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PDB: 8 件
6WDP
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BU of 6wdp by Molmil
Interleukin 12 receptor subunit beta-1
分子名称: GLYCEROL, Interleukin-12 receptor subunit beta-1, SULFATE ION
著者Spangler, J.B, Thomas, C, Jude, K.M, Garcia, K.C.
登録日2020-04-01
公開日2021-02-24
最終更新日2021-12-01
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell, 184, 2021
4YQX
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BU of 4yqx by Molmil
Mouse IL-2 Bound to JES6-1 scFv Fragment
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-2, JES6-1 VH domain, ...
著者Spangler, J.B, Luca, V.C, Jude, K.M, Garcia, K.C.
登録日2015-03-13
公開日2015-07-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.826 Å)
主引用文献Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Immunity, 42, 2015
4YUE
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BU of 4yue by Molmil
Mouse IL-2 Bound to S4B6 Fab Fragment
分子名称: GLYCEROL, Interleukin-2, S4B6 Fab heavy chain, ...
著者Spangler, J.B, Jude, K.M, Garcia, K.C.
登録日2015-03-18
公開日2015-07-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.194 Å)
主引用文献Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Immunity, 42, 2015
6WDQ
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BU of 6wdq by Molmil
IL23/IL23R/IL12Rb1 signaling complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, ...
著者Jude, K.M, Ely, L.K, Glassman, C.R, Thomas, C, Spangler, J.B, Lupardus, P.J, Garcia, K.C.
登録日2020-04-01
公開日2021-02-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Cell, 184, 2021
8DZ8
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BU of 8dz8 by Molmil
Neoleukin 4, a de novo designed IL-4 mimetic
分子名称: neoleukin-4
著者Jude, K.M, Spangler, J.B, Garcia, K.C.
登録日2022-08-06
公開日2023-03-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.972 Å)
主引用文献Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Nat.Chem.Biol., 19, 2023
6OEL
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BU of 6oel by Molmil
Engineered Fab bound to IL-4 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ...
著者Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C.
登録日2019-03-27
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
J.Biol.Chem., 294, 2019
8SOW
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BU of 8sow by Molmil
Structure of the complex formed by human interleukin-2 and scFv F10
分子名称: F10 single chain fragment variable, Interleukin-2
著者Gould, J.R, Leonard, E.K, Cao, S.D, Spangler, J.B.
登録日2023-04-30
公開日2024-09-04
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
JCI Insight, 2024
8SOZ
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BU of 8soz by Molmil
Structure of the complex formed by human interleukin-2 and scFv 602
分子名称: 602 single chain fragment variable, Interleukin-2
著者Gould, J.R, Leonard, E.K, Cao, S.D, Spangler, J.B.
登録日2023-04-30
公開日2024-09-04
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
JCI Insight, 2024

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件を2024-09-04に公開中

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