8HTD
| Crystal structure of an effector from Chromobacterium violaceum in complex with ubiquitin | 分子名称: | NAD(+)--protein-threonine ADP-ribosyltransferase, Ubiquitin | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.848 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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8HTC
| Crystal structure of a SeMet-labeled effector from Chromobacterium violaceum in complex with Ubiquitin | 分子名称: | NAD(+)--protein-threonine ADP-ribosyltransferase, Ubiquitin-40S ribosomal protein S27a (Fragment) | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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8HTE
| Crystal structure of an effector mutant in complex with ubiquitin | 分子名称: | GLYCEROL, NAD(+)--protein-threonine ADP-ribosyltransferase, NICOTINAMIDE, ... | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.307 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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8HTF
| Crystal structure of an effector in complex with ubiquitin | 分子名称: | NAD(+)--protein-threonine ADP-ribosyltransferase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Ubiquitin-40S ribosomal protein S27a (Fragment) | 著者 | Tan, J, Wang, X, Zhou, Y, Zhu, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-22 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol., 20, 2024
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2MSV
| Solution structure of the MLKL N-terminal domain | 分子名称: | Mixed lineage kinase domain-like protein | 著者 | Su, L, Rizo, J, Quade, B, Wang, H, Sun, L, Wang, X. | 登録日 | 2014-08-07 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A Plug Release Mechanism for Membrane Permeation by MLKL. Structure, 22, 2014
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7ENA
| TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y. | 登録日 | 2021-04-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | 主引用文献 | Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
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7ENC
| TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y. | 登録日 | 2021-04-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
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7VHM
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2YG1
| APO STRUCTURE OF CELLOBIOHYDROLASE 1 (CEL7A) FROM HETEROBASIDION ANNOSUM | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CELLULOSE 1,4-BETA-CELLOBIOSIDASE, MAGNESIUM ION | 著者 | Haddad-Momeni, M, Hansson, H, Mikkelsen, N.E, Wang, X, Svedberg, J, Sandgren, M, Stahlberg, J. | 登録日 | 2011-04-11 | 公開日 | 2012-04-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare. J.Biol.Chem., 288, 2013
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8TW0
| Crystal Structure of a synthetic ABC heterotrimeric Collagen-like Peptide at 1.53 A | 分子名称: | Collagen Mimetic Peptide A, Collagen Mimetic Peptide B, Collagen Mimetic Peptide C, ... | 著者 | Miller, M.D, Cole, C.C, Xu, W, Walker, D.R, Hulgan, S.A.H, Pogostin, B.H, Swain, J.W.R, Duella, R, Misiura, M, Wang, X, Kolomeisky, A.B, Phillips Jr, G.N, Hartgerink, J.D. | 登録日 | 2023-08-18 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding. Nat.Chem., 2024
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2XSP
| Structure of Cellobiohydrolase 1 (Cel7A) from Heterobasidion annosum | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CELLULOSE 1,4-BETA-CELLOBIOSIDASE, ... | 著者 | Haddad-momeni, M, Hansson, H, Mikkelsen, N.E, Wang, X, Svedberg, J, Sandgren, M, Stahlberg, J. | 登録日 | 2010-09-29 | 公開日 | 2011-10-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural, Biochemical, and Computational Characterization of the Glycoside Hydrolase Family 7 Cellobiohydrolase of the Tree-Killing Fungus Heterobasidion Irregulare. J.Biol.Chem., 288, 2013
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2J14
| 3,4,5-Trisubstituted Isoxazoles as Novel PPARdelta Agonists: Part2 | 分子名称: | (3-{4-[2-(2,4-DICHLORO-PHENOXY)-ETHYLCARBAMOYL]-5-PHENYL-ISOXAZOL-3-YL}-PHENYL)-ACETIC ACID, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA | 著者 | Epple, R, Azimioara, M, Russo, R, Xie, Y, Wang, X, Cow, C, Wityak, J, Karanewsky, D, Bursulaya, B, Kreusch, A, Tuntland, T, Gerken, A, Iskandar, M, Saez, E, Seidel, H.M, Tian, S.S. | 登録日 | 2006-08-08 | 公開日 | 2006-09-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | 3,4,5-Trisubstituted Isoxazoles as Novel Ppardelta Agonists. Part 2 Bioorg.Med.Chem.Lett., 16, 2006
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6IJA
| Crystal Structure of Arabidopsis thaliana UGT89C1 complexed with UDP-L-rhamnose | 分子名称: | UDP-glycosyltransferase 89C1, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R},6~{S})-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate | 著者 | Zong, G, Wang, X. | 登録日 | 2018-10-09 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.214 Å) | 主引用文献 | Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP-beta-l-rhamnose and rhamnosylation mechanism. Plant J., 99, 2019
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6IJD
| Crystal Structure of Arabidopsis thaliana UGT89C1 complexed with quercetin | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, UDP-glycosyltransferase 89C1 | 著者 | Zong, G, Wang, X. | 登録日 | 2018-10-09 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.206 Å) | 主引用文献 | Crystal structures of rhamnosyltransferase UGT89C1 from Arabidopsis thaliana reveal the molecular basis of sugar donor specificity for UDP-beta-l-rhamnose and rhamnosylation mechanism. Plant J., 99, 2019
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2ZNV
| Crystal structure of human AMSH-LP DUB domain in complex with Lys63-linked ubiquitin dimer | 分子名称: | 1,2-ETHANEDIOL, AMSH-like protease, Ubiquitin, ... | 著者 | Sato, Y, Azusa, Y, Yamagata, A, Mimura, H, Wang, X, Yamashita, M, Ookata, K, Nureki, O, Iwai, K, Komada, M, Fukai, S. | 登録日 | 2008-05-01 | 公開日 | 2008-09-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Nature, 455, 2008
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2JXL
| Solution structure of cardiac N-domain troponin C mutant F77W-V82A | 分子名称: | CALCIUM ION, Troponin C, slow skeletal and cardiac muscles | 著者 | Julien, O, Sun, Y, Wang, X, Lindhout, D.A, Thiessen, A, Irving, M, Sykes, B.D. | 登録日 | 2007-11-20 | 公開日 | 2007-12-04 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Tryptophan Mutants of Cardiac Troponin C: 3D Structure, Troponin I Affinity, and in Situ Activity. Biochemistry, 47, 2008
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2ZNR
| Crystal structure of the DUB domain of human AMSH-LP | 分子名称: | 1,2-ETHANEDIOL, AMSH-like protease, PRASEODYMIUM ION, ... | 著者 | Sato, Y, Azusa, Y, Yamagata, A, Mimura, H, Wang, X, Yamashita, M, Ookata, K, Nureki, O, Iwai, K, Komada, M, Fukai, S. | 登録日 | 2008-05-01 | 公開日 | 2008-09-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Nature, 455, 2008
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8C15
| Aurora A kinase in complex with TPX2-inhibitor 3 | 分子名称: | (1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid, 4-(4-chlorophenyl)-1~{H}-indole-6-carboxylic acid, ACETATE ION, ... | 著者 | Fischer, G, Rocaboy, M, Blaszczyk, B, Moschetti, T, Wang, X, Scott, D.E, Coyne, A.G, Dagostin, C, Rooney, T, Bayly, A, Feng, J, Asteian, A, Alcaide-Lopez, A, Stockwell, S, Skidmore, J, Venkitaraman, A.R, Abell, C, Blundell, T.L, Hyvonen, M. | 登録日 | 2022-12-20 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents To be published
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8J6W
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7WYG
| Crystal structure of P450BSbeta-L78I/Q85H/G290I variant in complex with palmitic acid. | 分子名称: | Cytochrome P450 152A1, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | 著者 | Li, F, He, C, Wang, X. | 登録日 | 2022-02-16 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biocatalytic Enantioselective beta-Hydroxylation of Unactivated C-H Bonds in Aliphatic Carboxylic Acids. Angew.Chem.Int.Ed.Engl., 61, 2022
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6L1W
| Zinc-finger Antiviral Protein (ZAP) bound to RNA | 分子名称: | RNA (5'-R(*CP*GP*UP*CP*GP*U)-3'), ZINC ION, Zinc finger CCCH-type antiviral protein 1 | 著者 | Luo, X, Wang, X, Gao, Y, Zhu, J, Liu, S, Gao, G, Gao, P. | 登録日 | 2019-09-30 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | 主引用文献 | Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein. Cell Rep, 30, 2020
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8H8F
| Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR (resting state) | 分子名称: | Proton-activated chloride channel | 著者 | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | 登録日 | 2022-10-22 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR (resting state) To Be Published
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8H8E
| Structure of the dimeric Xenopus tropical acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (closed state) | 分子名称: | Proton-activated chloride channel, tRNA (75-MER)of Spodoptera frugiperda | 著者 | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | 登録日 | 2022-10-22 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Structure of the dimeric Xenopus tropical acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (closed state) To Be Published
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8H8D
| Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (intermediate state) | 分子名称: | Proton-activated chloride channel | 著者 | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | 登録日 | 2022-10-22 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.26 Å) | 主引用文献 | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (intermediate state) To Be Published
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8OR1
| Co-crystal strucutre of PD-L1 with low molecular weight inhibitor | 分子名称: | 5-[[5-[[2-chloranyl-3-(2-fluorophenyl)phenyl]methoxy]-2-[(~{E})-2-hydroxyethyliminomethyl]phenoxy]methyl]pyridine-3-carbonitrile, Programmed cell death 1 ligand 1 | 著者 | Zhang, H, Zhou, S, Wu, C, Zhu, M, Yu, Q, Wang, X, Awadasseid, A, Plewka, J, Magiera-Mularz, K, Wu, Y, Zhang, W. | 登録日 | 2023-04-12 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J.Med.Chem., 66, 2023
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