5U4X
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![BU of 5u4x by Molmil](/molmil-images/mine/5u4x) | Coactivator-associated arginine methyltransferase 1 with TP-064 | Descriptor: | Histone-arginine methyltransferase CARM1, N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | DONG, A, ZENG, H, Saikatendu, K.S, STONE, H, WALKER, J.R, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2016-12-06 | Release date: | 2016-12-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget, 9, 2018
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2O0L
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![BU of 2o0l by Molmil](/molmil-images/mine/2o0l) | Human spermidine synthase | Descriptor: | 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, Spermidine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-27 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
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4RWS
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![BU of 4rws by Molmil](/molmil-images/mine/4rws) | Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) | Descriptor: | C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 | Authors: | Qin, L, Kufareva, I, Holden, L, Wang, C, Zheng, Y, Wu, H, Fenalti, G, Han, G.W, Cherezov, V, Abagyan, R, Stevens, R.C, Handel, T.M, GPCR Network (GPCR) | Deposit date: | 2014-12-05 | Release date: | 2015-02-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science, 347, 2015
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6BZE
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![BU of 6bze by Molmil](/molmil-images/mine/6bze) | Cryo-EM structure of BCL10 CARD filament | Descriptor: | B-cell lymphoma/leukemia 10 | Authors: | David, L, Li, Y, Ma, J, Garner, E, Zhang, X, Wu, H. | Deposit date: | 2017-12-23 | Release date: | 2018-02-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4H12
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![BU of 4h12 by Molmil](/molmil-images/mine/4h12) | The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine | Descriptor: | CHLORIDE ION, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Amaya, M.F, Dong, A, Zeng, H, Mackenzie, F, Bunnage, M, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-09-10 | Release date: | 2012-10-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134, 2012
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2OB0
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![BU of 2ob0 by Molmil](/molmil-images/mine/2ob0) | Human MAK3 homolog in complex with Acetyl-CoA | Descriptor: | ACETYL COENZYME *A, Human MAK3 homolog | Authors: | Walker, J.R, Schuetz, S, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-18 | Release date: | 2006-12-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of Human MAK3 homolog To be Published
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2GIV
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![BU of 2giv by Molmil](/molmil-images/mine/2giv) | Human MYST histone acetyltransferase 1 | Descriptor: | ACETYL COENZYME *A, CHLORIDE ION, Probable histone acetyltransferase MYST1, ... | Authors: | Min, J, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-03-29 | Release date: | 2006-04-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | The Crystal Structure of Human MYST histone acetyltransferase 1 in complex with acetylcoenzyme A To be Published
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4HAE
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![BU of 4hae by Molmil](/molmil-images/mine/4hae) | Crystal structure of the CDYL2-chromodomain | Descriptor: | Chromodomain Y-like protein 2, SULFATE ION, UNKNOWN ATOM OR ION | Authors: | Qin, S, Dombrovski, L, Tempel, W, Dong, A, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-09-26 | Release date: | 2012-10-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the CDYL2-chromodomain To be Published
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2OZU
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![BU of 2ozu by Molmil](/molmil-images/mine/2ozu) | Crystal structure of human MYST histone acetyltransferase 3 in complex with acetylcoenzyme A | Descriptor: | ACETAMIDE, ACETYL COENZYME *A, Histone acetyltransferase MYST3, ... | Authors: | Min, J, Wu, H, Dombrovski, L, Bernstein, G, Dong, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-02-27 | Release date: | 2007-03-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structure of human MYST histone acetyltransferase 3 in complex with acetylcoenzyme A To be Published
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2PQT
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![BU of 2pqt by Molmil](/molmil-images/mine/2pqt) | Human N-acetyltransferase 1 | Descriptor: | Arylamine N-acetyltransferase 1, CHLORIDE ION, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-05-02 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural Basis of Substrate-binding Specificity of Human Arylamine N-Acetyltransferases. J.Biol.Chem., 282, 2007
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2PSW
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![BU of 2psw by Molmil](/molmil-images/mine/2psw) | Human MAK3 homolog in complex with CoA | Descriptor: | COENZYME A, N-acetyltransferase 13 | Authors: | Walker, J.R, Schuetz, A, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-05-07 | Release date: | 2007-06-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of Human MAK3 homolog. To be Published
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2PQ8
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![BU of 2pq8 by Molmil](/molmil-images/mine/2pq8) | MYST histone acetyltransferase 1 | Descriptor: | COENZYME A, Probable histone acetyltransferase MYST1, UNKNOWN ATOM OR ION, ... | Authors: | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-05-01 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | MYST histone acetyltransferase 1. To be Published
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2PFR
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![BU of 2pfr by Molmil](/molmil-images/mine/2pfr) | Human N-acetyltransferase 2 | Descriptor: | Arylamine N-acetyltransferase 2, COENZYME A, SULFATE ION, ... | Authors: | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-04-05 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | The Crystal Structure of Human N-acetyltransferase 2 in complex with CoA to be published
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3KNV
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![BU of 3knv by Molmil](/molmil-images/mine/3knv) | |
2O05
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![BU of 2o05 by Molmil](/molmil-images/mine/2o05) | Human spermidine synthase | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, Spermidine synthase | Authors: | Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-27 | Release date: | 2006-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
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2P5X
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![BU of 2p5x by Molmil](/molmil-images/mine/2p5x) | Crystal structure of Maf domain of human N-acetylserotonin O-methyltransferase-like protein | Descriptor: | N-acetylserotonin O-methyltransferase-like protein, PHOSPHATE ION | Authors: | Min, J, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-03-16 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem.Biol., 20, 2013
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2GTR
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![BU of 2gtr by Molmil](/molmil-images/mine/2gtr) | Human chromodomain Y-like protein | Descriptor: | Chromodomain Y-like protein | Authors: | Min, J, Wu, H, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-04-28 | Release date: | 2006-05-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Crystal Structure of Human chromodomain Y-like Protein. To be Published
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4IA9
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![BU of 4ia9 by Molmil](/molmil-images/mine/4ia9) | Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide | Descriptor: | 1,2-ETHANEDIOL, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... | Authors: | Dong, A, Dombrovski, L, Bolshan, Y, Getlik, M, Tempel, W, Kuznetsova, E, Wasney, G.A, Hajian, T, Poda, G, Nguyen, K.T, Schapira, M, Brown, P.J, Al-awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Smil, D, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-06 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett, 4, 2013
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7EJ4
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![BU of 7ej4 by Molmil](/molmil-images/mine/7ej4) | Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RBD-chAb-25, ... | Authors: | Yang, T.J, Yu, P.Y, Wu, H.C, Hsu, S.T.D. | Deposit date: | 2021-04-01 | Release date: | 2021-06-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-25 To be published
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7EJ5
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![BU of 7ej5 by Molmil](/molmil-images/mine/7ej5) | Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-45 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RBD-chAb45, ... | Authors: | Yang, T.J, Yu, P.Y, Wu, H.C, Hsu, S.T.D. | Deposit date: | 2021-04-01 | Release date: | 2021-06-23 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of SARS-CoV-2 spike in complex with a neutralizing antibody RBD-chAb-45 To Be Published
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4MI0
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![BU of 4mi0 by Molmil](/molmil-images/mine/4mi0) | Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) | Descriptor: | Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION | Authors: | Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2013-08-30 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
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5TEY
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![BU of 5tey by Molmil](/molmil-images/mine/5tey) | Human METTL3-METTL14 complex | Descriptor: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ... | Authors: | DONG, A, ZENG, H, LI, Y, TEMPEL, W, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2016-09-23 | Release date: | 2016-11-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Human METTL3-METTL14 complex to be published
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5TTF
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![BU of 5ttf by Molmil](/molmil-images/mine/5ttf) | Crystal structure of catalytic domain of G9a with MS012 | Descriptor: | CHLORIDE ION, Histone-lysine N-methyltransferase EHMT2, N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine, ... | Authors: | DONG, A, ZENG, H, LIU, J, XIONG, Y, BABAULT, N, JIN, J, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, WU, H, BROWN, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2016-11-03 | Release date: | 2016-12-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J. Med. Chem., 60, 2017
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2MA1
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![BU of 2ma1 by Molmil](/molmil-images/mine/2ma1) | Solution structure of HRDC1 domain of RecQ helicase from Deinococcus radiodurans | Descriptor: | DNA helicase RecQ | Authors: | Liu, S, Zhang, W, Gao, Z, Ming, Q, Hou, H, Lan, W, Wu, H, Cao, C, Dong, Y. | Deposit date: | 2013-06-24 | Release date: | 2013-07-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans To be Published
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4L5S
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![BU of 4l5s by Molmil](/molmil-images/mine/4l5s) | p202 HIN1 in complex with 12-mer dsDNA | Descriptor: | 12-mer DNA, Interferon-activable protein 202, SULFATE ION | Authors: | Yin, Q, Tian, Y, Wu, H. | Deposit date: | 2013-06-11 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Rep, 4, 2013
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