8QIJ

Crystallographic Structure of a Salicylate Synthase from M. abscessus (Mab-SaS)

This is a non-PDB format compatible entry.

Summary for 8QIJ

• Entry DOI: 10.2210/pdb8qij/pdb
• Descriptor: Putative anthranilate synthase component I TrpE2/ Salicylate synthase MbtI, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... (6 entities in total)
• Functional Keywords: synthase, siderophore, iron acquisition, biosynthetic protein
• Biological source: Mycobacteroides abscessus
• Total number of polymer chains: 2
• Total formula weight: 99208.40

Authors

Cassetta, A.,Covaceuszach, S.,Tomaiuolo, M.,Meneghetti, F.,Villa, S.,Mori, M.,Chiarelli, L.R.,Mangiatordi, G.F. (deposition date: 2023-09-12, release date: 2024-01-31, Last modification date: 2024-02-07)

• Primary citation: Mori, M.,Cocorullo, M.,Tresoldi, A.,Cazzaniga, G.,Gelain, A.,Stelitano, G.,Chiarelli, L.R.,Tomaiuolo, M.,Delre, P.,Mangiatordi, G.F.,Garofalo, M.,Cassetta, A.,Covaceuszach, S.,Villa, S.,Meneghetti, F.; Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus.; Eur.J.Med.Chem., 265:116073-116073, 2024; PubMed: 38169270; DOI: 10.1016/j.ejmech.2023.116073

Experimental method

X-RAY DIFFRACTION (2.073 Å)