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PDB: 34568 件
6C1M
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BU of 6c1m by Molmil
NavAb NormoPP mutant
分子名称: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-METHYLGUANIDINE, CHAPSO, ...
著者Catterall, W.A, Zheng, N, Jiang, D, Gamal El-Din, T.M.
登録日2018-01-04
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.518 Å)
主引用文献Structural basis for gating pore current in periodic paralysis.
Nature, 557, 2018
8T6P
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BU of 8t6p by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 2 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-16
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6Y
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BU of 8t6y by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 1 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T7S
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BU of 8t7s by Molmil
SpRYmer bound to NAC PAM DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-21
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T78
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BU of 8t78 by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 8 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6O
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BU of 8t6o by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 0 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-16
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
1O7A
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BU of 1o7a by Molmil
Human beta-Hexosaminidase B
分子名称: 1,2-ETHANEDIOL, 2-(acetylamido)-2-deoxy-D-glucono-1,5-lactone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Maier, T, Strater, N, Schuette, C, Klingenstein, R, Sandhoff, K, Saenger, W.
登録日2002-10-29
公開日2003-10-23
最終更新日2020-11-18
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The X-Ray Crystal Structure of Human Beta-Hexosaminidase B Provides New Insights Into Sandhoff Disease
J.Mol.Biol., 328, 2003
8T6T
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BU of 8t6t by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 13 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-18
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6S
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BU of 8t6s by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 10 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-18
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T77
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BU of 8t77 by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 6 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
3JQ9
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BU of 3jq9 by Molmil
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (AX1)
分子名称: 2-amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1
著者Tulloch, L.B, Hunter, W.N.
登録日2009-09-06
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3JQG
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BU of 3jqg by Molmil
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4-methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (AX6)
分子名称: 6-[(4-methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1
著者Tulloch, L.B, Hunter, W.N.
登録日2009-09-06
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
7UVZ
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BU of 7uvz by Molmil
A. baumannii ribosome-Streptothricin-D complex: 70S with E-site tRNA
分子名称: 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ...
著者Morgan, C.E, Yu, E.W.
登録日2022-05-02
公開日2023-04-19
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.21 Å)
主引用文献Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome.
Plos Biol., 21, 2023
3JQ8
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BU of 3jq8 by Molmil
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine (DX3)
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Tulloch, L.B, Hunter, W.N.
登録日2009-09-06
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
8T6X
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BU of 8t6x by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 18 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
6HE9
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BU of 6he9 by Molmil
PAN-proteasome in state 2
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Majumder, P, Rudack, T, Beck, F, Baumeister, W.
登録日2018-08-20
公開日2018-12-26
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (6.35 Å)
主引用文献Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
7PII
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BU of 7pii by Molmil
Structure of the human CCAN CENP-A alpha-satellite complex
分子名称: Centromere protein C, DNA (122-MER), DNA (123-MER), ...
著者Yatskevich, S, Muir, K.W, Bellini, D, Barford, D.
登録日2021-08-19
公開日2022-05-25
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.68 Å)
主引用文献Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
2Y6X
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BU of 2y6x by Molmil
Structure of Psb27 from Thermosynechococcus elongatus
分子名称: CHLORIDE ION, PHOTOSYSTEM II 11 KD PROTEIN
著者Michoux, F, Takasaka, K, Boehm, M, Nixon, P.J, Murray, J.W.
登録日2011-01-27
公開日2012-01-11
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of the Psb27 Assembly Factor at 1.6A: Implications for Binding to Photosystem II.
Photosynth.Res., 110, 2012
8T79
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BU of 8t79 by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 10 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-20
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8TR1
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BU of 8tr1 by Molmil
Crystal structure of trypanosome brucei hypoxanthine guanine phosphopribosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2- phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
分子名称: (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase
著者Guddat, L.W.
登録日2023-08-09
公開日2024-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
J.Med.Chem., 67, 2024
8TPY
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BU of 8tpy by Molmil
Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R] 4-Guanin-9-yl-2-hydroxymethyl-1-N-(3-phosphonopropionyl)pyrrolidine
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, {3-[(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-oxopropyl}phosphonic acid
著者Guddat, L.W.
登録日2023-08-06
公開日2024-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
J.Med.Chem., 67, 2024
3K9P
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BU of 3k9p by Molmil
The crystal structure of E2-25K and ubiquitin complex
分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 K
著者Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H.
登録日2009-10-16
公開日2010-09-08
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
8TPV
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BU of 8tpv by Molmil
Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
分子名称: (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION
著者Guddat, L.W.
登録日2023-08-05
公開日2024-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
J.Med.Chem., 67, 2024
1NTQ
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BU of 1ntq by Molmil
5'(dCCUCCUU)3':3'(rAGGAGGAAA)5'
分子名称: 5'-D(*CP*CP*UP*CP*CP*UP*U)-3', 5'-R(*AP*AP*AP*GP*GP*AP*GP*GP*A)-3'
著者Znosko, B.M, Barnes III, T.W, Krugh, T.R, Turner, D.H.
登録日2003-01-30
公開日2003-06-10
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献NMR Studies of DNA Single Strands and DNA:RNA Hybrids With and Without 1-Propynylation at C5 of Oligopyrimidines
J.Am.Chem.Soc., 125, 2003
6VYJ
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BU of 6vyj by Molmil
Human UHRF1 TTD domain in complex with a fragment
分子名称: 2,4-dimethylpyridine, E3 ubiquitin-protein ligase UHRF1, beta-D-glucopyranose
著者Campbell, J.C, Chang, L, Young, D.W.
登録日2020-02-26
公開日2021-01-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery.
Sci Rep, 11, 2021

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件を2024-08-21に公開中

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