2R0R
Crystal Structure of Human Saposin D variant SapD K9E
Summary for 2R0R
Entry DOI | 10.2210/pdb2r0r/pdb |
Related | 2QYP 2R1Q 2RB3 2Z9A |
Descriptor | Proactivator polypeptide, SULFATE ION (3 entities in total) |
Functional Keywords | lipid binding protein, saposin, activator protein, sap, alternative splicing, disease mutation, gaucher disease, glycoprotein, gm2-gangliosidosis, lipid metabolism, lysosome, metachromatic leukodystrophy, sphingolipid metabolism |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome . Prosaposin: Secreted : P07602 |
Total number of polymer chains | 2 |
Total formula weight | 19404.24 |
Authors | Rossmann, M.,Saenger, W.,Maier, T. (deposition date: 2007-08-21, release date: 2008-04-29, Last modification date: 2021-10-20) |
Primary citation | Rossmann, M.,Schultz-Heienbrok, R.,Behlke, J.,Remmel, N.,Alings, C.,Sandhoff, K.,Saenger, W.,Maier, T. Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions. Structure, 16:809-817, 2008 Cited by PubMed: 18462685DOI: 10.1016/j.str.2008.02.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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