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PDB: 189 件
6KIK
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BU of 6kik by Molmil
Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor tolrestat
分子名称: Oxidoreductase, aldo/keto reductase family, TOLRESTAT
著者Zhang, C.Y, Liu, X.M, Wang, C, Tang, W.R.
登録日2019-07-18
公開日2019-09-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
Febs Lett., 594, 2020
2PQ3
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BU of 2pq3 by Molmil
N-Terminal Calmodulin Zn-Trapped Intermediate
分子名称: CACODYLATE ION, Calmodulin, ZINC ION
著者Warren, J.T, Guo, Q, Tang, W.J.
登録日2007-05-01
公開日2007-10-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step.
J.Mol.Biol., 374, 2007
7VRT
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BU of 7vrt by Molmil
The unexpanded head structure of phage T4
分子名称: Capsid vertex protein, Major capsid protein
著者Fang, Q, Tang, W, Fokine, A, Mahalingam, M, Shao, Q, Rossmann, M.G, Rao, V.B.
登録日2021-10-24
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly.
Proc.Natl.Acad.Sci.USA, 119, 2022
7VS5
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The expanded head structure of phage T4
分子名称: Capsid vertex protein, Major capsid protein, Small outer capsid protein
著者Fang, Q, Tang, W, Fokine, A, Mahalingam, M, Shao, Q, Rossmann, M.G, Rao, V.B.
登録日2021-10-25
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly.
Proc.Natl.Acad.Sci.USA, 119, 2022
4DWK
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BU of 4dwk by Molmil
Structure of cystein free insulin degrading enzyme with compound bdm41671 ((s)-2-{2-[carboxymethyl-(3-phenyl-propyl)-amino]-acetylamino}-3-(1h-imidazol-4-yl)-propionic acid methyl ester)
分子名称: Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-02-24
公開日2013-04-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DTT
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BU of 4dtt by Molmil
Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367
分子名称: 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, Insulin-degrading enzyme, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-02-21
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4KO8
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BU of 4ko8 by Molmil
Structure of p97 N-D1 R155H mutant in complex with ATPgS
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
著者Xia, D, Tang, W.K.
登録日2013-05-11
公開日2013-11-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
7EHW
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BU of 7ehw by Molmil
BRD4-BD1 in complex with LT-642-602
分子名称: 1-[4-ethyl-2-methyl-5-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
著者Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
登録日2021-03-30
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献BRD4-BD1 in complex with LT-642-602
To Be Published
7EHY
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BRD4-BD1 in complex with LT-448-138
分子名称: 1-[2,4-dimethyl-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
著者Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
登録日2021-03-30
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献BRD4-BD1 in complex with LT-642-602
To Be Published
7EIG
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BRD4-BD1 in complex with LT-730-903
分子名称: 1-[5-(5-azanyl-1H-benzimidazol-2-yl)-2-methyl-4-phenyl-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
著者Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
登録日2021-03-31
公開日2022-04-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献BRD4-BD1 in complex with LT-730-903
To Be Published
7EIK
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RD4-BD1 in complex with LT-872-297
分子名称: 1-[2-methyl-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-4-(1-methylpyrazol-4-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4
著者Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
登録日2021-03-31
公開日2022-04-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献RD4-BD1 in complex with LT-872-297
To Be Published
7EIL
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BRD4-BD1 in complex with LT-909-110
分子名称: Bromodomain-containing protein 4, N-[4-[4-ethanoyl-5-methyl-2-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]phenyl]ethanamide
著者Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y.
登録日2021-03-31
公開日2022-04-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy
Eur.J.Med.Chem., 227, 2022
7E2W
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BU of 7e2w by Molmil
Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with isocitrate and magnesium(II)
分子名称: CITRATE ANION, GLYCEROL, ISOCITRIC ACID, ...
著者Zhu, G.P, Tang, W.G, Wang, P.
登録日2021-02-07
公開日2021-05-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs.
Arch.Biochem.Biophys., 708, 2021
6J11
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BU of 6j11 by Molmil
MERS-CoV spike N-terminal domain and 7D10 scFv complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-terminal domain of Spike glycoprotein, ...
著者Zhou, H, Zhang, S, Zhang, S, Tang, W, Wang, X.
登録日2018-12-27
公開日2019-07-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein.
Nat Commun, 10, 2019

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