7ZOB
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![BU of 7zob by Molmil](/molmil-images/mine/7zob) | Metagenomic cytidine deaminase Cdd | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Metagenomic cytidine deaminase Cdd, SULFATE ION, ... | 著者 | Tamulaitiene, G, Urbeliene, N, Meskys, R. | 登録日 | 2022-04-25 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Cytidine deaminases catalyze the conversion of N ( S , O ) 4 -substituted pyrimidine nucleosides. Sci Adv, 9, 2023
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7BB5
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8PM4
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![BU of 8pm4 by Molmil](/molmil-images/mine/8pm4) | Cryo-EM structure of the Cas12m-crRNA-target DNA complex | 分子名称: | DNA oligoduplex, non-target strand, chain D, ... | 著者 | Sasnauskas, G, Tamulaitiene, G, Karvelis, T, Bigelyte, G, Siksnys, V. | 登録日 | 2023-06-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing. Nucleic Acids Res., 52, 2024
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4ABT
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![BU of 4abt by Molmil](/molmil-images/mine/4abt) | Crystal structure of Type IIF restriction endonuclease NgoMIV with cognate uncleaved DNA | 分子名称: | 5'-D(*TP*GP*CP*GP*CP*CP*GP*GP*CP*GP*CP)-3', CALCIUM ION, TYPE-2 RESTRICTION ENZYME NGOMIV | 著者 | Manakova, E.N, Grazulis, S, Zaremba, M, Tamulaitiene, G, Golovenko, D, Siksnys, V. | 登録日 | 2011-12-11 | 公開日 | 2011-12-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structure of Type Iif Restriction Endonuclease Ngomiv with Cognate Uncleaved DNA To be Published
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8EXA
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![BU of 8exa by Molmil](/molmil-images/mine/8exa) | ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 1 (RuvC domain resolved) | 分子名称: | DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB | 著者 | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V. | 登録日 | 2022-10-25 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature, 616, 2023
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8EX9
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![BU of 8ex9 by Molmil](/molmil-images/mine/8ex9) | ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 2 (RuvC domain unresolved) | 分子名称: | DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB | 著者 | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V. | 登録日 | 2022-10-25 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature, 616, 2023
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2C1L
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![BU of 2c1l by Molmil](/molmil-images/mine/2c1l) | Structure of the BfiI restriction endonuclease | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICARBONATE ION, ... | 著者 | Grazulis, S, Manakova, E, Roessle, M, Bochtler, M, Tamulaitiene, G, Huber, R, Siksnys, V. | 登録日 | 2005-09-15 | 公開日 | 2005-10-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of the Metal-Independent Restriction Enzyme Bfii Reveals Fusion of a Specific DNA-Binding Domain with a Nonspecific Nuclease. Proc.Natl.Acad.Sci.USA, 102, 2005
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3SBH
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![BU of 3sbh by Molmil](/molmil-images/mine/3sbh) | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, BICINE, ... | 著者 | Grazulis, S, Manakova, E, Tamulaitiene, G. | 登録日 | 2011-06-05 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51, 2012
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4RZL
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![BU of 4rzl by Molmil](/molmil-images/mine/4rzl) | |
8PJ9
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8PK1
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![BU of 8pk1 by Molmil](/molmil-images/mine/8pk1) | Cas1-Cas2 CRISPR integrase bound to prespacer DNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, Chains: G,J, ... | 著者 | Sasnauskas, G, Gaizauskaite, U, Tamulaitiene, G. | 登録日 | 2023-06-23 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structural basis for spacer acquisition in a type II-A CRISPR-Cas system To Be Published
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8Q2N
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3HQF
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![BU of 3hqf by Molmil](/molmil-images/mine/3hqf) | Crystal structure of restriction endonuclease EcoRII N-terminal effector-binding domain in complex with cognate DNA | 分子名称: | 5'-D(*CP*GP*CP*CP*AP*GP*GP*GP*C)-3', 5'-D(*GP*CP*CP*CP*TP*GP*GP*CP*G)-3', Restriction endonuclease | 著者 | Golovenko, D, Manakova, E, Grazulis, S, Tamulaitiene, G, Siksnys, V. | 登録日 | 2009-06-06 | 公開日 | 2009-09-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Structural mechanisms for the 5'-CCWGG sequence recognition by the N- and C-terminal domains of EcoRII. Nucleic Acids Res., 37, 2009
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3HQG
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![BU of 3hqg by Molmil](/molmil-images/mine/3hqg) | Crystal structure of restriction endonuclease EcoRII catalytic C-terminal domain in complex with cognate DNA | 分子名称: | 5'-D(*TP*AP*GP*CP*CP*TP*GP*GP*TP*CP*GP*A)-3', 5'-D(*TP*CP*GP*AP*CP*CP*AP*GP*GP*CP*TP*A)-3', GLYCEROL, ... | 著者 | Golovenko, D, Manakova, E, Grazulis, S, Tamulaitiene, G, Siksnys, V. | 登録日 | 2009-06-06 | 公開日 | 2009-09-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural mechanisms for the 5'-CCWGG sequence recognition by the N- and C-terminal domains of EcoRII. Nucleic Acids Res., 37, 2009
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8BF8
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![BU of 8bf8 by Molmil](/molmil-images/mine/8bf8) | ISDra2 TnpB in complex with reRNA | 分子名称: | Deinococcus radiodurans R1 chromosome 1, RNA-guided DNA endonuclease TnpB | 著者 | Sasnauskas, G, Tamulaitiene, G, Carabias, A, Siksnys, V, Montoya, G, Druteika, G, Silanskas, A, Venclovas, C, Karvelis, T, Kazlauskas, D. | 登録日 | 2022-10-24 | 公開日 | 2023-04-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature, 616, 2023
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3SAP
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![BU of 3sap by Molmil](/molmil-images/mine/3sap) | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-{[(5-butylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, BICINE, ... | 著者 | Grazulis, S, Manakova, E, Tamulaitiene, G. | 登録日 | 2011-06-03 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51, 2012
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3SAX
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![BU of 3sax by Molmil](/molmil-images/mine/3sax) | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide | 分子名称: | 2-chloro-5-{[(5-ethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | 著者 | Grazulis, S, Manakova, E, Tamulaitiene, G. | 登録日 | 2011-06-03 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51, 2012
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3S8X
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![BU of 3s8x by Molmil](/molmil-images/mine/3s8x) | Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide | 分子名称: | 4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | 著者 | Grazulis, S, Manakova, E, Tamulaitiene, G. | 登録日 | 2011-05-31 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51, 2012
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3S9T
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![BU of 3s9t by Molmil](/molmil-images/mine/3s9t) | Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide | 分子名称: | 2-chloro-5-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | 著者 | Grazulis, S, Manakova, E, Tamulaitiene, G. | 登録日 | 2011-06-02 | 公開日 | 2012-04-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51, 2012
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3V21
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![BU of 3v21 by Molmil](/molmil-images/mine/3v21) | Crystal structure of Type IIF restriction endonuclease Bse634I with cognate DNA | 分子名称: | DNA (5'-D(*TP*TP*CP*GP*AP*CP*CP*GP*GP*TP*CP*GP*A)-3'), Endonuclease Bse634IR | 著者 | Manakova, E.N, Grazulis, S, Golovenko, D, Tamulaitiene, G. | 登録日 | 2011-12-11 | 公開日 | 2012-04-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural mechanisms of the degenerate sequence recognition by Bse634I restriction endonuclease. Nucleic Acids Res., 40, 2012
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3SBI
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![BU of 3sbi by Molmil](/molmil-images/mine/3sbi) | Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide | 分子名称: | 4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | 著者 | Grazulis, S, Manakova, E, Tamulaitiene, G. | 登録日 | 2011-06-05 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51, 2012
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3V1Z
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![BU of 3v1z by Molmil](/molmil-images/mine/3v1z) | Crystal structure of Type IIF restriction endonuclease Bse634I with cognate DNA | 分子名称: | DNA (5'-D(*TP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*CP*G)-3'), Endonuclease Bse634IR | 著者 | Manakova, E.N, Grazulis, S, Golovenko, D, Tamulaitiene, G. | 登録日 | 2011-12-11 | 公開日 | 2012-04-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural mechanisms of the degenerate sequence recognition by Bse634I restriction endonuclease. Nucleic Acids Res., 40, 2012
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3V20
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![BU of 3v20 by Molmil](/molmil-images/mine/3v20) | Crystal structure of Type IIF restriction endonuclease Bse634I with cognate DNA | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Manakova, E.N, Grazulis, S, Golovenko, D, Tamulaitiene, G. | 登録日 | 2011-12-11 | 公開日 | 2012-04-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural mechanisms of the degenerate sequence recognition by Bse634I restriction endonuclease. Nucleic Acids Res., 40, 2012
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