1HW4
| STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, THYMIDYLATE SYNTHASE | Authors: | Phan, J, Steadman, J.D, Koli, S, Ding, W.C, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L. | Deposit date: | 2001-01-09 | Release date: | 2001-01-24 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. J.Biol.Chem., 276, 2001
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3RRJ
| Crystal structure of tm0922, a fusion of a domain of unknown function and ADP/ATP-dependent NAD(P)H-hydrate dehydratase from Thermotoga maritima in complex with P1,P5-Di(adenosine-5') pentaphosphate | Descriptor: | BIS(ADENOSINE)-5'-PENTAPHOSPHATE, Bifunctional NAD(P)H-hydrate repair enzyme Nnr, GLYCEROL, ... | Authors: | Shumilin, I.A, Cymborowski, M, Lesley, S.A, Minor, W. | Deposit date: | 2011-04-29 | Release date: | 2011-07-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification of unknown protein function using metabolite cocktail screening. Structure, 20, 2012
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1HQK
| CRYSTAL STRUCTURE ANALYSIS OF LUMAZINE SYNTHASE FROM AQUIFEX AEOLICUS | Descriptor: | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE | Authors: | Zhang, X, Meining, W, Fischer, M, Bacher, A, Ladenstein, R. | Deposit date: | 2000-12-18 | Release date: | 2001-12-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons. J.Mol.Biol., 306, 2001
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2POC
| The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from Candida albicans | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, ACETATE ION, SODIUM ION, ... | Authors: | Raczynska, J, Olchowy, J, Milewski, S, Rypniewski, W. | Deposit date: | 2007-04-26 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal and Solution Studies of Glucosamine-6-phosphate Synthase from Candida albicans J.Mol.Biol., 372, 2007
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3N99
| Crystal structure of TM1086 | Descriptor: | CHLORIDE ION, uncharacterized protein TM1086 | Authors: | Chruszcz, M, Domagalski, M.J, Wang, S, Evdokimova, E, Kudritska, M, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-05-28 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal structure of TM1086 To be Published
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1HYV
| HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM | Descriptor: | CHLORIDE ION, INTEGRASE, SULFATE ION, ... | Authors: | Molteni, V, Greenwald, J, Rhodes, D, Hwang, Y, Kwiatkowski, W, Bushman, F.D, Siegel, J.S, Choe, S. | Deposit date: | 2001-01-22 | Release date: | 2001-04-04 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain. Acta Crystallogr.,Sect.D, 57, 2001
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2PT9
| The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine and the inhibitor cis-4-methylcyclohexylamine (4MCHA) | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, GLYCEROL, ... | Authors: | Dufe, V.T, Qiu, W, Muller, I.B, Hui, R, Walter, R.D, Al-Karadaghi, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-05-08 | Release date: | 2008-04-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J.Mol.Biol., 373, 2007
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1HYZ
| HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM. | Descriptor: | (3,4-DIHYDROXY-PHENYL)-TRIPHENYL-ARSONIUM, CHLORIDE ION, INTEGRASE, ... | Authors: | Molteni, V, Greenwald, J, Rhodes, D, Hwang, Y, Kwiatkowski, W, Bushman, F.D, Siegel, J.S, Choe, S. | Deposit date: | 2001-01-22 | Release date: | 2001-04-04 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain. Acta Crystallogr.,Sect.D, 57, 2001
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3NGO
| Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA | Descriptor: | 5'-D(*AP*AP*AP*A)-3', CCR4-NOT transcription complex subunit 6-like, MAGNESIUM ION | Authors: | Wang, H, Morita, M, Yang, W, Bartlam, M, Yamamoto, T, Rao, Z. | Deposit date: | 2010-06-12 | Release date: | 2010-07-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. Embo J., 2010
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1OH2
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1OPK
| Structural basis for the auto-inhibition of c-Abl tyrosine kinase | Descriptor: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... | Authors: | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | Deposit date: | 2003-03-06 | Release date: | 2003-04-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
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3ROX
| Crystal Structure of Mouse Apolipoprotein A-I Binding Protein in Complex with Theophylline | Descriptor: | Apolipoprotein A-I-binding protein, SULFATE ION, THEOPHYLLINE | Authors: | Shumilin, I.A, Jha, K.N, Cymborowski, M, Herr, J.C, Minor, W. | Deposit date: | 2011-04-26 | Release date: | 2012-07-18 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Identification of unknown protein function using metabolite cocktail screening. Structure, 20, 2012
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3RQ5
| Crystal Structure of ADP/ATP-dependent NAD(P)H-hydrate dehydratase from Bacillus subtilis co-crystallized with ATP/Mg2+ and soaked with CoA | Descriptor: | ADP/ATP-dependent NAD(P)H-hydrate dehydratase, COENZYME A, GLYCEROL | Authors: | Shumilin, I.A, Cymborowski, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-04-27 | Release date: | 2011-07-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Identification of unknown protein function using metabolite cocktail screening. Structure, 20, 2012
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3RQH
| Crystal Structure of ADP/ATP-dependent NAD(P)H-hydrate dehydratase from Bacillus subtilis in complex with P1,P6-Di(adenosine-5') hexaphosphate | Descriptor: | ADP/ATP-DEPENDENT NAD(P)H-HYDRATE DEHYDRATASE, MAGNESIUM ION, P1,P6-Di(adenosine-5') hexaphosphate | Authors: | Shumilin, I.A, Cymborowski, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-04-28 | Release date: | 2011-07-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Identification of unknown protein function using metabolite cocktail screening. Structure, 20, 2012
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3RQR
| Crystal structure of the RYR domain of the rabbit ryanodine receptor | Descriptor: | (UNK)(UNK)(UNK)(UNK), Ryanodine receptor 1 | Authors: | Nair, U.B, Li, W, Dong, A, Walker, J.R, Gramolini, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2011-04-28 | Release date: | 2011-06-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structural determination of the phosphorylation domain of the ryanodine receptor. Febs J., 279, 2012
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1HJD
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2PXX
| Human putative methyltransferase MGC2408 | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION, Uncharacterized protein MGC2408 | Authors: | Tempel, W, Wu, H, Dombrovsky, L, Zeng, H, Zhu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-05-14 | Release date: | 2007-05-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene. Proteins, 74, 2009
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3R90
| Crystal structure of Malignant T cell-amplified sequence 1 protein | Descriptor: | GLYCEROL, Malignant T cell-amplified sequence 1, SULFATE ION, ... | Authors: | Hong, B, Dimov, S, Tempel, W, Tong, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-03-24 | Release date: | 2011-04-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of Malignant T cell-amplified sequence 1 protein to be published
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1NN7
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3RAO
| Crystal Structure of the Luciferase-like Monooxygenase from Bacillus cereus ATCC 10987. | Descriptor: | Putative Luciferase-like Monooxygenase, SULFATE ION | Authors: | Domagalski, M.J, Chruszcz, M, Xu, X, Cui, H, Chin, S, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-03-28 | Release date: | 2011-05-11 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Luciferase-like Monooxygenase from Bacillus cereus ATCC 10987. To be Published
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2PYP
| PHOTOACTIVE YELLOW PROTEIN, PHOTOSTATIONARY STATE, 50% GROUND STATE, 50% BLEACHED | Descriptor: | 4'-HYDROXYCINNAMIC ACID, PHOTOACTIVE YELLOW PROTEIN | Authors: | Genick, U.K, Borgstahl, G.E.O, Ng, K, Ren, Z, Pradervand, C, Burke, P, Srajer, V, Teng, T, Schildkamp, W, Mcree, D.E, Moffat, K, Getzoff, E.D. | Deposit date: | 1997-02-03 | Release date: | 1998-04-29 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of a protein photocycle intermediate by millisecond time-resolved crystallography. Science, 275, 1997
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3NKU
| Crystal structure of the N-terminal domain of DrrA/SidM from Legionella pneumophila | Descriptor: | DI(HYDROXYETHYL)ETHER, DrrA, TRIETHYLENE GLYCOL | Authors: | Mueller, M.P, Peters, H, Blankenfeldt, W, Goody, R.S, Itzen, A. | Deposit date: | 2010-06-21 | Release date: | 2010-08-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science, 329, 2010
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1F07
| STRUCTURE OF COENZYME F420 DEPENDENT TETRAHYDROMETHANOPTERIN REDUCTASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | Authors: | Shima, S, Warkentin, E, Grabarse, W, Thauer, R.K, Ermler, U. | Deposit date: | 2000-05-15 | Release date: | 2000-09-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of coenzyme F(420) dependent methylenetetrahydromethanopterin reductase from two methanogenic archaea. J.Mol.Biol., 300, 2000
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1NNX
| Structure of the hypothetical protein ygiW from E. coli. | Descriptor: | Protein ygiW, SULFATE ION | Authors: | Lehmann, C, Galkin, A, Pullalarevu, S, Sarikaya, E, Krajewski, W, Lim, K, Howard, A, Herzberg, O, Structure 2 Function Project (S2F) | Deposit date: | 2003-01-14 | Release date: | 2004-03-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of the hypothetical protein ygiW from E. coli. To be Published
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3RSY
| Cellobiose phosphorylase from Cellulomonas uda in complex with sulfate and glycerol | Descriptor: | Cellobiose phosphorylase, GLYCEROL, SULFATE ION | Authors: | Van Hoorebeke, A, Stout, J, Soetaert, W, Van Beeumen, J, Desmet, T, Savvides, S. | Deposit date: | 2011-05-02 | Release date: | 2012-06-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Cellobiose phosphorylase: reconstructing the structural itinerary along the catalytic pathway To be Published
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