5UWK

Matrix metalloproteinase-13 complexed with selective inhibitor compound (S)-10a

Summary for 5UWK

Entry DOI	10.2210/pdb5uwk/pdb
Related	5UWL 5UWM 5UWN
Descriptor	Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	metalloproteinase, collagenase, mmp-13, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains	2
Total formula weight	40262.52
Authors	Taylor, A.B.,Cao, X.,Hart, P.J. (deposition date: 2017-02-21, release date: 2017-07-12, Last modification date: 2023-10-04)
Primary citation	Choi, J.Y.,Fuerst, R.,Knapinska, A.M.,Taylor, A.B.,Smith, L.,Cao, X.,Hart, P.J.,Fields, G.B.,Roush, W.R. Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors. J. Med. Chem., 60:5816-5825, 2017 Cited by PubMed: 28653849 DOI: 10.1021/acs.jmedchem.7b00514 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation