3SAX

Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide

Summary for 3SAX

Entry DOI	10.2210/pdb3sax/pdb
Related	3S8X 3S9T 3SAP 3SBH 3SBI
Descriptor	Carbonic anhydrase 2, ZINC ION, 2-chloro-5-{[(5-ethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, ... (6 entities in total)
Functional Keywords	drug design, sulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30045.77
Authors	Grazulis, S.,Manakova, E.,Tamulaitiene, G. (deposition date: 2011-06-03, release date: 2012-04-11, Last modification date: 2023-09-13)
Primary citation	Capkauskaite, E.,Zubriene, A.,Baranauskiene, L.,Tamulaitiene, G.,Manakova, E.,Kairys, V.,Grazulis, S.,Tumkevicius, S.,Matulis, D. Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51:259-270, 2012 Cited by PubMed: 22440859 DOI: 10.1016/j.ejmech.2012.02.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation