4C7M
 
 | | The crystal structure of TcpB or BtpA TIR domain | | Descriptor: | Toll/interleukin-1 receptor domain-containing protein | | Authors: | Alaidarous, M, Ve, T, Casey, L.W, Valkov, E, Ullah, M.O, Schembri, M.A, Mansell, A, Sweet, M.J, Kobe, B. | | Deposit date: | 2013-09-23 | | Release date: | 2013-12-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.
J.Biol.Chem., 289, 2014
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4W2R
 | | Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | | Descriptor: | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ... | | Authors: | Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E. | | Deposit date: | 2017-09-25 | | Release date: | 2017-12-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J. Med. Chem., 61, 2018
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4UDR
 | | Crystal structure of the H467A mutant of 5-hydroxymethylfurfural oxidase (HMFO) | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE | | Authors: | Dijkman, W, Binda, C, Fraaije, M, Mattevi, A. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure-Based Enzyme Tailoring of 5-Hydroxymethylfurfural Oxidase
Acs Catalysis, 5, 2015
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4UDQ
 | | Crystal structure of 5-hydroxymethylfurfural oxidase (HMFO) in the reduced state | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE | | Authors: | Dijkman, W, Binda, C, Fraaije, M, Mattevi, A. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure-Based Enzyme Tailoring of 5-Hydroxymethylfurfural Oxidase
Acs Catalysis, 5, 2015
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4UTF
 | | Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-isofagomine and alpha- 1,2-mannobiose | | Descriptor: | 1,2-ETHANEDIOL, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, GLYCOSYL HYDROLASE FAMILY 71, ... | | Authors: | Cuskin, F, Lowe, E.C, Temple, M.J, Zhu, Y, Pudlo, N.A, Cameron, E.A, Urs, K, Thompson, A.J, Cartmell, A, Rogowski, A, Tolbert, T, Piens, K, Bracke, D, Vervecken, W, Hakki, Z, Speciale, G, Munoz-Munoz, J.L, Pena, M.J, McLean, R, Suits, M.D, Boraston, A.B, Atherly, T, Ziemer, C.J, Williams, S.J, Davies, G.J, Abbott, D.W, Martens, E.C, Gilbert, H.J. | | Deposit date: | 2014-07-21 | | Release date: | 2014-12-24 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Human Gut Bacteroidetes Can Utilize Yeast Mannan Through a Selfish Mechanism.
Nature, 517, 2015
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3MR3
 | | Human DNA polymerase eta - DNA ternary complex with the 3'T of a CPD in the active site (TT1) | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*(TTD)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W. | | Deposit date: | 2010-04-28 | | Release date: | 2010-06-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
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5ZUJ
 | | Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA | | Descriptor: | TNF receptor-associated factor 6, peptide 170-184 from TRAF-interacting protein with FHA domain-containing protein A | | Authors: | Huang, W.C, Maestre-Reyna, M, Hsiao, T.C, Tsai, M.D. | | Deposit date: | 2018-05-07 | | Release date: | 2018-12-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.
Chembiochem, 20, 2019
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6A0E
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621P
 | | THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | | Descriptor: | H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | Authors: | Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. | | Deposit date: | 1991-06-06 | | Release date: | 1994-01-31 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
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4WEQ
 | | Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc02828 (SmGhrA) from Sinorhizobium meliloti in complex with NADP and sulfate | | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Sroka, P, Gasiorowska, O.A, Handing, K.B, Shabalin, I.G, Osinski, T, Hillerich, B.S, Bonanno, J, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2014-09-10 | | Release date: | 2014-09-24 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies.
Biochemistry, 57, 2018
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4WJ7
 | | CCM2 PTB domain in complex with KRIT1 NPxY/F3 | | Descriptor: | KRIT1 NPxY/F3, Malcavernin | | Authors: | Fisher, O.S, Liu, W, Zhang, R, Stiegler, A.L, Boggon, T.J. | | Deposit date: | 2014-09-29 | | Release date: | 2014-12-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.753 Å) | | Cite: | Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations.
J.Biol.Chem., 290, 2015
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8H8C
 | | Type VI secretion system effector RhsP in its post-autoproteolysis and dimeric form | | Descriptor: | C-terminal peptide from Putative Rhs-family protein, Putative Rhs-family protein | | Authors: | Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H. | | Deposit date: | 2022-10-22 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP.
Cell Rep, 41, 2022
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8H8B
 | | Type VI secretion system effector RhsP in its pre-autoproteolysis and monomeric form | | Descriptor: | Putative Rhs-family protein | | Authors: | Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H. | | Deposit date: | 2022-10-22 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP.
Cell Rep, 41, 2022
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8H8A
 | | Type VI secretion system effector RhsP in its post-autoproteolysis and monomeric form | | Descriptor: | C-terminal peptide from Putative Rhs-family protein, Putative Rhs-family protein | | Authors: | Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H. | | Deposit date: | 2022-10-22 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP.
Cell Rep, 41, 2022
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6PVC
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8R6S
 | | Plastid-encoded RNA polymerase (Integrated model) | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Webster, M.W, Pramanick, I, Vergara-Cruces, A. | | Deposit date: | 2023-11-22 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | Structure of the plant plastid-encoded RNA polymerase.
Cell, 187, 2024
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8RDJ
 | | Plastid-encoded RNA polymerase transcription elongation complex (Integrated model) | | Descriptor: | DNA (81-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Webster, M.W, Pramanick, I, Vergara-Cruces, A. | | Deposit date: | 2023-12-08 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.62 Å) | | Cite: | Structure of the plant plastid-encoded RNA polymerase.
Cell, 187, 2024
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8R5O
 | | Plastid-encoded RNA polymerase | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Webster, M.W, Pramanick, I, Vergara-Cruces, A. | | Deposit date: | 2023-11-17 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | Structure of the plant plastid-encoded RNA polymerase.
Cell, 187, 2024
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6PZR
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8SFT
 | | Crystal structure of TuUGT202A2 (Tetur22g00270) in complex with kaempferol | | Descriptor: | 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, SULFATE ION, UDP-glycosyltransferase 202A2, ... | | Authors: | Arriaza, R.H, Dermauw, W, Wybouw, N, Van Leeuwen, T, Chruszcz, M. | | Deposit date: | 2023-04-11 | | Release date: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure of TuUGT202A2 (Tetur22g00270) in complex with kaempferol
To Be Published
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6PVD
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8RMO
 | | Crystal structure of anti-FLAG M2 Fab fragment bound to FLAG-tag peptide epitope | | Descriptor: | CHLORIDE ION, FLAG-tag, anti-FLAG M2 heavy chain, ... | | Authors: | Beugelink, J.W, Janssen, B.J.C, Pronker, M.F. | | Deposit date: | 2024-01-08 | | Release date: | 2024-04-03 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (1.163 Å) | | Cite: | Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2.
J.Mol.Biol., 436, 2024
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8SGN
 | | Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy651H02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. | | Deposit date: | 2023-04-12 | | Release date: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy651H02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine
To Be Published
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4U5M
 | | Structure of a left-handed DNA G-quadruplex | | Descriptor: | DNA (28-MER), MAGNESIUM ION, POTASSIUM ION | | Authors: | Schmitt, E, Mechulam, Y, Phan, A.T, Brahim, H, Chung, W.J, Lim, K.W. | | Deposit date: | 2014-07-25 | | Release date: | 2015-02-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of a left-handed DNA G-quadruplex.
Proc.Natl.Acad.Sci.USA, 112, 2015
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6JJS
 | | Crystal structure of an enzyme from Penicillium herquei in condition2 | | Descriptor: | ACETATE ION, PhnH | | Authors: | Fen, Y, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-02-26 | | Release date: | 2020-01-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei.
Biochem.Biophys.Res.Commun., 516, 2019
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