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PDB: 437 件

5JT2
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BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-BISAMIDE
分子名称: 2,2'-oxybis(N-{[4-(3-{2,6-difluoro-3-[(propane-1-sulfonyl)amino]benzoyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]methyl}acetamide), BENZAMIDINE, Serine/threonine-protein kinase B-raf
著者Grasso, M.J, Marmorstein, R.
登録日2016-05-09
公開日2016-09-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.702 Å)
主引用文献Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Acs Chem.Biol., 11, 2016
6TTR
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BU of 6ttr by Molmil
Crystal Structure of the coiled coil and GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), GGDEF diguanylate cyclase DgcB, PHOSPHATE ION
著者Holzschuh, F, Schirmer, T, Teixeira, R.D.
登録日2019-12-30
公開日2021-01-13
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystal structure of the coiled coil and GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP
To Be Published
6TTS
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BU of 6tts by Molmil
Crystal structure of the GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), GGDEF diguanylate cyclase DgcB, SULFATE ION
著者Holzschuh, F, Schirmer, T, Teixeira, R.
登録日2019-12-30
公開日2021-01-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the GGDEF domain of DgcB from Caulobacter crescentus in complex with c-di-GMP
To Be Published
7RB3
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Cryo-EM structure of human binary NatC complex with a Bisubstrate inhibitor
分子名称: CARBOXYMETHYL COENZYME *A, LEUCINE, METHIONINE, ...
著者Deng, S, Marmorstein, R.
登録日2021-07-05
公開日2023-01-11
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure, 31, 2023
6UIA
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BU of 6uia by Molmil
Structure of ATP citrate lyase with CoA in a partially open conformation
分子名称: ATP-citrate synthase, COENZYME A
著者Wei, X, Marmorstein, R.
登録日2019-09-30
公開日2019-12-25
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Molecular basis for acetyl-CoA production by ATP-citrate lyase.
Nat.Struct.Mol.Biol., 27, 2020
8G0L
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BU of 8g0l by Molmil
Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies
分子名称: Alpha-synuclein, CARBOXYMETHYL COENZYME *A, N-alpha-acetyltransferase 20, ...
著者Gardner, S.M, Marmorstein, R.
登録日2023-01-31
公開日2023-05-03
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
Biorxiv, 2023
4PZR
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BU of 4pzr by Molmil
Crystal structure of p300 histone acetyltransferase domain in complex with Coenzyme A
分子名称: COENZYME A, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
著者Maksimoska, J, Marmorstein, R.
登録日2014-03-31
公開日2014-06-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues.
Biochemistry, 53, 2014
4PZS
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BU of 4pzs by Molmil
Crystal structure of p300 histone acetyltransferase domain in complex with Acetyl-Coenzyme A
分子名称: ACETYL COENZYME *A, DIMETHYL SULFOXIDE, Histone acetyltransferase p300
著者Maksimoska, J, Marmorstein, R.
登録日2014-03-31
公開日2014-06-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues.
Biochemistry, 53, 2014
4KVO
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BU of 4kvo by Molmil
The NatA (Naa10p/Naa15p) amino-terminal acetyltrasferase complex bound to AcCoA
分子名称: ACETYL COENZYME *A, CHLORIDE ION, N-terminal acetyltransferase A complex catalytic subunit ard1, ...
著者Liszczak, G.P, Marmorstein, R.Q.
登録日2013-05-22
公開日2013-07-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Molecular basis for N-terminal acetylation by the heterodimeric NatA complex.
Nat.Struct.Mol.Biol., 20, 2013
4KVM
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BU of 4kvm by Molmil
The NatA (Naa10p/Naa15p) amino-terminal acetyltransferase complex bound to a bisubstrate analog
分子名称: CHLORIDE ION, N-terminal acetyltransferase A complex catalytic subunit ard1, N-terminal acetyltransferase A complex subunit nat1, ...
著者Liszczak, G.P, Marmorstein, R.Q.
登録日2013-05-22
公開日2013-07-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.597 Å)
主引用文献Molecular basis for N-terminal acetylation by the heterodimeric NatA complex.
Nat.Struct.Mol.Biol., 20, 2013
4R5K
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BU of 4r5k by Molmil
Crystal structure of the DnaK C-terminus (Dnak-SBD-B)
分子名称: CALCIUM ION, Chaperone protein DnaK, SULFATE ION
著者Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
登録日2014-08-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7469 Å)
主引用文献Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
5SZR
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BU of 5szr by Molmil
Protocadherin Gamma B2 extracellular cadherin domains 3-6
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Goodman, K.M, Mannepalli, S, Bahna, F, Rubinstein, R, Honig, B, Shapiro, L.
登録日2016-08-14
公開日2016-10-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献gamma-Protocadherin structural diversity and functional implications.
Elife, 5, 2016
4R5J
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BU of 4r5j by Molmil
Crystal structure of the DnaK C-terminus (Dnak-SBD-A)
分子名称: CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION
著者Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
登録日2014-08-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.361 Å)
主引用文献Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
5FM4
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BU of 5fm4 by Molmil
Structure of the C-terminally extended domain My4 of human myomesin (space group P21)
分子名称: MYOMESIN-1
著者Pernigo, S, Steiner, R.A.
登録日2015-10-30
公開日2016-11-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.
Structure, 25, 2017
4R5G
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BU of 4r5g by Molmil
Crystal structure of the DnaK C-terminus with the inhibitor PET-16
分子名称: Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium
著者Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
登録日2014-08-21
公開日2014-09-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.4501 Å)
主引用文献Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
4R5I
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BU of 4r5i by Molmil
Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG
分子名称: Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ...
著者Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
登録日2014-08-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9702 Å)
主引用文献Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
7KD7
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BU of 7kd7 by Molmil
Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AMINO GROUP, CARBOXYMETHYL COENZYME *A, ...
著者Deng, S, Marmorstein, R.
登録日2020-10-08
公開日2021-06-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
J.Med.Chem., 64, 2021
7KPU
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BU of 7kpu by Molmil
Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue with a C-3 linker
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETYL GROUP, AMINO GROUP, ...
著者Deng, S, Marmorstein, R.
登録日2020-11-12
公開日2021-06-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
J.Med.Chem., 64, 2021
4ZPO
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BU of 4zpo by Molmil
Crystal Structure of Protocadherin Gamma C5 EC1-3
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, MCG133388, ...
著者Wolcott, H.N, Goodman, K.M, Bahna, F, Mannepalli, S, Rubinstein, R, Honig, B, Shapiro, L.
登録日2015-05-08
公開日2015-10-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015
4KVX
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BU of 4kvx by Molmil
Crystal structure of Naa10 (Ard1) bound to AcCoA
分子名称: ACETYL COENZYME *A, N-terminal acetyltransferase A complex catalytic subunit ard1
著者Liszczak, G.P, Marmorstein, R.Q.
登録日2013-05-23
公開日2013-07-31
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for N-terminal acetylation by the heterodimeric NatA complex.
Nat.Struct.Mol.Biol., 20, 2013
8RWK
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BU of 8rwk by Molmil
cryoEM structure of the central Ald4 filament determined by FilamentID
分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium-activated aldehyde dehydrogenase, mitochondrial
著者Hugener, J, Xu, J, Wettstein, R, Ioannidi, L, Velikov, D, Wollweber, F, Henggeler, A, Matos, J, Pilhofer, M.
登録日2024-02-05
公開日2024-06-26
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis.
Cell, 187, 2024
1XGV
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BU of 1xgv by Molmil
Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix
分子名称: Isocitrate dehydrogenase
著者Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N.-K, Ladenstein, R.
登録日2004-09-17
公開日2005-09-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability
J.Mol.Biol., 345, 2005
7LJ9
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BU of 7lj9 by Molmil
Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate
分子名称: ACETYL COENZYME *A, ATP-citrate synthase, OXALOACETATE ION
著者Wei, X, Marmorstein, R.
登録日2021-01-28
公開日2021-03-31
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Nat.Struct.Mol.Biol., 28, 2021
1ZX2
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BU of 1zx2 by Molmil
Crystal Structure of Yeast UBP3-associated Protein BRE5
分子名称: UBP3-associated protein BRE5
著者Li, K, Zhao, K, Ossareh-Nazari, B, Da, G, Dargemont, C, Marmorstein, R.
登録日2005-06-06
公開日2005-06-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor
J.Biol.Chem., 280, 2005
3ZFW
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BU of 3zfw by Molmil
Crystal structure of the TPR domain of kinesin light chain 2 in complex with a tryptophan-acidic cargo peptide
分子名称: KINESIN LIGHT CHAIN 2, PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2
著者Pernigo, S, Lamprecht, A, Steiner, R.A, Dodding, M.P.
登録日2012-12-12
公開日2013-04-03
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Basis for Kinesin-1:Cargo Recognition.
Science, 340, 2013

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