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PDB: 118 件
2OAU
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BU of 2oau by Molmil
Mechanosensitive Channel of Small Conductance (MscS)
分子名称: Small-conductance mechanosensitive channel
著者Rees, D.C, Bass, R.B, Steinbacher, S, Strop, P, Barclay, M.T.
登録日2006-12-17
公開日2007-01-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structures of the Prokaryotic Mechanosensitive Channels MscL and MscS
CURRENT TOPICS IN MEMBRANES, 58, 2007
2OAR
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Mechanosensitive Channel of Large Conductance (MscL)
分子名称: GOLD ION, Large-conductance mechanosensitive channel
著者Rees, D.C, Chang, G, Spencer, R.H, Lee, A.T, Steinbacher, S, Strop, P.
登録日2006-12-17
公開日2007-01-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structures of the Prokaryotic Mechanosensitive Channels MscL and MscS
Current Topics in Membranes, 58, 2007
1QRB
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BU of 1qrb by Molmil
PLASTICITY AND STERIC STRAIN IN A PARALLEL BETA-HELIX: RATIONAL MUTATIONS IN P22 TAILSPIKE PROTEIN
分子名称: PROTEIN (TAILSPIKE-PROTEIN)
著者Schuler, B, Furst, F, Osterroth, F, Steinbacher, S, Huber, R, Seckler, R.
登録日1999-06-12
公開日2000-04-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Plasticity and steric strain in a parallel beta-helix: rational mutations in the P22 tailspike protein.
Proteins, 39, 2000
5BYZ
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ERK5 in complex with small molecule
分子名称: 4-({5-fluoro-4-[2-methyl-1-(propan-2-yl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)-N-[2-(piperidin-1-yl)ethyl]benzamide, GLYCEROL, Mitogen-activated protein kinase 7
著者Chen, H, Tucker, J, Wang, X, Gavine, P.R, Philips, C, Augustin, M.A, Schreiner, P, Steinbacher, S, Preston, M, Ogg, D.
登録日2015-06-11
公開日2016-05-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
5BYY
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ERK5 IN COMPLEX WITH SMALL MOLECULE
分子名称: 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Mitogen-activated protein kinase 7
著者Chen, H, Tucker, J, Wang, X, Gavine, P.R, Philips, C, Augustin, M.A, Schreiner, P, Steinbacher, S, Preston, M, Ogg, D.
登録日2015-06-11
公開日2016-05-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
1QRC
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BU of 1qrc by Molmil
TAILSPIKE PROTEIN, MUTANT W391A
分子名称: TAILSPIKE PROTEIN
著者Schuler, B, Furst, F, Osterroth, F, Steinbacher, S, Huber, R, Seckler, R.
登録日1999-06-13
公開日2000-04-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Plasticity and steric strain in a parallel beta-helix: rational mutations in the P22 tailspike protein.
Proteins, 39, 2000
1QQ1
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TAILSPIKE PROTEIN, MUTANT E359G
分子名称: TAILSPIKE PROTEIN
著者Schuler, B, Furst, F, Osterroth, F, Steinbacher, S, Huber, R, Seckler, R.
登録日1999-06-10
公開日2000-04-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Plasticity and steric strain in a parallel beta-helix: rational mutations in the P22 tailspike protein.
Proteins, 39, 2000
7M2G
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INTERLEUKIN-2 (human) mutant P65K, C125S
分子名称: GLYCEROL, Interleukin-2, SULFATE ION
著者Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M.
登録日2021-03-16
公開日2021-08-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Nat Commun, 12, 2021
1QA2
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TAILSPIKE PROTEIN, MUTANT A334V
分子名称: TAILSPIKE PROTEIN
著者Baxa, U, Steinbacher, S, Weintraub, A, Huber, R, Seckler, R.
登録日1999-04-10
公開日2000-01-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity.
J.Mol.Biol., 293, 1999
1QA1
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TAILSPIKE PROTEIN, MUTANT V331G
分子名称: TAILSPIKE PROTEIN
著者Baxa, U, Steinbacher, S, Weintraub, A, Huber, R, Seckler, R.
登録日1999-04-10
公開日2000-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity.
J.Mol.Biol., 293, 1999
1QA3
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TAILSPIKE PROTEIN, MUTANT A334I
分子名称: TAILSPIKE PROTEIN
著者Baxa, U, Steinbacher, S, Weintraub, A, Huber, R, Seckler, R.
登録日1999-04-10
公開日2000-01-12
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mutations improving the folding of phage P22 tailspike protein affect its receptor binding activity.
J.Mol.Biol., 293, 1999
1SP8
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4-Hydroxyphenylpyruvate Dioxygenase
分子名称: 4-Hydroxyphenylpyruvate Dioxygenase, FE (II) ION
著者Fritze, I.M, Linden, L, Freigang, J, Auerbach, G, Huber, R, Steinbacher, S.
登録日2004-03-16
公開日2004-09-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structures of Zea mays and Arabidopsis 4-Hydroxyphenylpyruvate Dioxygenase
Plant physiol., 134, 2004
1SP9
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4-Hydroxyphenylpyruvate Dioxygenase
分子名称: 4-hydroxyphenylpyruvate dioxygenase, FE (II) ION
著者Fritze, I.M, Linden, L, Freigang, J, Auerbach, G, Huber, R, Steinbacher, S.
登録日2004-03-16
公開日2004-09-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The crystal structures of Zea mays and Arabidopsis 4-Hydroxyphenylpyruvate Dioxygenase
Plant Physiol., 134, 2004
1P3Y
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MrsD from Bacillus sp. HIL-Y85/54728
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, MrsD protein
著者Blaesse, M, Kupke, T, Huber, R, Steinbacher, S.
登録日2003-04-19
公開日2003-08-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Structure of MrsD, an FAD-binding protein of the HFCD family.
Acta Crystallogr.,Sect.D, 59, 2003
6AZW
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IDO1/FXB-001116 crystal structure
分子名称: (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide, Indoleamine 2,3-dioxygenase 1
著者Lewis, H.A, Lammens, A, Steinbacher, S.
登録日2017-09-13
公開日2018-03-21
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3LXG
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BU of 3lxg by Molmil
Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3
分子名称: 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine, MAGNESIUM ION, ZINC ION, ...
著者Mosbacher, T, Jestel, A, Steinbacher, S.
登録日2010-02-25
公開日2010-05-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
J.Med.Chem., 53, 2010
4L3P
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BU of 4l3p by Molmil
Crystal Structure of 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine bound to TAK1-TAB1
分子名称: 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine, Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
著者Wang, J, Hornberger, K.R, Crew, A.P, Steinbacher, S, Maskos, K, Moertl, M.
登録日2013-06-06
公開日2013-06-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Bioorg.Med.Chem.Lett., 23, 2013
2XU1
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CATHEPSIN L WITH A NITRILE INHIBITOR
分子名称: (2S,4R)-1-[1-(4-chlorophenyl)cyclopropyl]carbonyl-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide, CATHEPSIN L1
著者Banner, D.W, Benz, J.M, Steinbacher, S, Haap, W.
登録日2010-10-14
公開日2011-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 50, 2011

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