3LZT
| REFINEMENT OF TRICLINIC LYSOZYME AT ATOMIC RESOLUTION | 分子名称: | ACETATE ION, LYSOZYME, NITRATE ION | 著者 | Walsh, M.A, Schneider, T, Sieker, L.C, Dauter, Z, Lamzin, V, Wilson, K.S. | 登録日 | 1997-03-23 | 公開日 | 1998-03-25 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (0.925 Å) | 主引用文献 | Refinement of triclinic hen egg-white lysozyme at atomic resolution. Acta Crystallogr.,Sect.D, 54, 1998
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1DW9
| Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site | 分子名称: | CHLORIDE ION, CYANATE LYASE, SULFATE ION | 著者 | Walsh, M.A, Otwinowski, Z, Perrakis, A, Anderson, P.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 1999-12-03 | 公開日 | 2000-05-16 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure of Cyanase Reveals that a Novel Dimeric and Decameric Arrangement of Subunits is Required for Formation of the Enzyme Active Site Structure, 8, 2000
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1DWK
| STRUCTURE OF CYANASE WITH THE DI-ANION OXALATE BOUND AT THE ENZYME ACTIVE SITE | 分子名称: | CYANATE HYDRATASE, OXALATE ION, SULFATE ION | 著者 | Walsh, M.A, Otwinowski, Z, Perrakis, A, Anderson, P.M, Joachimiak, A. | 登録日 | 1999-12-07 | 公開日 | 2000-05-16 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structure of Cyanase Reveals that a Novel Dimeric and Decameric Arrangement of Subunits is Required for Formation of the Enzyme Active Site. Structure, 8, 2000
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4LZT
| ATOMIC RESOLUTION REFINEMENT OF TRICLINIC HEW LYSOZYME AT 295K | 分子名称: | LYSOZYME, NITRATE ION | 著者 | Walsh, M.A, Schneider, T, Sieker, L.C, Dauter, Z, Lamzin, V, Wilson, K.S. | 登録日 | 1997-03-31 | 公開日 | 1998-04-01 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Refinement of triclinic hen egg-white lysozyme at atomic resolution. Acta Crystallogr.,Sect.D, 54, 1998
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8SNI
| Hydroxynitrile Lyase from Hevea brasiliensis with Forty Mutations | 分子名称: | (S)-hydroxynitrile lyase, 1,2-ETHANEDIOL, BENZOIC ACID, ... | 著者 | Walsh, M.E, Greenberg, L.R, Kazlauskas, R.J, Pierce, C.T, Aihara, H, Evans, R.L, Shi, K. | 登録日 | 2023-04-27 | 公開日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | To be published To Be Published
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1BU5
| X-RAY CRYSTAL STRUCTURE OF THE DESULFOVIBRIO VULGARIS (HILDENBOROUGH) APOFLAVODOXIN-RIBOFLAVIN COMPLEX | 分子名称: | PROTEIN (FLAVODOXIN), RIBOFLAVIN, SULFATE ION | 著者 | Walsh, M.A, Mccarthy, A, O'Farrell, P.A, Mccardle, P, Cunningham, P.D, Mayhew, S.G, Higgins, T.M. | 登録日 | 1998-09-12 | 公開日 | 1999-02-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | X-ray crystal structure of the Desulfovibrio vulgaris (Hildenborough) apoflavodoxin-riboflavin complex. Eur.J.Biochem., 258, 1998
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1AZL
| G61V FLAVODOXIN MUTANT FROM DESULFOVIBRIO VULGARIS | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | 著者 | Walsh, M.A, Mccarthy, A, O'Farrell, P.A, Voordouw, G, Higgins, T, Mayhew, S.G. | 登録日 | 1997-11-18 | 公開日 | 1998-05-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Modulation of the redox potentials of FMN in Desulfovibrio vulgaris flavodoxin: thermodynamic properties and crystal structures of glycine-61 mutants. Biochemistry, 37, 1998
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1SRV
| THERMUS THERMOPHILUS GROEL (HSP60 CLASS) FRAGMENT (APICAL DOMAIN) COMPRISING RESIDUES 192-336 | 分子名称: | PROTEIN (GROEL (HSP60 CLASS)) | 著者 | Walsh, M.A, Dementieva, I, Evans, G, Sanishvili, R, Joachimiak, A. | 登録日 | 1999-03-02 | 公開日 | 1999-03-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Taking MAD to the extreme: ultrafast protein structure determination. Acta Crystallogr.,Sect.D, 55, 1999
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7NW2
| Crystal Structure of SARS-CoV-2 main protease in complex with LON-WEI-adc59df6-47 | 分子名称: | 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Fearon, D, Douangamath, A, Aimon, A, Brandao-Neto, J, Dias, A, Dunnett, L, Gehrtz, P, Gorrie-Stone, T.J, Lukacik, P, Powell, A.J, Skyner, R, Strain-Damerell, C.M, Zaidman, D, London, N, Walsh, M.A, von Delft, F, Covid Moonshot Consortium | 登録日 | 2021-03-16 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M pro inhibitor. Cell Chem Biol, 28, 2021
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1C7F
| D95E OXIDIZED FLAVODOXIN MUTANT FROM D. VULGARIS | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | 著者 | McCarthy, A, Walsh, M, Higgins, T, D'Arcy, D. | 登録日 | 2000-02-11 | 公開日 | 2000-08-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystallographic Investigation of the Role of Aspartate 95 in the Modulation of the Redox Potentials Of Desulfovibrio Vulgaris Flavodoxin Biochemistry, 41, 2002
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1C7E
| D95E HYDROQUINONE FLAVODOXIN MUTANT FROM D. VULGARIS | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | 著者 | McCarthy, A, Walsh, M, Higgins, T, D'Arcy, D. | 登録日 | 2000-02-16 | 公開日 | 2000-08-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystallographic Investigation of the Role of Aspartate 95 in the Modulation of the Redox Potentials Of Desulfovibrio Vulgaris Flavodoxin Biochemistry, 41, 2002
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4B7G
| Structure of a bacterial catalase | 分子名称: | CATALASE, CHLORIDE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Gumiero, A, Walsh, M. | 登録日 | 2012-08-20 | 公開日 | 2013-08-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Structural and Dynamic Investigation of the Inhibition of Catalase by Nitric Oxide. Org.Biomol.Chem., 11, 2013
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4B7H
| Structure of a highdose liganded bacterial catalase | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CATALASE, CHLORIDE ION, ... | 著者 | Gumiero, A, Walsh, M. | 登録日 | 2012-08-20 | 公開日 | 2013-08-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | A Structural and Dynamic Investigation of the Inhibition of Catalase by Nitric Oxide. Org.Biomol.Chem., 11, 2013
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7Z59
| SARS-CoV-2 main protease (Mpro) covalently modified with a penicillin derivative | 分子名称: | (3S)-4-[[2,4-bis(fluoranyl)phenyl]methoxy]-2-methyl-4-oxidanylidene-3-[[(Z)-3-oxidanylidene-2-(2-phenoxyethanoylamino)prop-1-enyl]amino]butane-2-sulfinic acid, 1,2-ETHANEDIOL, 3C-like proteinase nsp5 | 著者 | Owen, C.D, Malla, T.R, Brewitz, L, Lukacik, P, Strain-Damerell, C, Mikolajek, H, Muntean, D.G, Aslam, H, Salah, E, Tumber, A, Schofield, C.J, Walsh, M.A. | 登録日 | 2022-03-08 | 公開日 | 2022-06-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine. J.Med.Chem., 65, 2022
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7Z4S
| Crystal structure of SARS-CoV-2 Mpro in complex with cyclic peptide GM4 including unnatural amino acids. | 分子名称: | 1,2-ETHANEDIOL, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER, ... | 著者 | Owen, C.D, Miura, T, Malla, T, Lukacik, L, Strain-Damerell, C.M, Tumber, A, Brewitz, L, McDonough, M.A, Salah, E, Terasaka, N, Katoh, T, Kawamura, A, Schofield, C.J, Suga, H, Walsh, M.A. | 登録日 | 2022-03-04 | 公開日 | 2023-03-22 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | In vitro selection of macrocyclic peptide inhibitors containing cyclic gamma 2,4 -amino acids targeting the SARS-CoV-2 main protease. Nat.Chem., 15, 2023
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1SFK
| Core (C) protein from West Nile Virus, subtype Kunjin | 分子名称: | CALCIUM ION, CHLORIDE ION, Core protein, ... | 著者 | Dokland, T, Walsh, M, Mackenzie, J.M, Khromykh, A.A, Ee, K.-H, Wang, S. | 登録日 | 2004-02-19 | 公開日 | 2004-08-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | West nile virus core protein; tetramer structure and ribbon formation Structure, 12, 2004
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1RZ0
| Flavin reductase PheA2 in native state | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, phenol 2-hydroxylase component B | 著者 | van den Heuvel, R.H, Westphal, A.H, Heck, A.J, Walsh, M.A, Rovida, S, van Berkel, W.J, Mattevi, A. | 登録日 | 2003-12-23 | 公開日 | 2004-04-06 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action. J.Biol.Chem., 279, 2004
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1RZ1
| Reduced flavin reductase PheA2 in complex with NAD | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, phenol 2-hydroxylase component B | 著者 | Van Den Heuvel, R.H, Westphal, A.H, Heck, A.J, Walsh, M.A, Rovida, S, Van Berkel, W.J, Mattevi, A. | 登録日 | 2003-12-23 | 公開日 | 2004-04-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action. J.Biol.Chem., 279, 2004
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6AC8
| Crystal structure of Mycobacterium smegmatis Mfd at 2.75 A resolution | 分子名称: | Mycobacterium smegmatis Mfd, SULFATE ION | 著者 | Putta, S, Fox, G.C, Walsh, M.A, Rao, D.N, Nagaraja, V, Natesh, R. | 登録日 | 2018-07-25 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural basis for nucleotide-mediated remodelling mechanism of Mycobacterium Mfd To Be Published
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8P1S
| Bifidobacterium asteroides alpha-L-fucosidase (TT1819) in complex with fucose. | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bifidobacterium asteroides alpha-L-fucosidase (TT1819), ... | 著者 | Owen, C.D, Penner, M, Gascuena, A.N, Wu, H, Hernando, P.J, Monaco, S, Le Gall, G, Gardner, R, Ndeh, D, Urbanowicz, P.A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N. | 登録日 | 2023-05-12 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Exploring sequence, structure and function of microbial fucosidases from glycoside hydrolase GH29 family To Be Published
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2VGZ
| CRYSTAL STRUCTURE OF HUMAN KYNURENINE AMINOTRANSFERASE II | 分子名称: | IODIDE ION, KYNURENINE/ALPHA-AMINOADIPATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Rossi, F, Garavaglia, S, Montalbano, V, Walsh, M.A, Rizzi, M. | 登録日 | 2007-11-16 | 公開日 | 2007-12-04 | 最終更新日 | 2015-12-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Human Kynurenine Aminotransferase II, a Drug Target for the Treatment of Schizophrenia. J.Biol.Chem., 283, 2008
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6AC6
| Ab initio crystal structure of Selenomethionine labelled Mycobacterium smegmatis Mfd | 分子名称: | Mycobacterium smegmatis Mfd, SULFATE ION | 著者 | Putta, S, Fox, G.C, Walsh, M.A, Rao, D.N, Nagaraja, V, Natesh, R. | 登録日 | 2018-07-25 | 公開日 | 2019-08-28 | 実験手法 | X-RAY DIFFRACTION (2.989 Å) | 主引用文献 | Structural basis for nucleotide-mediated remodelling mechanism of Mycobacterium Mfd To Be Published
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6ACA
| Crystal structure of Mycobacterium tuberculosis Mfd at 3.6 A resolution | 分子名称: | Mycobacterium tuberculosis Mfd | 著者 | Putta, S, Fox, G.C, Walsh, M.A, Rao, D.N, Nagaraja, V, Natesh, R. | 登録日 | 2018-07-26 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for nucleotide-mediated remodelling mechanism of Mycobacterium Mfd To Be Published
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6ACX
| Crystal structure of Mycobacterium smegmatis Mfd in complex with ADP + Pi at 3.5 A resolution. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Mycobacterium smegmatis Mfd, PHOSPHATE ION, ... | 著者 | Putta, S, Fox, G.C, Walsh, M.A, Rao, D.N, Nagaraja, V, Natesh, R. | 登録日 | 2018-07-27 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis for nucleotide-mediated remodelling mechanism of Mycobacterium Mfd To Be Published
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8B2T
| SARS-CoV-2 Main Protease (Mpro) in complex with nirmatrelvir alkyne | 分子名称: | 3C-like proteinase nsp5, Nirmatrelvir (reacted form) | 著者 | Owen, C.D, Crawshaw, A.D, Warren, A.J, Trincao, J, Zhao, Y, Brewitz, L, Malla, T.R, Salah, E, Petra, L, Strain-Damerell, C, Schofield, C.J, Walsh, M.A. | 登録日 | 2022-09-14 | 公開日 | 2023-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.893 Å) | 主引用文献 | Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. J.Med.Chem., 66, 2023
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