5EGQ
 
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5UWK
 | | Matrix metalloproteinase-13 complexed with selective inhibitor compound (S)-10a | | Descriptor: | (S)-3-methyl-2-(4'-(((4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)thio)methyl)-[1,1'-biphenyl]-4-ylsulfonamido)butanoic acid, CALCIUM ION, Collagenase 3, ... | | Authors: | Taylor, A.B, Cao, X, Hart, P.J. | | Deposit date: | 2017-02-21 | | Release date: | 2017-07-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.
J. Med. Chem., 60, 2017
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5UWM
 | | Matrix metalloproteinase-13 complexed with selective inhibitor compound (R)-17a | | Descriptor: | (R)-N-(3-methyl-1-(methylamino)-1-oxobutan-2-yl)-5-(4-(((4-oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)thio)methyl)phenyl)furan-2-carboxamide, CALCIUM ION, Collagenase 3, ... | | Authors: | Taylor, A.B, Cao, X, Hart, P.J. | | Deposit date: | 2017-02-21 | | Release date: | 2017-07-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.
J. Med. Chem., 60, 2017
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5VFE
 | | Synaptotagmin 1 C2A domain, lead-bound | | Descriptor: | LEAD (II) ION, SULFATE ION, Synaptotagmin-1 | | Authors: | Taylor, A.B, Hart, P.J, Igumenova, T.I. | | Deposit date: | 2017-04-07 | | Release date: | 2018-04-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | High affinity interactions of Pb2+with synaptotagmin I.
Metallomics, 10, 2018
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4OTC
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5VFF
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4OTA
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5VFG
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4OTB
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5TIX
 | | Schistosoma haematobium (Blood Fluke) Sulfotransferase/R-oxamniquine Complex | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase, {(2R)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol | | Authors: | Taylor, A.B, Hart, P.J. | | Deposit date: | 2016-10-03 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
J. Biol. Chem., 292, 2017
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5TIV
 | | Schistosoma haematobium (Blood Fluke) Sulfotransferase | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase | | Authors: | Taylor, A.B, Hart, P.J. | | Deposit date: | 2016-10-03 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
J. Biol. Chem., 292, 2017
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5TIY
 | | Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol | | Authors: | Taylor, A.B, Hart, P.J. | | Deposit date: | 2016-10-03 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
J. Biol. Chem., 292, 2017
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5TIZ
 | | Schistosoma japonicum (Blood Fluke) Sulfotransferase | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase | | Authors: | Taylor, A.B, Hart, P.J. | | Deposit date: | 2016-10-03 | | Release date: | 2017-05-31 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
J. Biol. Chem., 292, 2017
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8E5Q
 | | Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0150303 Complex | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein, [2-(dihydroxyamino)-4-({[(3R)-1-[(1H-indol-3-yl)methyl]-3-{[3-(trifluoromethyl)phenyl]methyl}pyrrolidin-3-yl]methyl}amino)phenyl]methanol | | Authors: | Taylor, A.B, Alwan, S.N. | | Deposit date: | 2022-08-22 | | Release date: | 2023-07-26 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.
Plos Pathog., 19, 2023
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8E5R
 | | Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0150610 Complex | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein, [4-({[(3R)-1-[(1H-indol-3-yl)methyl]-3-{[4-(trifluoromethyl)phenyl]methyl}pyrrolidin-3-yl]methyl}amino)-3-nitrophenyl]methanol | | Authors: | Taylor, A.B, Alwan, S.N. | | Deposit date: | 2022-08-22 | | Release date: | 2023-07-26 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.
Plos Pathog., 19, 2023
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4ECH
 | | Yeast Polyamine Oxidase FMS1, H67Q Mutant | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Polyamine oxidase FMS1 | | Authors: | Taylor, A.B, Adachi, M.S, Hart, P.J, Fitzpatrick, P.F. | | Deposit date: | 2012-03-26 | | Release date: | 2012-06-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mechanistic and structural analyses of the role of his67 in the yeast polyamine oxidase fms1.
Biochemistry, 51, 2012
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2H0R
 | | Structure of the Yeast Nicotinamidase Pnc1p | | Descriptor: | Nicotinamidase, ZINC ION | | Authors: | Taylor, A.B, Hu, G, Hart, P.J, McAlister-Henn, L. | | Deposit date: | 2006-05-15 | | Release date: | 2007-03-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of the yeast nicotinamidase Pnc1p.
Arch.Biochem.Biophys., 461, 2007
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3BBD
 | | M. jannaschii Nep1 complexed with S-adenosyl-homocysteine | | Descriptor: | GLYCEROL, Ribosome biogenesis protein NEP1-like, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Taylor, A.B, Meyer, B, Leal, B.Z, Kotter, P, Hart, P.J, Entian, K.-D, Wohnert, J. | | Deposit date: | 2007-11-09 | | Release date: | 2008-02-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site.
Nucleic Acids Res., 36, 2008
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3BBE
 | | M. jannaschii Nep1 | | Descriptor: | GLYCEROL, Ribosome biogenesis protein NEP1-like | | Authors: | Taylor, A.B, Meyer, B, Leal, B.Z, Kotter, P, Hart, P.J, Entian, K.-D, Wohnert, J. | | Deposit date: | 2007-11-09 | | Release date: | 2008-02-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site.
Nucleic Acids Res., 36, 2008
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3BBH
 | | M. jannaschii Nep1 complexed with Sinefungin | | Descriptor: | GLYCEROL, Ribosome biogenesis protein NEP1-like, SINEFUNGIN | | Authors: | Taylor, A.B, Meyer, B, Leal, B.Z, Kotter, P, Hart, P.J, Entian, K.-D, Wohnert, J. | | Deposit date: | 2007-11-09 | | Release date: | 2008-02-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site.
Nucleic Acids Res., 36, 2008
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1NWA
 | | Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-bound Methionine | | Descriptor: | Peptide methionine sulfoxide reductase msrA | | Authors: | Taylor, A.B, Benglis Jr, D.M, Dhandayuthapani, S, Hart, P.J, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2003-02-05 | | Release date: | 2003-07-08 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-bound Methionine
J.Bacteriol., 185, 2003
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1HR8
 | | Yeast Mitochondrial Processing Peptidase beta-E73Q Mutant Complexed with Cytochrome C Oxidase IV Signal Peptide | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CYTOCHROME C OXIDASE POLYPEPTIDE IV, MITOCHONDRIAL PROCESSING PEPTIDASE ALPHA SUBUNIT, ... | | Authors: | Taylor, A.B, Smith, B.S, Kitada, S, Kojima, K, Miyaura, H, Otwinowski, Z, Ito, A, Deisenhofer, J. | | Deposit date: | 2000-12-21 | | Release date: | 2001-07-11 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
Structure, 9, 2001
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1BJP
 | | CRYSTAL STRUCTURE OF 4-OXALOCROTONATE TAUTOMERASE INACTIVATED BY 2-OXO-3-PENTYNOATE AT 2.4 ANGSTROMS RESOLUTION | | Descriptor: | 2-OXO-3-PENTENOIC ACID, 4-OXALOCROTONATE TAUTOMERASE | | Authors: | Taylor, A.B, Czerwinski, R.M, Johnson Junior, W.H, Whitman, C.P, Hackert, M.L. | | Deposit date: | 1998-06-26 | | Release date: | 1998-12-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis.
Biochemistry, 37, 1998
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3BLX
 | | Yeast Isocitrate Dehydrogenase (Apo Form) | | Descriptor: | Isocitrate dehydrogenase [NAD] subunit 1, Isocitrate dehydrogenase [NAD] subunit 2 | | Authors: | Taylor, A.B, Hu, G, Hart, P.J, McAlister-Henn, L. | | Deposit date: | 2007-12-11 | | Release date: | 2008-02-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase.
J.Biol.Chem., 283, 2008
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3RBZ
 | | MthK channel, Ca2+-bound | | Descriptor: | CALCIUM ION, Calcium-gated potassium channel mthK | | Authors: | Taylor, A.B, Parfenova, L.V, Rothberg, B.S. | | Deposit date: | 2011-03-30 | | Release date: | 2011-10-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structures of multiple Ca2+-binding sites in a K+ channel RCK domain
Proc.Natl.Acad.Sci.USA, 2011
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