHATE ION, Serum albumin, ...
著者Wang, Y, Yu, H, Shi, X, Luo, Z, Huang, M.
登録日2013-01-23
公開日2013-04-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structural mechanism of ring-opening reaction of glucose by human serum albumin
J.Biol.Chem., 288, 2013
4IW1
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HSA-fructose complex
分子名称: D-fructose, PHOSPHATE ION, Serum albumin, ...
著者Wang, Y, Yu, H, Shi, X, Huang, M.
登録日2013-01-23
公開日2013-04-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structural mechanism of ring-opening reaction of glucose by human serum albumin
J.Biol.Chem., 288, 2013
6DFX
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human diabetogenic TCR T1D3 in complex with DQ8-p8E9E peptide
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wang, Y, Dai, S.
登録日2018-05-15
公開日2019-04-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
4JFJ
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Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound (1S,6R)-10-(1,3-benzothiazol-6-ylsulfonyl)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one
分子名称: (1S,6R)-10-(1,3-benzothiazol-6-ylsulfonyl)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5
著者Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F.
登録日2013-02-28
公開日2013-08-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
J.Med.Chem., 56, 2013
6DFQ
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mouse diabetogenic TCR I.29
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, TCR alpha chain, ...
著者Wang, Y, Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019

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