6BHZ
| Trastuzumab Fab D185A (Light Chain) Mutant. | 分子名称: | 1,2-ETHANEDIOL, Trastuzumab Anti-HER2 Fab Heavy Chain, Trastuzumab Anti-HER2 Fab Light Chain D185A | 著者 | DiDonato, M, Spraggon, G. | 登録日 | 2017-10-31 | 公開日 | 2018-02-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation. Chembiochem, 19, 2018
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6BI0
| Trastuzumab Fab N158A, D185A, K190A (Light Chain) Triple Mutant. | 分子名称: | 1,2-ETHANEDIOL, Trastuzumab anti-HER2 Fab Heavy Chain, Trastuzumab anti-HER2 Fab Light Chain | 著者 | DiDonato, M, Spraggon, G. | 登録日 | 2017-10-31 | 公開日 | 2018-02-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.057 Å) | 主引用文献 | Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation. Chembiochem, 19, 2018
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3L4B
| Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima | 分子名称: | ADENOSINE MONOPHOSPHATE, TrkA K+ Channel protein TM1088A, TrkA K+ Channel protein TM1088B, ... | 著者 | Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | 登録日 | 2009-12-18 | 公開日 | 2010-02-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima To be Published
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7RUN
| Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor. | 分子名称: | 1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one, CHLORIDE ION, Proto-oncogene tyrosine-protein kinase receptor Ret | 著者 | Lee, C.C, Spraggon, G. | 登録日 | 2021-08-17 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.51 Å) | 主引用文献 | Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- d ]pyrimidine RET Inhibitors. Acs Med.Chem.Lett., 12, 2021
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4BIH
| Crystal structure of the conserved staphylococcal antigen 1A, Csa1A | 分子名称: | CALCIUM ION, UNCHARACTERIZED LIPOPROTEIN SAOUHSC_00053 | 著者 | Malito, E, Bottomley, M.J, Spraggon, G, Schluepen, C, Liberatori, S. | 登録日 | 2013-04-10 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.459 Å) | 主引用文献 | Mining the Bacterial Unknown Proteome: Identification and Characterization of a Novel Family of Highly Conserved Protective Antigens in Staphylococcus Aureus Biochem.J., 455, 2013
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4B8Y
| Ferrichrome-bound FhuD2 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | 著者 | Malito, E, Bottomley, M.J, Spraggon, G. | 登録日 | 2012-08-31 | 公開日 | 2012-11-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Functional Characterization of the Staphylococcus Aureus Virulence Factor and Vaccine Candidate Fhud2. Biochem.J., 449, 2013
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3FCA
| Genetic Incorporation of a Metal-ion Chelating Amino Acid into proteins as biophysical probe | 分子名称: | Cysteine synthase, ZINC ION | 著者 | Wang, F, Lee, H, Spraggon, G, Schultz, P.G. | 登録日 | 2008-11-21 | 公開日 | 2009-02-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.149 Å) | 主引用文献 | Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe. J.Am.Chem.Soc., 131, 2009
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3JXO
| Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima | 分子名称: | TrkA-N domain protein | 著者 | Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | 登録日 | 2009-09-20 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima To be Published
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2QB5
| Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-Kinase (ITPK1) in Complex with ADP and Mn2+ | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, ... | 著者 | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | 登録日 | 2007-06-15 | 公開日 | 2007-07-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Integration of inositol phosphate signaling pathways via human ITPK1. J.Biol.Chem., 282, 2007
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2V9K
| Crystal structure of human PUS10, a novel pseudouridine synthase. | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, GLYCEROL, ... | 著者 | McCleverty, C.J, Hornsby, M, Spraggon, G, Kreusch, A. | 登録日 | 2007-08-23 | 公開日 | 2007-10-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Human Pus10, a Novel Pseudouridine Synthase. J.Mol.Biol., 373, 2007
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2PIS
| Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs | 分子名称: | DNA (5'-D(*CP*GP*(CBR)P*GP*AP*AP*(FFD)P*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION | 著者 | Matsuda, S, Fillo, J.D, Henry, A.A, Wilkins, S.J, Rai, P, Dwyer, T.J, Geierstanger, B.H, Wemmer, D.E, Schultz, P.G, Spraggon, G, Romesberg, F.E. | 登録日 | 2007-04-13 | 公開日 | 2007-10-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs. J.Am.Chem.Soc., 129, 2007
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2Q7D
| Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+ | 分子名称: | Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | 登録日 | 2007-06-06 | 公開日 | 2007-07-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Integration of inositol phosphate signaling pathways via human ITPK1. J.Biol.Chem., 282, 2007
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2QTW
| The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Hampton, E.N, Knuth, M.W, Li, J, Harris, J.L, Lesley, S.A, Spraggon, G. | 登録日 | 2007-08-02 | 公開日 | 2007-09-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2VP8
| Structure of Mycobacterium tuberculosis Rv1207 | 分子名称: | 1,2-ETHANEDIOL, DIHYDROPTEROATE SYNTHASE 2 | 著者 | Gengenbacher, M, Xu, T, Niyomwattanakit, P, Spraggon, G, Dick, T. | 登録日 | 2008-02-27 | 公開日 | 2008-08-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Biochemical and Structural Characterization of the Putative Dihydropteroate Synthase Ortholog Rv1207 of Mycobacterium Tuberculosis. Fems Microbiol.Lett., 287, 2008
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4AE0
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4AE1
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1S96
| The 2.0 A X-ray structure of Guanylate Kinase from E.coli | 分子名称: | Guanylate kinase, PHOSPHATE ION, UNKNOWN ATOM OR ION | 著者 | Kreusch, A, Spraggon, G, Klock, H.E, McMullan, D, Vincent, J, Rodrigues, K, Lesley, S.A. | 登録日 | 2004-02-03 | 公開日 | 2004-02-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Structure of Guanylate Kinase from Escherichia coli at 2.0 A resolution To be Published
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1FZC
| CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH TWO DIFFERENT BOUND LIGANDS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Everse, S.J, Spraggon, G, Veerapandian, L, Riley, M, Doolittle, R.F. | 登録日 | 1998-05-19 | 公開日 | 1998-10-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of fragment double-D from human fibrin with two different bound ligands. Biochemistry, 37, 1998
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2AG6
| Crystal structure of p-bromo-l-phenylalanine-tRNA sythetase in complex with p-bromo-l-phenylalanine | 分子名称: | 4-BROMO-L-PHENYLALANINE, Tyrosyl-tRNA synthetase | 著者 | Turner, J.M, Graziano, J, Spraggon, G, Schultz, P.G. | 登録日 | 2005-07-26 | 公開日 | 2006-04-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural plasticity of an aminoacyl-tRNA synthetase active site Proc.Natl.Acad.Sci.Usa, 103, 2006
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2AQX
| Crystal Structure of the Catalytic and CaM-Binding domains of Inositol 1,4,5-Trisphosphate 3-Kinase B | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PREDICTED: inositol 1,4,5-trisphosphate 3-kinase B | 著者 | Chamberlain, P.P, Sandberg, M.L, Sauer, K, Cooke, M.P, Lesley, S.A, Spraggon, G. | 登録日 | 2005-08-18 | 公開日 | 2005-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B Biochemistry, 44, 2005
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1ZH6
| Crystal Structure of p-acetylphenylalanine-tRNA synthetase in complex with p-acetylphenylalanine | 分子名称: | 4-ACETYL-L-PHENYLALANINE, BETA-MERCAPTOETHANOL, Tyrosyl-tRNA synthetase | 著者 | Turner, J.M, Graziano, J, Spraggon, G, Schultz, P.G. | 登録日 | 2005-04-22 | 公開日 | 2006-04-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase. J.Am.Chem.Soc., 127, 2005
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1ZLT
| Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog | 分子名称: | (4Z)-4-(2-AMINO-5-OXO-3,5-DIHYDRO-4H-IMIDAZOL-4-YLIDENE)-2,3-DICHLORO-4,5,6,7-TETRAHYDROPYRROLO[2,3-C]AZEPIN-8(1H)-ONE, SULFATE ION, Serine/threonine-protein kinase Chk1 | 著者 | Lee, C.C, Ng, K, Wan, Y, Gray, N, Spraggon, G. | 登録日 | 2005-05-09 | 公開日 | 2006-06-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog To be Published
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1ZH0
| Crystal Structure of L-3-(2-napthyl)alanine-tRNA synthetase in complex with L-3-(2-napthyl)alanine | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-(2-NAPHTHYL)-ALANINE, Tyrosyl-tRNA synthetase | 著者 | Turner, J.M, Graziano, J, Spraggon, G, Schultz, P.G. | 登録日 | 2005-04-22 | 公開日 | 2006-04-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural plasticity of an aminoacyl-tRNA synthetase active site Proc.Natl.Acad.Sci.Usa, 103, 2006
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3R5L
| Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Deazaflavin-dependent nitroreductase | 著者 | Cellitti, S.E, Shaffer, J, Jones, D.H, Mukherjee, T, Gurumurthy, M, Bursulaya, B, Boshoff, H.I.M, Choi, I, Nayyar, A, Lee, Y.S, Cherian, J, Niyomrattanakit, P, Dick, T, Manjunatha, U.H, Barry, C.E, Spraggon, G, Geierstanger, B.H. | 登録日 | 2011-03-18 | 公開日 | 2012-01-18 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824. Structure, 20, 2012
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3R5R
| Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420 | 分子名称: | COENZYME F420, Deazaflavin-dependent nitroreductase | 著者 | Cellitti, S.E, Shaffer, J, Jones, D.H, Mukherjee, T, Gurumurthy, M, Bursulaya, B, Boshoff, H.I.M, Choi, I, Nayya, A, Lee, Y.S, Cherian, J, Niyomrattanakit, P, Dick, T, Manjunatha, U.H, Barry, C.E, Spraggon, G, Geierstanger, B.H. | 登録日 | 2011-03-19 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824. Structure, 20, 2012
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