5UWM

Matrix metalloproteinase-13 complexed with selective inhibitor compound (R)-17a

Summary for 5UWM

• Entry DOI: 10.2210/pdb5uwm/pdb
• Related: 5UWK 5UWL 5UWN
• Descriptor: Collagenase 3, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: metalloproteinase, collagenase, mmp-13, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted, extracellular space, extracellular matrix : P45452
• Total number of polymer chains: 4
• Total formula weight: 41281.67

Authors

Taylor, A.B.,Cao, X.,Hart, P.J. (deposition date: 2017-02-21, release date: 2017-07-12, Last modification date: 2023-10-04)

• Primary citation: Choi, J.Y.,Fuerst, R.,Knapinska, A.M.,Taylor, A.B.,Smith, L.,Cao, X.,Hart, P.J.,Fields, G.B.,Roush, W.R.; Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.; J. Med. Chem., 60:5816-5825, 2017; PubMed: 28653849; DOI: 10.1021/acs.jmedchem.7b00514

Experimental method

X-RAY DIFFRACTION (1.62 Å)