2QNW
| Toxoplasma gondii apicoplast-targeted acyl carrier protein | 分子名称: | Acyl carrier protein, SODIUM ION, SULFATE ION, ... | 著者 | Lunin, V.V, Wernimont, A, Lew, J, Qiu, W, Lin, L, Hassanali, A, Kozieradzki, I, Zhao, Y, Schapira, M, Bochkarev, A, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-19 | 公開日 | 2007-07-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Toxoplasma gondii apicoplast-targeted acyl carrier protein. To be Published
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7WTJ
| SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv286 | 分子名称: | Heavy chain of XGv286, Light chain of XGv286, Spike protein S1 | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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7WTF
| SARS-CoV-2 Omicron variant spike in complex with Fab XGv051 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of XGv051, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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2QXG
| Crystal Structure of Human Kallikrein 7 in Complex with Ala-Ala-Phe-chloromethylketone | 分子名称: | Kallikrein-7, L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide | 著者 | Debela, M, Hess, P, Magdolen, V, Bode, W, Steiner, T, Goettig, P. | 登録日 | 2007-08-11 | 公開日 | 2008-01-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7. Proc.Natl.Acad.Sci.Usa, 104, 2007
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7WTI
| SARS-CoV-2 Omicron variant spike in complex with Fab XGv264 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of XGv264, Light chain of XGv264, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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2QTC
| E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate | 分子名称: | 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, MAGNESIUM ION, Pyruvate dehydrogenase E1 component | 著者 | Furey, W, Arjunan, P, Chandrasekhar, K. | 登録日 | 2007-08-01 | 公開日 | 2007-08-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | A Dynamic Loop at the Active Center of the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Modulates Substrate Utilization and Chemical Communication with the E2 Component J.Biol.Chem., 282, 2007
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5E1D
| NTMT1 in complex with YPKRIA peptide | 分子名称: | GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ... | 著者 | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-09-29 | 公開日 | 2015-10-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural basis for substrate recognition by the human N-terminal methyltransferase 1. Genes Dev., 29, 2015
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5E1O
| Crystal structure of NTMT1 in complex with RPKRIA peptide | 分子名称: | GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ... | 著者 | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-09-29 | 公開日 | 2015-10-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for substrate recognition by the human N-terminal methyltransferase 1. Genes Dev., 29, 2015
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3T2E
| Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, F6P-bound form | 分子名称: | FRUCTOSE -6-PHOSPHATE, Fructose-1,6-bisphosphate aldolase/phosphatase, MAGNESIUM ION | 著者 | Du, J, Say, R, Lue, W, Fuchs, G, Einsle, O. | 登録日 | 2011-07-22 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Active-site remodelling in the bifunctional fructose-1,6-bisphosphate aldolase/phosphatase. Nature, 478, 2011
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5E26
| Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | 著者 | DONG, A, LOPPNAU, P, RAVICHANDRAN, M, CHENG, C, TEMPEL, W, SEITOVA, A, HUTCHINSON, A, HONG, B.S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2015-09-30 | 公開日 | 2015-10-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate to be published
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2R0R
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2QDL
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3T9I
| Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution | 分子名称: | 2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol, Proto-oncogene serine/threonine-protein kinase pim-1 | 著者 | Bellamacina, C, Shu, W, Le, V, Nishiguchi, G, Bussiere, D. | 登録日 | 2011-08-02 | 公開日 | 2011-10-12 | 最終更新日 | 2011-11-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg.Med.Chem.Lett., 21, 2011
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5EGN
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7P68
| Globular glial tauopathy type 3 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7OLX
| MerTK kinase domain with type 1.5 inhibitor containing a tri-methyl pyrazole group | 分子名称: | CHLORIDE ION, Tyrosine-protein kinase Mer, ~{N}-[[3-[4-[(dimethylamino)methyl]phenyl]imidazo[1,2-a]pyridin-6-yl]methyl]-~{N}-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine | 著者 | Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Winter-Holt, J. | 登録日 | 2021-05-20 | 公開日 | 2021-09-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Optimization of an Imidazo[1,2- a ]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy. J.Med.Chem., 64, 2021
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7P6D
| Argyrophilic grain disease type 1 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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5EPW
| C-Terminal Domain Of Human Coronavirus Nl63 Nucleocapsid Protein | 分子名称: | Nucleoprotein | 著者 | Szelazek, B, Kabala, W, Kus, K, Zdzalik, M, Golik, P, Florek, D, Burmistrz, M, Pyrc, K, Dubin, G. | 登録日 | 2015-11-12 | 公開日 | 2017-02-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Characterization of Human Coronavirus NL63 N Protein. J. Virol., 91, 2017
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7OLS
| MerTK kinase domain with type 1.5 inhibitor containing a di-methyl pyrazole group | 分子名称: | 5-[4-(1,5-dimethylpyrazol-4-yl)-2-methyl-phenyl]-~{N}-(imidazo[1,2-a]pyridin-6-ylmethyl)-~{N}-methyl-1,3,4-oxadiazol-2-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Winter-Holt, J. | 登録日 | 2021-05-20 | 公開日 | 2021-09-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Optimization of an Imidazo[1,2- a ]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy. J.Med.Chem., 64, 2021
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2R2Q
| Crystal structure of human Gamma-Aminobutyric Acid Receptor-Associated Protein-like 1 (GABARAP1), Isoform CRA_a | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Gamma-aminobutyric acid receptor-associated protein-like 1, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Paramanathan, R, Davis, T, Mujib, S, Butler-Cole, C, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-08-27 | 公開日 | 2007-09-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of human Gamma-Aminobutyric Acid Receptor-Associated Protein-like 1 (GABARAP1), Isoform CRA_a. To be Published
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5EQ0
| Crystal Structure of chromodomain of CBX8 in complex with inhibitor UNC3866 | 分子名称: | Chromobox protein homolog 8, UNKNOWN ATOM OR ION, unc3866 | 著者 | Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-11-12 | 公開日 | 2015-12-23 | 最終更新日 | 2019-11-27 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol., 12, 2016
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7P67
| Globular glial tauopathy type 2 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6E
| Argyrophilic grain disease type 2 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6A
| Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7OLV
| MerTK kinase domain with type 1.5 inhibitor containing a di-methyl, cyano pyrazole group | 分子名称: | 4-[4-[5-[imidazo[1,2-a]pyridin-6-ylmethyl(methyl)amino]-1,3,4-oxadiazol-2-yl]-3-methyl-phenyl]-2,5-dimethyl-pyrazole-3-carbonitrile, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Winter-Holt, J. | 登録日 | 2021-05-20 | 公開日 | 2021-09-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Optimization of an Imidazo[1,2- a ]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy. J.Med.Chem., 64, 2021
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