5UWM
Matrix metalloproteinase-13 complexed with selective inhibitor compound (R)-17a
Summary for 5UWM
Entry DOI | 10.2210/pdb5uwm/pdb |
Related | 5UWK 5UWL 5UWN |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | metalloproteinase, collagenase, mmp-13, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 4 |
Total formula weight | 41281.67 |
Authors | Taylor, A.B.,Cao, X.,Hart, P.J. (deposition date: 2017-02-21, release date: 2017-07-12, Last modification date: 2023-10-04) |
Primary citation | Choi, J.Y.,Fuerst, R.,Knapinska, A.M.,Taylor, A.B.,Smith, L.,Cao, X.,Hart, P.J.,Fields, G.B.,Roush, W.R. Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors. J. Med. Chem., 60:5816-5825, 2017 Cited by PubMed: 28653849DOI: 10.1021/acs.jmedchem.7b00514 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
Download full validation report