7Z4S

Crystal structure of SARS-CoV-2 Mpro in complex with cyclic peptide GM4 including unnatural amino acids.

Summary for 7Z4S

Entry DOI	10.2210/pdb7z4s/pdb
Descriptor	3C-like proteinase nsp5, Macrocyclic peptide inhibitor, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
Functional Keywords	protease, unknown function
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	4
Total formula weight	71373.41
Authors	Owen, C.D.,Miura, T.,Malla, T.,Lukacik, L.,Strain-Damerell, C.M.,Tumber, A.,Brewitz, L.,McDonough, M.A.,Salah, E.,Terasaka, N.,Katoh, T.,Kawamura, A.,Schofield, C.J.,Suga, H.,Walsh, M.A. (deposition date: 2022-03-04, release date: 2023-03-22, Last modification date: 2024-02-07)
Primary citation	Miura, T.,Malla, T.R.,Owen, C.D.,Tumber, A.,Brewitz, L.,McDonough, M.A.,Salah, E.,Terasaka, N.,Katoh, T.,Lukacik, P.,Strain-Damerell, C.,Mikolajek, H.,Walsh, M.A.,Kawamura, A.,Schofield, C.J.,Suga, H. In vitro selection of macrocyclic peptide inhibitors containing cyclic gamma 2,4 -amino acids targeting the SARS-CoV-2 main protease. Nat.Chem., 15:998-1005, 2023 Cited by PubMed: 37217786 DOI: 10.1038/s41557-023-01205-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation