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PDB: 204 results

4YHX
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BU of 4yhx by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-GpeMI Bound to Uncleaved DNA
Descriptor: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein
Authors:Hallinan, J.P, Kaiser, B.K, Stoddard, B.L.
Deposit date:2015-02-27
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4Z20
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BU of 4z20 by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTGT Central Four
Descriptor: CALCIUM ION, DNA (26-MER), GLYCEROL, ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2015-03-27
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
3UGM
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BU of 3ugm by Molmil
Structure of TAL effector PthXo1 bound to its DNA target
Descriptor: DNA-1, DNA-2, TAL effector AvrBs3/PthA
Authors:Mak, A.N.S, Bradley, P, Cernadas, R.A, Bogdanove, A.J, Stoddard, B.L.
Deposit date:2011-11-02
Release date:2012-01-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target.
Science, 335, 2012
3M7K
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BU of 3m7k by Molmil
Crystal structure of PacI-DNA Enzyme product complex
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*TP*TP*AP*AP*T)-3'), DNA (5'-D(P*TP*AP*AP*GP*CP*CP*TP*C)-3'), ...
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2010-03-16
Release date:2010-04-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI.
Structure, 18, 2010
4QPZ
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BU of 4qpz by Molmil
Crystal structure of the formolase FLS_v2 in space group P 21
Descriptor: Formolase, MAGNESIUM ION, THIAMINE DIPHOSPHATE
Authors:Shen, B.W, Siegel, J.B, Stoddard, B.L, Baker, D.
Deposit date:2014-06-25
Release date:2015-03-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Computational protein design enables a novel one-carbon assimilation pathway.
Proc.Natl.Acad.Sci.USA, 112, 2015
3U0S
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BU of 3u0s by Molmil
Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Diisopropyl-fluorophosphatase, GLYCEROL, ...
Authors:Bale, J.B, Shen, B.W, Stoddard, B.L.
Deposit date:2011-09-29
Release date:2012-02-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.
Nat.Biotechnol., 30, 2012
3HYJ
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BU of 3hyj by Molmil
Crystal structure of the N-terminal LAGLIDADG domain of DUF199/WhiA
Descriptor: CHLORIDE ION, GLYCEROL, Protein DUF199/WhiA, ...
Authors:Kaiser, B.K, Clifton, M.C, Shen, B.W, Stoddard, B.L.
Deposit date:2009-06-22
Release date:2009-09-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease.
Structure, 17, 2009
3HYI
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BU of 3hyi by Molmil
Crystal structure of full-length DUF199/WhiA from Thermatoga maritima
Descriptor: GLYCEROL, Protein DUF199/WhiA, SODIUM ION
Authors:Kaiser, B.K, Clifton, M.C, Shen, B.W, Stoddard, B.L.
Deposit date:2009-06-22
Release date:2009-09-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease
Structure, 17, 2009
3C25
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BU of 3c25 by Molmil
Crystal Structure of NotI Restriction Endonuclease Bound to Cognate DNA
Descriptor: CALCIUM ION, DNA (5'-D(*DCP*DGP*DGP*DAP*DGP*DGP*DCP*DGP*DCP*DGP*DGP*DCP*DCP*DGP*DCP*DGP*DCP*DCP*DGP*DCP*DCP*DG)-3'), DNA (5'-D(*DCP*DGP*DGP*DCP*DGP*DGP*DCP*DGP*DCP*DGP*DGP*DCP*DCP*DGP*DCP*DGP*DCP*DCP*DTP*DCP*DCP*DG)-3'), ...
Authors:Lambert, A.R, Sussman, D, Shen, B, Stoddard, B.L.
Deposit date:2008-01-24
Release date:2008-02-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the Rare-Cutting Restriction Endonuclease NotI Reveal a Unique Metal Binding Fold Involved in DNA Binding.
Structure, 16, 2008
5TGX
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BU of 5tgx by Molmil
Restriction/modification system-Type II R-SwaI complexed with partially cleaved DNA
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2016-09-28
Release date:2016-12-21
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target.
Nucleic Acids Res., 45, 2017
3QQY
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BU of 3qqy by Molmil
Crystal structure of a novel LAGLIDADG homing endonuclease, I-OnuI (from Ophiostoma novo-ulmi subsp. americana)
Descriptor: DNA (26-MER), MAGNESIUM ION, Ribosomal protein 3/homing endonuclease-like protein fusion
Authors:Takeuchi, R, Stoddard, B.L.
Deposit date:2011-02-16
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Tapping natural reservoirs of homing endonucleases for targeted gene modification.
Proc.Natl.Acad.Sci.USA, 108, 2011
8ETQ
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BU of 8etq by Molmil
Designed pentafoil knot protein folded into a trefoil knot
Descriptor: k-cTRP5
Authors:Doyle, L.A, Kibler, R.D, Bradley, P, Stoddard, B.L.
Deposit date:2022-10-17
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:De novo design of knotted tandem repeat proteins.
Nat Commun, 14, 2023
3R7P
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BU of 3r7p by Molmil
The crystal structure of I-LtrI
Descriptor: DNA (5'-D(*CP*AP*AP*AP*TP*GP*CP*TP*CP*CP*TP*AP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*GP*CP*AP*TP*TP*TP*G)-3'), ...
Authors:Mak, A.N.S, Takeuchi, R, Edgell, D.R, Stoddard, B.L.
Deposit date:2011-03-22
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Tapping natural reservoirs of homing endonucleases for targeted gene modification.
Proc.Natl.Acad.Sci.USA, 108, 2011
4R6J
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BU of 4r6j by Molmil
Crystal structure of computaional designed Lucine rich repeats DLRR_H in space group P212121
Descriptor: Lucine rich repeats DLRR_H, SULFATE ION
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2014-08-25
Release date:2015-01-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Control of repeat-protein curvature by computational protein design.
Nat.Struct.Mol.Biol., 22, 2015
1YSB
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BU of 1ysb by Molmil
Yeast Cytosine Deaminase Triple Mutant
Descriptor: CALCIUM ION, Cytosine deaminase, ZINC ION
Authors:Korkegian, A, Black, M.E, Baker, D, Stoddard, B.L.
Deposit date:2005-02-08
Release date:2005-05-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational thermostabilization of an enzyme.
Science, 308, 2005
4YY2
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BU of 4yy2 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P212121
Descriptor: SODIUM ION, dTor_3x33L
Authors:Hallinan, J.P, Bradley, P, Stoddard, B.L.
Deposit date:2015-03-23
Release date:2015-12-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
1M5X
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BU of 1m5x by Molmil
Crystal structure of the homing endonuclease I-MsoI bound to its DNA substrate
Descriptor: 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ...
Authors:Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L.
Deposit date:2002-07-10
Release date:2003-06-03
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
J.Mol.Biol., 329, 2003
3BVQ
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BU of 3bvq by Molmil
Crystal Structure of Apo NotI Restriction Endonuclease
Descriptor: FE (III) ION, NotI restriction endonuclease, SULFATE ION
Authors:Lambert, A.R, Sussman, D, Shen, B, Stoddard, B.L.
Deposit date:2008-01-07
Release date:2008-01-22
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the Rare-Cutting Restriction Endonuclease NotI Reveal a Unique Metal Binding Fold Involved in DNA Binding.
Structure, 16, 2008
2O3K
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BU of 2o3k by Molmil
Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY
Descriptor: 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, CALCIUM ION, Cytosine deaminase, ...
Authors:Korkegian, A.M, Stoddard, B.L.
Deposit date:2006-12-01
Release date:2007-10-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY
To be Published
1YSD
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BU of 1ysd by Molmil
Yeast Cytosine Deaminase Double Mutant
Descriptor: CALCIUM ION, Cytosine deaminase, ZINC ION
Authors:Korkegian, A, Black, M.E, Baker, D, Stoddard, B.L.
Deposit date:2005-02-08
Release date:2005-05-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational thermostabilization of an enzyme.
Science, 308, 2005
4Z1Z
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BU of 4z1z by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTCT Central Four
Descriptor: CALCIUM ION, DNA (28-MER), GLYCEROL, ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2015-03-27
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
5TH3
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BU of 5th3 by Molmil
Restriction/modification system-Type II R.SwaI cleaved DNA complex
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (cleaved 25-MER, ...
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2016-09-29
Release date:2016-12-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target.
Nucleic Acids Res., 45, 2017
1N3E
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BU of 1n3e by Molmil
Crystal structure of I-CreI bound to a palindromic DNA sequence I (palindrome of left side of wildtype DNA target sequence)
Descriptor: 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3', 5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*CP*G)-3', CALCIUM ION, ...
Authors:Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L.
Deposit date:2002-10-28
Release date:2003-06-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
J.Mol.Biol., 329, 2003
8EM1
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BU of 8em1 by Molmil
Type IIS Restriction Endonuclease PaqCI, DNA Unbound
Descriptor: 1,2-ETHANEDIOL, PaqCI, DNA Unbound
Authors:Kennedy, M.A, Stoddard, B.L.
Deposit date:2022-09-26
Release date:2023-03-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures, activity and mechanism of the Type IIS restriction endonuclease PaqCI.
Nucleic Acids Res., 51, 2023
2EX5
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BU of 2ex5 by Molmil
Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA
Descriptor: CALCIUM ION, DNA endonuclease I-CeuI, I-CeuI DNA target site, ...
Authors:Spiegel, P.C, Stoddard, B.L.
Deposit date:2005-11-07
Release date:2006-05-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold.
Structure, 14, 2006

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数据于2024-07-24公开中

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