2BE5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2be5 by Molmil](/molmil-images/mine/2be5) | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | Authors: | Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-10-22 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
|
|
2E3O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2e3o by Molmil](/molmil-images/mine/2e3o) | Crystal structure of CERT START domain in complex with C16-ceramide (P212121) | Descriptor: | DIMETHYL SULFOXIDE, Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE | Authors: | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | Deposit date: | 2006-11-28 | Release date: | 2007-12-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
2EFE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2efe by Molmil](/molmil-images/mine/2efe) | Ara7-GDPNH2/AtVps9a | Descriptor: | AMINOPHOSPHONIC ACID-GUANYLATE ESTER, Similarity to vacuolar protein sorting-associated protein VPS9, Small GTP-binding protein-like | Authors: | Ihara, K, Uejima, T, Wakatsuki, S. | Deposit date: | 2007-02-22 | Release date: | 2008-02-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5/Vps9 system J.Biol.Chem., 285, 2010
|
|
2F10
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f10 by Molmil](/molmil-images/mine/2f10) | Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor | Descriptor: | 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID, PHOSPHATE ION, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, McKimm-Breschkin, J, Colman, P.M, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-14 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor To be Published
|
|
2F13
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f13 by Molmil](/molmil-images/mine/2f13) | Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor | Descriptor: | (2R)-2,3-dihydroxypropyl 2-acetamido-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid, PHOSPHATE ION, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Mann, M.C, Thomson, R.J, Dyason, J.C, von Itzstein, M, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-14 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor To be Published
|
|
2D6L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d6l by Molmil](/molmil-images/mine/2d6l) | Crystal structure of mouse galectin-9 N-terminal CRD (crystal form 2) | Descriptor: | lectin, galactose binding, soluble 9 | Authors: | Nagae, M, Nishi, N, Nakamura, T, Wakatsuki, S, Kato, R. | Deposit date: | 2005-11-14 | Release date: | 2006-09-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the Galectin-9 N-terminal Carbohydrate Recognition Domain from Mus musculus Reveals the Basic Mechanism of Carbohydrate Recognition J.Biol.Chem., 281, 2006
|
|
2D6M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d6m by Molmil](/molmil-images/mine/2d6m) | Crystal structure of mouse galectin-9 N-terminal CRD in complex with lactose | Descriptor: | beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, lectin, galactose binding, ... | Authors: | Nagae, M, Nishi, N, Nakamura, T, Wakatsuki, S, Kato, R. | Deposit date: | 2005-11-14 | Release date: | 2006-09-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of the Galectin-9 N-terminal Carbohydrate Recognition Domain from Mus musculus Reveals the Basic Mechanism of Carbohydrate Recognition J.Biol.Chem., 281, 2006
|
|
2D6K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2d6k by Molmil](/molmil-images/mine/2d6k) | Crystal structure of mouse galectin-9 N-terminal CRD (crystal form 1) | Descriptor: | lectin, galactose binding, soluble 9 | Authors: | Nagae, M, Nishi, N, Nakamura, T, Murata, T, Wakatsuki, S, Kato, R. | Deposit date: | 2005-11-14 | Release date: | 2006-09-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the Galectin-9 N-terminal Carbohydrate Recognition Domain from Mus musculus Reveals the Basic Mechanism of Carbohydrate Recognition J.Biol.Chem., 281, 2006
|
|
2F11
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f11 by Molmil](/molmil-images/mine/2f11) | Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor | Descriptor: | 2-methylpropyl 2-acetamido-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid, PHOSPHATE ION, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Mann, M.C, Thomson, R.J, Dyason, J.C, von Itzstein, M, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-14 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor To be Published
|
|
2DUQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2duq by Molmil](/molmil-images/mine/2duq) | Crystal structure of VIP36 exoplasmic/lumenal domain, Ca2+/Man-bound form | Descriptor: | CALCIUM ION, CHLORIDE ION, Vesicular integral-membrane protein VIP36, ... | Authors: | Satoh, T, Cowieson, N.P, Kato, R, Wakatsuki, S. | Deposit date: | 2006-07-25 | Release date: | 2007-07-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36 J.Biol.Chem., 282, 2007
|
|
2DUR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2dur by Molmil](/molmil-images/mine/2dur) | Crystal structure of VIP36 exoplasmic/lumenal domain, Ca2+/Man2-bound form | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Satoh, T, Cowieson, N.P, Kato, R, Wakatsuki, S. | Deposit date: | 2006-07-25 | Release date: | 2007-07-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36 J.Biol.Chem., 282, 2007
|
|
2DUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2dup by Molmil](/molmil-images/mine/2dup) | Crystal structure of VIP36 exoplasmic/lumenal domain, metal-free form | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Satoh, T, Cowieson, N.P, Kato, R, Wakatsuki, S. | Deposit date: | 2006-07-25 | Release date: | 2007-07-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36 J.Biol.Chem., 282, 2007
|
|
2F26
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f26 by Molmil](/molmil-images/mine/2f26) | Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant | Descriptor: | CHLORIDE ION, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-15 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant To be Published
|
|
2F0Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f0z by Molmil](/molmil-images/mine/2f0z) | Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor | Descriptor: | Sialidase 2, ZANAMIVIR | Authors: | Chavas, L.M.G, Kato, R, McKimm-Breschkin, J, Colman, P.M, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-14 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor To be Published
|
|
2F25
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f25 by Molmil](/molmil-images/mine/2f25) | Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-15 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor To be Published
|
|
2E3Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2e3q by Molmil](/molmil-images/mine/2e3q) | Crystal structure of CERT START domain in complex with C18-ceramide (P212121) | Descriptor: | DIMETHYL SULFOXIDE, Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE | Authors: | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | Deposit date: | 2006-11-28 | Release date: | 2007-12-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
2EAD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ead by Molmil](/molmil-images/mine/2ead) | Crystal structure of 1,2-a-L-fucosidase from Bifidobacterium bifidum in complex with substrate | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Alpha-fucosidase, CALCIUM ION, ... | Authors: | Nagae, M, Tsuchiya, A, Katayama, T, Yamamoto, K, Wakatsuki, S, Kato, R. | Deposit date: | 2007-01-31 | Release date: | 2007-04-24 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural basis on the catalytic reaction mechanism of novel 1,2-alpha-L-fucosidase (AFCA) from Bifidobacterium bifidum J.Biol.Chem., 282, 2007
|
|
2EFC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2efc by Molmil](/molmil-images/mine/2efc) | Ara7-GDP/AtVps9a | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Similarity to vacuolar protein sorting-associated protein VPS9, Small GTP-binding protein-like | Authors: | Uejima, T, Ihara, K, Goh, T, Ito, E, Sunada, M, Ueda, T, Nakano, A, Wakatsuki, S. | Deposit date: | 2007-02-22 | Release date: | 2008-02-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5/Vps9 system J.Biol.Chem., 285, 2010
|
|
2E3P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2e3p by Molmil](/molmil-images/mine/2e3p) | Crystal structure of CERT START domain in complex with C16-cearmide (P1) | Descriptor: | Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE | Authors: | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | Deposit date: | 2006-11-28 | Release date: | 2007-12-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
2F24
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f24 by Molmil](/molmil-images/mine/2f24) | Crystal Structure of the Human Sialidase Neu2 E111Q Mutant | Descriptor: | CHLORIDE ION, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-15 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 E111Q Mutant To be Published
|
|
2F29
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f29 by Molmil](/molmil-images/mine/2f29) | Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-15 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.921 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor To be Published
|
|
2F12
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f12 by Molmil](/molmil-images/mine/2f12) | Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor | Descriptor: | 3-hydroxypropyl 2-acetamido-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid, PHOSPHATE ION, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Mann, M.C, Thomson, R.J, Dyason, J.C, von Itzstein, M, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-14 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor To be Published
|
|
2F28
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f28 by Molmil](/molmil-images/mine/2f28) | Crystal Structure of the Human Sialidase Neu2 Q116E Mutant | Descriptor: | CHLORIDE ION, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-15 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 Q116E Mutant To be Published
|
|
2F27
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f27 by Molmil](/molmil-images/mine/2f27) | Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Sialidase 2 | Authors: | Chavas, L.M.G, Kato, R, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S. | Deposit date: | 2005-11-15 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor To be Published
|
|