7E4R
 
 | | Crystal structure of tubulin in complex with D-DM1-SMe | | Descriptor: | (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl)propanoyl)-D-alaninate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Li, W. | | Deposit date: | 2021-02-15 | | Release date: | 2021-07-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.597 Å) | | Cite: | C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.
Biochem.Biophys.Res.Commun., 566, 2021
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2JOW
 | | Differences in the electrostatic surfaces of the type III secretion needle proteins | | Descriptor: | Protein prgI | | Authors: | Wang, Y, Ouellette, A.N, Egan, C.W, De Guzman, R.N. | | Deposit date: | 2007-04-06 | | Release date: | 2007-07-24 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Differences in the Electrostatic Surfaces of the Type III Secretion Needle Proteins PrgI, BsaL, and MxiH
J.Mol.Biol., 371, 2007
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7EN3
 | | Crystal structure of tubulin in complex with Tubulysin analogue TGL | | Descriptor: | (2S,4R)-5-(4-fluorophenyl)-2-methyl-4-[[2-[(1R,3R)-4-methyl-3-[5-methylhexyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-1-oxidanyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Li, W. | | Deposit date: | 2021-04-15 | | Release date: | 2022-04-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.643 Å) | | Cite: | The X-ray structure of tubulysin analogue TGL in complex with tubulin and three possible routes for the development of next-generation tubulysin analogues.
Biochem.Biophys.Res.Commun., 565, 2021
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7E4P
 | | Crystal structure of tubulin in complex with Ansamitocin P3 | | Descriptor: | (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Li, W. | | Deposit date: | 2021-02-14 | | Release date: | 2022-02-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids
To Be Published
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7E4Y
 | | Crystal structure of tubulin in complex with L-DM4-SMe | | Descriptor: | (1S,2S,3S,5R,6S,16E,18E,20S,21R)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-methyl-3-(methyldisulfanyl)butanoyl]amino}propanoate (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Li, W. | | Deposit date: | 2021-02-16 | | Release date: | 2022-02-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.708 Å) | | Cite: | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids
To Be Published
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2IVH
 | | Crystal structure of the nuclease domain of ColE7 (H545Q mutant) in complex with an 18-bp duplex DNA | | Descriptor: | 5'-D(*GP*GP*AP*AP*TP*TP*CP*GP*AP*TP *CP*GP*AP*AP*TP*TP*CP*C)-3', COLCIN-E7, ZINC ION | | Authors: | Wang, Y.T, Yang, W.J, Li, C.L, Doudeva, L.G, Yuan, H.S. | | Deposit date: | 2006-06-13 | | Release date: | 2007-01-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for Sequence-Dependent DNA Cleavage by Nonspecific Endonucleases.
Nucleic Acids Res., 35, 2007
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2IVK
 | | Crystal structure of the periplasmic endonuclease Vvn complexed with a 16-bp DNA | | Descriptor: | 5'-D(*AP*AP*TP*TP*CP*GP*AP*TP*CP*GP *AP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*TP*CP*GP*AP*TP*CP *GP*AP*AP*TP*T)-3', 5'-D(*GP*AP*AP*TP*TP*CP*GP*AP*TP*CP *GP*AP*AP*TP*TP*C)-3', ... | | Authors: | Wang, Y.T, Yang, W.J, Li, C.L, Doudeva, L.G, Yuan, H.S. | | Deposit date: | 2006-06-14 | | Release date: | 2007-01-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Sequence-Dependent DNA Cleavage by Nonspecific Endonucleases.
Nucleic Acids Res., 35, 2007
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2IL3
 | | Structures of an Insect Epsilon-class Glutathione S-transferase from the Malaria Vector Anopheles Gambiae: Evidence for High DDT-detoxifying Activity | | Descriptor: | Epsilon-class Glutathione S-transferase | | Authors: | Wang, Y, Hemingway, J, Ranson, H, Meehan, E.J, Chen, L. | | Deposit date: | 2006-10-02 | | Release date: | 2007-10-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
J.Struct.Biol., 164, 2008
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2IMK
 | | Structures of an Insect Epsilon-class Glutathione S-transferase from the Malaria Vector Anopheles Gambiae: Evidence for High DDT-detoxifying Activity | | Descriptor: | Epsilon-class Glutathione S-transferase, S-HEXYLGLUTATHIONE | | Authors: | Wang, Y, Hemingway, J, Ranson, H, Meehan, E.J, Chen, L. | | Deposit date: | 2006-10-02 | | Release date: | 2007-10-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity
J.Struct.Biol., 164, 2008
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2K48
 | | NMR Structure of the N-terminal Coiled Coil Domain of the Andes Hantavirus Nucleocapsid Protein | | Descriptor: | Nucleoprotein | | Authors: | Wang, Y, Boudreaux, D.M, Estrada, D.F, Egan, C.W, St Jeor, S.C, De Guzman, R.N. | | Deposit date: | 2008-05-30 | | Release date: | 2008-08-05 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | NMR Structure of the N-terminal Coiled Coil Domain of the Andes Hantavirus Nucleocapsid Protein.
J.Biol.Chem., 283, 2008
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2M5I
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2KKT
 | | Solution structure of the SCA7 domain of human Ataxin-7-L3 protein | | Descriptor: | Ataxin-7-like protein 3, ZINC ION | | Authors: | Wang, Y, Atkinson, A.R, Bonnet, J, Romier, C, Kieffer, B. | | Deposit date: | 2009-06-29 | | Release date: | 2010-06-16 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Histone deubiquitination by SAGA is modulated by an atypical zinc finger domain of Ataxin-7
To be Published
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7EF1
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7EEZ
 | | crystal structure of maize SHH2 SAWADEE domain | | Descriptor: | HB transcription factor, ZINC ION | | Authors: | Wang, Y, Du, J. | | Deposit date: | 2021-03-20 | | Release date: | 2021-06-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.902 Å) | | Cite: | Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.
J Integr Plant Biol, 63, 2021
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7EF2
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7EF3
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7EF0
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7DAD
 | | EPD in complex with tubulin | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Wang, Y, Wu, C. | | Deposit date: | 2020-10-16 | | Release date: | 2021-03-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.
Biochem.Biophys.Res.Commun., 534, 2021
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7ENR
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7ENI
 | | Crystal structure of cas and anti-cas protein complex | | Descriptor: | AcrIIA13 protein, CRISPR-associated endonuclease Cas9, PHOSPHATE ION, ... | | Authors: | Wang, Y, Li, X. | | Deposit date: | 2021-04-17 | | Release date: | 2022-04-20 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.632 Å) | | Cite: | Crystal structure of cas and anti-cas protein complex
To Be Published
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7ENH
 | | Crystal structure of cas and anti-cas protein complex | | Descriptor: | AcrIIA14 protein, CRISPR-associated endonuclease Cas9, NICKEL (II) ION | | Authors: | Wang, Y, Li, X. | | Deposit date: | 2021-04-17 | | Release date: | 2022-04-20 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Crystal structure of cas and anti-cas protein complex
To Be Published
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7ENM
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2KKR
 | | Solution structure of SCA7 zinc finger domain from human ataxin-7 protein | | Descriptor: | Ataxin-7, ZINC ION | | Authors: | Wang, Y, Atkinson, A.R, Bonnet, J, Romier, C, Kieffer, B, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2009-06-29 | | Release date: | 2010-06-09 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Histone deubiquitination by SAGA is modulated by an atypical zinc finger domain of Ataxin-7
To be Published
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7DMZ
 | | GMPCPP microtubule complex | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Wang, Y.X. | | Deposit date: | 2020-12-08 | | Release date: | 2021-12-08 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | GMPCPP microtubule complex
To Be Published
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7DN0
 | | AJ-GMPCPP-MT-non-seam | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Wang, Y.X. | | Deposit date: | 2020-12-08 | | Release date: | 2021-12-08 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | GMPCPP microtubule
To Be Published
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