4DBU
 
 | | Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid | | Descriptor: | 3-{[4-(trifluoromethyl)phenyl]amino}benzoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Chen, M, Christianson, D.W, Winkler, J.D, Penning, T.M. | | Deposit date: | 2012-01-16 | | Release date: | 2012-03-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.528 Å) | | Cite: | Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorg.Med.Chem.Lett., 22, 2012
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4AZZ
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3UN5
 | | Bacillus cereus phosphopentomutase T85E variant | | Descriptor: | GLYCEROL, MANGANESE (II) ION, Phosphopentomutase | | Authors: | Iverson, T.M, Birmingham, W.R, Panosian, T.D, Nannemann, D.P, Bachmann, B.O. | | Deposit date: | 2011-11-15 | | Release date: | 2012-02-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular Differences between a Mutase and a Phosphatase: Investigations of the Activation Step in Bacillus cereus Phosphopentomutase.
Biochemistry, 51, 2012
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4BK8
 | | Superoxide reductase (Neelaredoxin) from Ignicoccus hospitalis | | Descriptor: | DESULFOFERRODOXIN, FERROUS IRON-BINDING REGION, FE (III) ION | | Authors: | Romao, C.V, Matias, P.M, Pinho, F.G, Sousa, C.M, Barradas, A.R, Pinto, A.F, Teixeira, M, Bandeiras, T.M. | | Deposit date: | 2013-04-22 | | Release date: | 2014-04-02 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.847 Å) | | Cite: | Structure of a Natural Sor Mutant
To be Published
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3V0U
 | | Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding | | Descriptor: | Perakine reductase | | Authors: | Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J. | | Deposit date: | 2011-12-08 | | Release date: | 2012-02-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.203 Å) | | Cite: | Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
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3UN2
 | | Phosphopentomutase T85Q variant enzyme | | Descriptor: | GLYCEROL, MANGANESE (II) ION, Phosphopentomutase | | Authors: | Iverson, T.M, Birmingham, W.R, Panosian, T.D, Nannemann, D.P, Bachmann, B.O. | | Deposit date: | 2011-11-15 | | Release date: | 2012-02-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular Differences between a Mutase and a Phosphatase: Investigations of the Activation Step in Bacillus cereus Phosphopentomutase.
Biochemistry, 51, 2012
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4BOM
 | | Structure of herpesvirus fusion glycoprotein B-bilayer complex revealing the protein-membrane and lateral protein-protein interaction | | Descriptor: | ENVELOPE GLYCOPROTEIN B | | Authors: | Maurer, U.E, Zeev-Ben-Mordehai, Z, Pandurangan, A.P, Cairns, T.M, Hannah, B.P, Whitbeck, J.C, Eisenberg, R.J, Cohen, G.H, Topf, M, Huiskonen, J.T, Grunewald, K. | | Deposit date: | 2013-05-21 | | Release date: | 2013-07-31 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (27 Å) | | Cite: | The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction.
Structure, 21, 2013
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4CH7
 | | Crystal structure of the siroheme decarboxylase NirDL | | Descriptor: | NIRD-LIKE PROTEIN | | Authors: | Schmelz, S, Kriegler, T.M, Haufschildt, K, Layer, G, Heinz, D.W. | | Deposit date: | 2013-11-29 | | Release date: | 2014-07-30 | | Last modified: | 2014-09-10 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | The Crystal Structure of Siroheme Decarboxylase in Complex with Iron-Uroporphyrin III Reveals Two Essential Histidine Residues
J.Mol.Biol., 426, 2014
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4CYJ
 | | Chaetomium thermophilum Pan2:Pan3 complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3-LIKE PROTEIN, ... | | Authors: | Wolf, J, Valkov, E, Allen, M.D, Meineke, B, Gordiyenko, Y, McLaughlin, S.H, Olsen, T.M, Robinson, C.V, Bycroft, M, Stewart, M, Passmore, L.A. | | Deposit date: | 2014-04-11 | | Release date: | 2014-06-11 | | Last modified: | 2014-07-30 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structural Basis for Pan3 Binding to Pan2 and its Function in Mrna Recruitment and Deadenylation
Embo J., 33, 2014
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4C4B
 | | Superoxide reductase (Neelaredoxin) from Archaeoglobus fulgidus E12V in the reduced form | | Descriptor: | 1,2-ETHANEDIOL, FE (II) ION, SUPEROXIDE REDUCTASE | | Authors: | Bandeiras, T.M, Rodrigues, J.V, Sousa, C.M, Barradas, A.R, Pinho, F.G, Pinto, A.F, Teixeira, M, Matias, P.M, Romao, C.V. | | Deposit date: | 2013-09-03 | | Release date: | 2014-07-23 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Understanding the Role of Key Residues in the Superoxide Reductase Molecular Mechanism, Exploring Archaeoglobus Fulgidus Sor Structure
To be Published
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4B1L
 | | CARBOHYDRATE BINDING MODULE CBM66 FROM BACILLUS SUBTILIS | | Descriptor: | LEVANASE, SODIUM ION, beta-D-fructofuranose | | Authors: | Cuskin, F, Flint, J.E, Morland, C, Basle, A, Henrissat, B, Countinho, P.M, Strazzulli, A, Solzehinkin, A, Davies, G.J, Gilbert, H.J, Gloster, T.M. | | Deposit date: | 2012-07-11 | | Release date: | 2012-12-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | How Nature Can Exploit Nonspecific Catalytic and Carbohydrate Binding Modules to Create Enzymatic Specificity
Proc.Natl.Acad.Sci.USA, 109, 2012
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3Q0S
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3Q0Q
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3QPY
 | | Crystal structure of a mutant (K57A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | | Descriptor: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ... | | Authors: | Allison, T.M, Jameson, G.B, Parker, E.J. | | Deposit date: | 2011-02-14 | | Release date: | 2011-04-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochemistry, 50, 2011
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7R2I
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3QGB
 | | Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa | | Descriptor: | 5'-R(*UP*GP*UP*GP*CP*CP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2 | | Authors: | Wang, Y, Qiu, C, Koh, Y.Y, Opperman, L, Gross, L, Hall, T.M.T, Wickens, M. | | Deposit date: | 2011-01-24 | | Release date: | 2011-03-23 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Stacking interactions in PUF-RNA complexes.
Rna, 17, 2011
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3Q0O
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3QR3
 | | Crystal Structure of Cel5A (EG2) from Hypocrea jecorina (Trichoderma reesei) | | Descriptor: | Endoglucanase EG-II, MAGNESIUM ION, SULFATE ION | | Authors: | Lee, T.M, Farrow, M.F, Kaiser, J.T, Arnold, F.H, Mayo, S.L. | | Deposit date: | 2011-02-16 | | Release date: | 2011-11-02 | | Last modified: | 2012-06-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | A structural study of Hypocrea jecorina Cel5A.
Protein Sci., 20, 2011
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3QQ1
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3QSK
 | | 5 Histidine Variant of the anti-RNase A VHH in Complex with RNAse A | | Descriptor: | Engineered 5 Histidine anti-RNase A Camelid VHH Antibody Domain Variant, Ribonuclease pancreatic | | Authors: | Murtaugh, M.L, Fanning, S.W, Sharma, T.M, Terry, A.M, Horn, J.R. | | Deposit date: | 2011-02-21 | | Release date: | 2011-08-10 | | Last modified: | 2011-11-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches.
Protein Sci., 20, 2011
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3QSU
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3RUN
 | | New strategy to analyze structures of glycopeptide antibiotic-target complexes | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Economou, N.J, Townsend, T.M, Loll, P.J. | | Deposit date: | 2011-05-05 | | Release date: | 2012-06-06 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | A carrier protein strategy yields the structure of dalbavancin.
J.Am.Chem.Soc., 134, 2012
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3T9E
 | | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP, 5-(PP)-IP5 (5-IP7) and MgF3 (transition state mimic) | | Descriptor: | (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, ADENOSINE-5'-DIPHOSPHATE, Inositol Pyrophosphate Kinase, ... | | Authors: | Wang, H, Falck, J, Hall, T.M.T, Shears, S.B. | | Deposit date: | 2011-08-02 | | Release date: | 2011-12-07 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
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3SR7
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3T0C
 | | Crystal structure of Streptococcus mutans MetE complexed with Zinc | | Descriptor: | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, SULFATE ION, ZINC ION | | Authors: | Fu, T.M, Liang, Y.H, Su, X.D. | | Deposit date: | 2011-07-19 | | Release date: | 2011-08-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.187 Å) | | Cite: | Crystal Structures of Cobalamin-Independent Methionine Synthase (MetE) from Streptococcus mutans: A Dynamic Zinc-Inversion Model
J.Mol.Biol., 412, 2011
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