3UDJ
| Crystal Structure of BACE with Compound 5 | 分子名称: | 1,2-ETHANEDIOL, Beta-secretase 1, DI(HYDROXYETHYL)ETHER, ... | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | 登録日 | 2011-10-28 | 公開日 | 2012-04-18 | 最終更新日 | 2013-06-19 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
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3UDR
| Crystal Structure of BACE with Compound 14 | 分子名称: | 1,2-ETHANEDIOL, 1-cyanocyclohexyl (3S,5'R)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate, Beta-secretase 1, ... | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | 登録日 | 2011-10-28 | 公開日 | 2012-04-18 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
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3ESH
| Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314 | 分子名称: | Protein similar to metal-dependent hydrolase | 著者 | Seetharaman, J, Chen, Y, Wang, H, Janjua, H, Foote, E.L, Xiao, R, Nair, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-10-06 | 公開日 | 2008-10-28 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of a probable metal-dependent hydrolase from
Staphylococcus aureus. Northeast Structural Genomics target ZR314 To be Published
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4F7P
| Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009H1N1 PB1 (496-505) | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | 著者 | Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, Gao, G.F. | 登録日 | 2012-05-16 | 公開日 | 2012-10-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals. J.Virol., 86, 2012
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4FEK
| Crystal Structure of putative diflavin flavoprotein A 5 (fragment 1-254) from Nostoc sp. PCC 7120, Northeast Structural Genomics Consortium Target NsR435A , Northeast Structural Genomics Consortium (NESG) Target NsR435A | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | 著者 | Kuzin, A, Abashidze, M, Seetharaman, J, Janjua, J, Xiao, R, Foote, E.L, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-05-30 | 公開日 | 2012-07-11 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target NsR435A To be Published
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4ICZ
| HER2 1221/1222 phosphorylation regulated by PTPN9 | 分子名称: | HER2, Tyrosine-protein phosphatase non-receptor type 9 | 著者 | Xu, Y.F, Wang, H.M, Liu, C.H, Yu, X, Sun, J.P. | 登録日 | 2012-12-11 | 公開日 | 2013-12-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | HER2 1221/1222 phosphorylation regulated by PTPN9 To be Published
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3B57
| Crystal structure of the Lin1889 protein (Q92AN1) from Listeria innocua. Northeast Structural Consortium target LkR65 | 分子名称: | Lin1889 protein, MAGNESIUM ION | 著者 | Kuzin, A.P, Abashidze, M, Seetharaman, J, Benach, J, Forouhar, F, Vorobiev, S.M, Wang, H, Janjua, H, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-10-25 | 公開日 | 2007-11-06 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of the Lin1889 protein (Q92AN1) from Listeria innocua. To be Published
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3G3N
| PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one | 分子名称: | 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, MAGNESIUM ION, ... | 著者 | Castano, T, Wang, H. | 登録日 | 2009-02-02 | 公開日 | 2009-04-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors Chemmedchem, 4, 2009
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3TYH
| Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae | 分子名称: | COPPER (II) ION, FbpA protein | 著者 | Chen, W.J, Wang, H.F, Zhou, C.J, Ye, D.R, Huang, J, Tan, X.S, Zhong, W.Q. | 登録日 | 2011-09-26 | 公開日 | 2012-09-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae To be Published
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3QWE
| Crystal structure of the N-terminal domain of the GEM interacting protein | 分子名称: | GEM-interacting protein, UNKNOWN ATOM OR ION | 著者 | Guan, X, Tempel, W, Tong, Y, Shen, L, Wang, H, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-02-28 | 公開日 | 2011-03-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the N-terminal domain of the GEM interacting protein to be published
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6LXD
| Pri-miRNA bound DROSHA-DGCR8 complex | 分子名称: | Microprocessor complex subunit DGCR8, RNA (102-mer), Ribonuclease 3, ... | 著者 | Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M. | 登録日 | 2020-02-10 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural Basis for pri-miRNA Recognition by Drosha. Mol.Cell, 78, 2020
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6LYJ
| The crystal structure of SAUGI/EBVUDG complex | 分子名称: | SAUGI, Uracil-DNA glycosylase | 著者 | Liao, Y.T, Ko, T.P, Wang, H.C. | 登録日 | 2020-02-14 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases. Int.J.Biol.Macromol., 160, 2020
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5B1L
| The mouse nucleosome structure containing H3t | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1, ... | 著者 | Urahama, T, Machida, S, Horikoshi, N, Osakabe, A, Tachiwana, H, Taguchi, H, Kurumizaka, H. | 登録日 | 2015-12-08 | 公開日 | 2017-02-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis Cell Rep, 18, 2017
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6LXE
| DROSHA-DGCR8 complex | 分子名称: | Microprocessor complex subunit DGCR8, Ribonuclease 3, ZINC ION | 著者 | Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M. | 登録日 | 2020-02-10 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural Basis for pri-miRNA Recognition by Drosha. Mol.Cell, 78, 2020
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3LJX
| Crystal Structure of MmoQ Response regulator (fragment 20-298) from Methylococcus capsulatus str. Bath, Northeast Structural Genomics Consortium Target McR175G | 分子名称: | CHLORIDE ION, MmoQ Response regulator | 著者 | Kuzin, A, Scott, L, Forouhar, F, Abashidze, M, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-01-26 | 公開日 | 2010-02-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target McR175G To be published, 2009
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2Z8N
| Structural basis for the catalytic mechanism of phosphothreonine lyase | 分子名称: | 27.5 kDa virulence protein, SULFATE ION | 著者 | Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J. | 登録日 | 2007-09-07 | 公開日 | 2007-12-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for the catalytic mechanism of phosphothreonine lyase. Nat.Struct.Mol.Biol., 15, 2008
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2L5Q
| Solution NMR Structure of BVU_3817 from Bacteroides vulgatus, Northeast Structural Genomics Consortium Target BvR159 | 分子名称: | Uncharacterized protein | 著者 | Mills, J.L, Eletsky, A, Lee, H, Wang, H, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-11-03 | 公開日 | 2011-01-12 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Northeast Structural Genomics Consortium Target BvR159 To be Published
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3J0A
| Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction | 分子名称: | Toll-like receptor 5, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Modis, Y, Zhou, K, Kanai, R, Lee, P, Wang, H.W. | 登録日 | 2011-06-02 | 公開日 | 2011-12-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (26 Å) | 主引用文献 | Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin. J.Struct.Biol., 177, 2012
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4RHP
| Crystal structure of human COQ9 in complex with a phospholipid, Northeast Structural Genomics Consortium Target HR5043 | 分子名称: | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Ubiquinone biosynthesis protein COQ9, mitochondrial | 著者 | Forouhar, F, Lew, S, Seetharaman, J, Wang, H, Lee, D, Kogan, S, Maglaqui, M, Xiao, R, Everett, J.K, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG), Mitochondrial Protein Partnership (MPP) | 登録日 | 2014-10-02 | 公開日 | 2014-10-22 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | 主引用文献 | Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. Proc.Natl.Acad.Sci.USA, 111, 2014
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5H1B
| Human RAD51 presynaptic complex | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, MAGNESIUM ION, ... | 著者 | Xu, J, Zhao, L, Xu, Y, Zhao, W, Sung, P, Wang, H.W. | 登録日 | 2016-10-08 | 公開日 | 2016-12-21 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange Nat. Struct. Mol. Biol., 24, 2017
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7STW
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7WC6
| Crystal structure of serotonin 2A receptor in complex with LSD | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC9
| Crystal structure of serotonin 2A receptor in complex with non-hallucinogenic psychedelic analog | 分子名称: | (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5(16),6,8-triene, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC7
| Crystal structure of serotonin 2A receptor in complex with lisuride | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC8
| Crystal structure of serotonin 2A receptor in complex with lumateperone | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(10~{R},15~{S})-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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