7KQU

A 1.58-A resolution crystal structure of ferric-hydroperoxo intermediate of L-tyrosine hydroxylase in complex with 3-fluoro-L-tyrosine

Summary for 7KQU

Entry DOI	10.2210/pdb7kqu/pdb
Descriptor	Heme-dependent L-tyrosine hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
Functional Keywords	heme-binding enzyme, l-tyrosine hydroxylase, oxidoreductase
Biological source	Streptomyces sclerotialus
Total number of polymer chains	2
Total formula weight	71276.92
Authors	Wang, Y.,Davis, I.,Liu, A. (deposition date: 2020-11-17, release date: 2021-03-31, Last modification date: 2023-10-18)
Primary citation	Wang, Y.,Davis, I.,Shin, I.,Xu, H.,Liu, A. Molecular Rationale for Partitioning between C-H and C-F Bond Activation in Heme-Dependent Tyrosine Hydroxylase. J.Am.Chem.Soc., 143:4680-4693, 2021 Cited by PubMed: 33734681 DOI: 10.1021/jacs.1c00175 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.579 Å)

Structure validation