8ADF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8adf by Molmil](/molmil-images/mine/8adf) | X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ39 | 分子名称: | (2R)-3-(4-bromophenyl)-2-(3-hydroxyphenyl)-4-oxidanyl-2H-furan-5-one, Peroxisome proliferator-activated receptor gamma | 著者 | Capelli, D, Montanari, R, Pochetti, G, Meneghetti, F, Villa, S. | 登録日 | 2022-07-08 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13, 2023
|
|
8C0C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c0c by Molmil](/molmil-images/mine/8c0c) | X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46 | 分子名称: | (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one, Peroxisome proliferator-activated receptor gamma | 著者 | Capelli, D, Montanari, R, Pochetti, G, Villa, S, Meneghetti, F. | 登録日 | 2022-12-16 | 公開日 | 2023-04-26 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13, 2023
|
|
8QIJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qij by Molmil](/molmil-images/mine/8qij) | Crystallographic Structure of a Salicylate Synthase from M. abscessus (Mab-SaS) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Cassetta, A, Covaceuszach, S, Tomaiuolo, M, Meneghetti, F, Villa, S, Mori, M, Chiarelli, L.R, Mangiatordi, G.F. | 登録日 | 2023-09-12 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.073 Å) | 主引用文献 | Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus. Eur.J.Med.Chem., 265, 2024
|
|
8QN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qn5 by Molmil](/molmil-images/mine/8qn5) | M. tuberculosis salicylate synthase MbtI in complex with methyl-AMT (new crystal form) | 分子名称: | 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, AMMONIUM ION, CITRATE ANION, ... | 著者 | Mori, M, Villa, S, Meneghetti, M, Bellinzoni, M. | 登録日 | 2023-09-25 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.544 Å) | 主引用文献 | Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery. Pharmaceuticals, 16, 2023
|
|
8QC4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qc4 by Molmil](/molmil-images/mine/8qc4) | M. tuberculosis salicylate synthase MbtI in complex with 5-(3-carboxyphenyl)furan-2-carboxylic acid | 分子名称: | 5-(3-carboxyphenyl)furan-2-carboxylic acid, GLYCEROL, SULFATE ION, ... | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | 登録日 | 2023-08-25 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.578 Å) | 主引用文献 | Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery. Pharmaceuticals, 16, 2023
|
|
6ZA4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6za4 by Molmil](/molmil-images/mine/6za4) | M. tuberculosis salicylate synthase MbtI in complex with 5-(3-cyanophenyl)furan-2-carboxylate | 分子名称: | 5-(3-cyanophenyl)furan-2-carboxylic acid, CHLORIDE ION, Salicylate synthase | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | 登録日 | 2020-06-04 | 公開日 | 2020-07-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design. J.Med.Chem., 63, 2020
|
|
6ZA6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6za6 by Molmil](/molmil-images/mine/6za6) | M. tuberculosis salicylate synthase MbtI in complex with Ba2+ | 分子名称: | BARIUM ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | 登録日 | 2020-06-04 | 公開日 | 2020-07-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.804 Å) | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design. J.Med.Chem., 63, 2020
|
|
6ZA5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6za5 by Molmil](/molmil-images/mine/6za5) | M. tuberculosis salicylate synthase MbtI in complex with salicylate and Mg2+ | 分子名称: | 2-HYDROXYBENZOIC ACID, ACETATE ION, MAGNESIUM ION, ... | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | 登録日 | 2020-06-04 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.109 Å) | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design. J.Med.Chem., 63, 2020
|
|
8QE4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qe4 by Molmil](/molmil-images/mine/8qe4) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | 分子名称: | DNA (5'-D(*CP*(FRG)P*CP*(FRG)P*CP*(FRG))-3') | 著者 | El-Khoury, R, Cabrero, C, Movilla, S, Friedland, D, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M. | 登録日 | 2023-08-30 | 公開日 | 2024-06-26 | 実験手法 | SOLUTION NMR | 主引用文献 | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 2024
|
|
8QDU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qdu by Molmil](/molmil-images/mine/8qdu) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | 分子名称: | DNA (5'-D(*(FC)P*GP*(FC)P*GP*(FC)P*G)-3') | 著者 | El-Khoury, R, Cabrero, C, Movilla, S, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M.J. | 登録日 | 2023-08-30 | 公開日 | 2024-06-26 | 実験手法 | SOLUTION NMR | 主引用文献 | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 2024
|
|
8QOR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qor by Molmil](/molmil-images/mine/8qor) | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions | 分子名称: | DNA (5'-D(*(CFL)P*(FRG)P*(CFL)P*(FRG)P*(CFL)P*(FRG))-3') | 著者 | El-Khoury, R, Cabrero, C, Movilla, S, Friedland, D, Thorpe, J.D, Roman, M, Orozco, M, Gonzalez, C, Damha, M. | 登録日 | 2023-09-29 | 公開日 | 2024-06-26 | 実験手法 | SOLUTION NMR | 主引用文献 | Formation of left-handed helices by C2'-fluorinated nucleic acids under physiological salt conditions. Nucleic Acids Res., 2024
|
|