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PDB: 12889 件
7MNA
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BU of 7mna by Molmil
PTP1B 1-284 F225Y-R199N in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNC
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BU of 7mnc by Molmil
PTP1B L204A
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MND
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BU of 7mnd by Molmil
PTP1B L204A in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNF
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BU of 7mnf by Molmil
PTP1B P206G in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNE
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BU of 7mne by Molmil
PTP1B P206G mutation, open state
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MNB
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BU of 7mnb by Molmil
PTP1B F225Y-R199N-L195R in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, GLYCEROL, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-30
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MOU
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BU of 7mou by Molmil
PTP1B F225Y-R199N-L195R
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-05-03
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MOW
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BU of 7mow by Molmil
PTP1B F225I in complex with TCS401
分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-05-03
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MOV
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BU of 7mov by Molmil
PTP1B 1-301 F225Y-R199N mutations
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-05-03
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MKZ
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BU of 7mkz by Molmil
PTP1B F225Y mutant, open state
分子名称: CHLORIDE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
著者Torgeson, K.R, Page, R, Peti, W.
登録日2021-04-27
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
8AK5
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BU of 8ak5 by Molmil
Human Sirt6 in complex with ADP-ribose and fragment pyroglutamic acid
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AKB
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BU of 8akb by Molmil
Human Sirt6 in complex with ADP-ribose and fragment 4-nitrocatechol
分子名称: 1,2-ETHANEDIOL, 4-NITROCATECHOL, DI(HYDROXYETHYL)ETHER, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AKF
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BU of 8akf by Molmil
Human Sirt6 in complex with ADP-ribose and fragment 3-aminobenzamide
分子名称: 1,2-ETHANEDIOL, 3-aminobenzamide, CHLORIDE ION, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AK6
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BU of 8ak6 by Molmil
Human Sirt6 in complex with ADP-ribose and fragment sulfamethoxazole
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AK9
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BU of 8ak9 by Molmil
Human Sirt6 in complex with ADP-ribose and fragment Isatin
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AKD
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BU of 8akd by Molmil
Human Sirt6 in complex with ADP-ribose and fragment 1-methyl-L-histidine
分子名称: 4-METHYL-HISTIDINE, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AK7
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BU of 8ak7 by Molmil
Human Sirt6 in complex with ADP-ribose and fragment 6-O-methylguanine
分子名称: 1,2-ETHANEDIOL, 6-O-methylguanine, CHLORIDE ION, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AKC
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BU of 8akc by Molmil
Human Sirt6 in complex with ADP-ribose and fragment 3-(acetylamino)thiophene-2-carboxylic acid
分子名称: 3-(acetylamino)thiophene-2-carboxylic acid, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AKA
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BU of 8aka by Molmil
Human Sirt6 in complex with ADP-ribose and fragment cis-resveratrol
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AKE
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BU of 8ake by Molmil
Human Sirt6 in complex with ADP-ribose and fragment nicotinamide
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
1A0T
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BU of 1a0t by Molmil
SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES
分子名称: CALCIUM ION, SUCROSE-SPECIFIC PORIN, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose
著者Diederichs, K, Welte, W.
登録日1997-12-08
公開日1998-03-18
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose.
Nat.Struct.Biol., 5, 1998
8AK8
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BU of 8ak8 by Molmil
Human Sirt6 in complex with ADP-ribose and fragment 4-hydroxybenzamide
分子名称: 4-HYDROXYBENZAMIDE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
8AKG
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BU of 8akg by Molmil
Human Sirt6 in complex with ADP-ribose and fragment 4-amino-6-chlorobenzene-1,3-disulfonamide
分子名称: 1,2-ETHANEDIOL, 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, CHLORIDE ION, ...
著者You, W, Steegborn, C.
登録日2022-07-29
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
To Be Published
5WDH
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BU of 5wdh by Molmil
Motor domain of human kinesin family member C1
分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIFC1, MAGNESIUM ION, ...
著者Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC)
登録日2017-07-05
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.248 Å)
主引用文献Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
8AMC
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BU of 8amc by Molmil
Crystal Structure of cat allergen Fel d 4
分子名称: Allergen Fel d 4, SULFATE ION
著者Schooltink, L, Sagmeister, T, Gottstein, N, Pavkov-Keller, T, Keller, W.
登録日2022-08-03
公開日2023-08-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Crystal Structure of cat allergen Fel d 4
To Be Published

222036

件を2024-07-03に公開中

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