6DFK
| Crystal structure of the 11S subunit of the Plasmodium falciparum proteasome, PA28 | 分子名称: | SULFATE ION, Subunit of proteaseome activator complex,putative | 著者 | Xie, S.C, Metcalfe, R.D, Gillett, D.L, Tilley, L, Griffin, M.D.W. | 登録日 | 2018-05-15 | 公開日 | 2019-08-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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5FMG
| Structure and function based design of Plasmodium-selective proteasome inhibitors | 分子名称: | (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide, BETA3 PROTEASOME SUBUNIT, PUTATIVE, ... | 著者 | Li, H, O'Donoghue, A.J, van der Linden, W.A, Xie, S.C, Yoo, E, Foe, I.T, Tilley, L, Craik, C.S, da Fonseca, P.C.A, Bogyo, M. | 登録日 | 2015-11-04 | 公開日 | 2016-03-02 | 最終更新日 | 2017-08-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and Function Based Design of Plasmodium-Selective Proteasome Inhibitors Nature, 530, 2016
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1YWG
| The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, glyceraldehyde-3-phosphate dehydrogenase | 著者 | Satchell, J.F, Klonis, N, Malby, R.L, Adisa, A, Alpyurek, A.E, Colman, P.M, Tilley, L. | 登録日 | 2005-02-17 | 公開日 | 2005-11-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum. Acta Crystallogr.,Sect.D, 61, 2005
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8TC8
| Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate | 分子名称: | 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparagine--tRNA ligase, cytoplasmic, ... | 著者 | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | 登録日 | 2023-06-30 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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8TC9
| Human asparaginyl-tRNA synthetase bound to OSM-S-106 | 分子名称: | Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ... | 著者 | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | 登録日 | 2023-06-30 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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8TC7
| Human asparaginyl-tRNA synthetase, apo form | 分子名称: | Asparagine--tRNA ligase, cytoplasmic, CHLORIDE ION, ... | 著者 | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | 登録日 | 2023-06-30 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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6MUV
| The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators | 分子名称: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | 著者 | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | 登録日 | 2018-10-23 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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6MUX
| The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator | 分子名称: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | 著者 | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | 登録日 | 2018-10-23 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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6MUW
| The structure of the Plasmodium falciparum 20S proteasome. | 分子名称: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | 著者 | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | 登録日 | 2018-10-23 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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7ROR
| Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP | 分子名称: | 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | 登録日 | 2021-08-02 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376, 2022
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7ROS
| Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ... | 著者 | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | 登録日 | 2021-08-02 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376, 2022
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7ROU
| Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr | 分子名称: | SULFATE ION, Tyrosine--tRNA ligase, cytoplasmic, ... | 著者 | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | 登録日 | 2021-08-02 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376, 2022
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7ROT
| Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ... | 著者 | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | 登録日 | 2021-08-02 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376, 2022
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7LXV
| Structure of human 20S proteasome with bound MPI-5 | 分子名称: | N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | 著者 | Metcalfe, R.D, Morton, C.J, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W. | 登録日 | 2021-03-05 | 公開日 | 2021-09-22 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118, 2021
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7LXT
| Structure of Plasmodium falciparum 20S proteasome with bound bortezomib | 分子名称: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | 著者 | Morton, C.J, Metcalfe, R.D, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W. | 登録日 | 2021-03-05 | 公開日 | 2021-09-22 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118, 2021
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7LXU
| Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 | 分子名称: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | 著者 | Metcalfe, R.D, Morton, C.J, Xie, S.C, Liu, B, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W. | 登録日 | 2021-03-05 | 公開日 | 2021-09-22 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118, 2021
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