1WSX
 
 | | Solution structure of MCL-1 | | 分子名称: | myeloid cell leukemia sequence 1 | | 著者 | Day, C.L, Chen, L, Richardson, S.J, Harrison, P.J, Huang, D.C, Hinds, M.G. | | 登録日 | 2004-11-12 | | 公開日 | 2004-11-23 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
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2BNA
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4QHK
 | | UCA (unbound) from CH103 Lineage | | 分子名称: | UCA heavy chain, UCA light chain | | 著者 | Fera, D, Harrison, S.C. | | 登録日 | 2014-05-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.487 Å) | | 主引用文献 | Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
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1XZX
 | | Thyroxine-Thyroid Hormone Receptor Interactions | | 分子名称: | 3,5,3'TRIIODOTHYRONINE, CACODYLATE ION, Thyroid hormone receptor beta-1 | | 著者 | Sandler, B, Webb, P, Apriletti, J.W, Huber, B.R, Togashi, M, Cunha Lima, S.T, Juric, S, Nilsson, S, Wagner, R, Fletterick, R.J, Baxter, J.D. | | 登録日 | 2004-11-12 | | 公開日 | 2004-12-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Thyroxine-thyroid hormone receptor interactions.
J.Biol.Chem., 279, 2004
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2B7D
 | | Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model | | 分子名称: | (2R)-2-[5-(5-CARBAMIMIDOYL-1H-BENZOIMIDAZOL-2-YL)-6,2'-DIHYDROXY-5'-UREIDOMETHYL-BIPHENYL-3-YL]-SUCCINIC ACID, Coagulation factor VII, Tissue factor | | 著者 | Young, W.B, Mordenti, J, Torkelson, S, Shrader, W.D, Kolesnikov, A, Rai, R, Liu, L, Hu, H, Leahy, E.M, Green, M.J, Sprengeler, P.A, Katz, B.A, Yu, C, Janc, J.W, Elrod, K.C, Marzec, U.M, Hanson, S.R. | | 登録日 | 2005-10-04 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.
Bioorg.Med.Chem.Lett., 16, 2006
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3IRD
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5WHM
 | | Crystal Structure of IclR Family Transcriptional Regulator from Brucella abortus | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ... | | 著者 | Kim, Y, Wu, R, Tesar, C, Endres, M, Babnigg, G, Crosson, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2017-07-17 | | 公開日 | 2017-08-23 | | 最終更新日 | 2019-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Molecular control of gene expression byBrucellaBaaR, an IclR-type transcriptional repressor.
J. Biol. Chem., 293, 2018
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2Z74
 | | T. tengcongensis glmS ribozyme bound to glucose-6-phosphate | | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, glmS ribozyme RNA, ... | | 著者 | Klein, D.J, Wilkinson, S.R, Been, M.D, Ferre-D'Amare, A.R. | | 登録日 | 2007-08-15 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme
J.Mol.Biol., 373, 2007
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5UC0
 | | Crystal Structure of Beta-barrel-like, Uncharacterized Protein of COG5400 from Brucella abortus | | 分子名称: | CHLORIDE ION, PENTAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Kim, Y, Bigelow, L, Endres, M, Babnigg, G, Crosson, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2016-12-21 | | 公開日 | 2017-02-08 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus.
Mol. Microbiol., 2018
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4QHL
 | | I3.2 (unbound) from CH103 Lineage | | 分子名称: | I3 heavy chain, UCA light chain | | 著者 | Fera, D, Harrison, S.C. | | 登録日 | 2014-05-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.153 Å) | | 主引用文献 | Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
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1Y0X
 | | Thyroxine-Thyroid Hormone Receptor Interactions | | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, CACODYLATE ION, Thyroid hormone receptor beta-1 | | 著者 | Sandler, B, Webb, P, Apriletti, J.W, Huber, B.R, Togashi, M, Cunha Lima, S.T, Juric, S, Nilsson, S, Wagner, R, Fletterick, R.J, Baxter, J.D. | | 登録日 | 2004-11-16 | | 公開日 | 2004-12-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Thyroxine-thyroid hormone receptor interactions.
J.Biol.Chem., 279, 2004
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4QHN
 | | I2 (unbound) from CH103 Lineage | | 分子名称: | I2 heavy chain, I2 light chain | | 著者 | Fera, D, Harrison, S.C. | | 登録日 | 2014-05-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4PJ3
 | | Structural insight into the function and evolution of the spliceosomal helicase Aquarius, Structure of Aquarius in complex with AMPPNP | | 分子名称: | Intron-binding protein aquarius, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | De, I, Bessonov, S, Hofele, R, dos Santos, K.F, Will, C.L, Urlaub, H, Luhrmann, R, Pena, V. | | 登録日 | 2014-05-11 | | 公開日 | 2015-01-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.
Nat.Struct.Mol.Biol., 22, 2015
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1UWF
 | | 1.7 A resolution structure of the receptor binding domain of the FimH adhesin from uropathogenic E. coli | | 分子名称: | FIMH PROTEIN, GLYCEROL, butyl alpha-D-mannopyranoside | | 著者 | Bouckaert, J, Berglund, J, Genst, E.D, Cools, L, Hung, C.-S, Wuhrer, M, Zavialov, A, Langermann, S, Hultgren, S, Wyns, L, Oscarson, S, Knight, S.D, De Greve, H. | | 登録日 | 2004-02-05 | | 公開日 | 2005-02-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Receptor Binding Studies Disclose a Novel Class of High-Affinity Inhibitors of the Escherichia Coli Fimh Adhesin.
Mol.Microbiol., 55, 2005
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4QHM
 | | I3.1 (unbound) from CH103 Lineage | | 分子名称: | I2 light chain, I3 heavy chain | | 著者 | Fera, D, Harrison, S.C. | | 登録日 | 2014-05-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | | 主引用文献 | Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3EYO
 | | Crystal structure of anti-human cytomegalovirus antibody 8F9 | | 分子名称: | 8f9 Fab, AD-2 | | 著者 | Thomson, C.A, Bryson, S, McLean, G.R, Creagh, A.L, Pai, E.F, Schrader, J.W. | | 登録日 | 2008-10-21 | | 公開日 | 2008-12-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus.
Embo J., 27, 2008
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3F12
 | | Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus | | 分子名称: | 8f9 Fab, M2J1 Fab | | 著者 | Thomson, C.A, Bryson, S, McLean, G.R, Creagh, A.L, Pai, E.F, Schrader, J.W. | | 登録日 | 2008-10-27 | | 公開日 | 2009-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus.
Embo J., 27, 2008
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1FVV
 | | THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR | | 分子名称: | 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE, CYCLIN A, CYCLIN-DEPENDENT KINASE 2 | | 著者 | Davis, S.T, Benson, B.G, Bramson, H.N, Chapman, D.E, Dickerson, S.H, Dold, K.M, Eberwein, D.J, Edelstein, M, Frye, S.V, Gampe Jr, R.T, Griffin, R.J, Harris, P.A, Hassell, A.M, Holmes, W.D, Hunter, R.N, Knick, V.B, Lackey, K, Lovejoy, B, Luzzio, M.J, Murray, D, Parker, P, Rocque, W.J, Shewchuk, L, Veal, J.M, Walker, D.H, Kuyper, L.K. | | 登録日 | 2000-09-20 | | 公開日 | 2001-01-17 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291, 2001
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2Z75
 | | T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate | | 分子名称: | 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, glmS ribozyme RNA, ... | | 著者 | Klein, D.J, Wilkinson, S.R, Been, M.D, Ferre-D'Amare, A.R. | | 登録日 | 2007-08-15 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme
J.Mol.Biol., 373, 2007
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4QPK
 | | 1.7 Angstrom Structure of a Bacterial Phosphotransferase | | 分子名称: | GLYCEROL, PHOSPHATE ION, PHOSPHOTRANSFERASE, ... | | 著者 | Willett, J.W, Crosson, S, Herrou, J. | | 登録日 | 2014-06-23 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4IRX
 | | Crystal structure of Caulobacter myo-inositol binding protein bound to myo-inositol | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, Sugar ABC transporter, periplasmic sugar-binding protein | | 著者 | Herrou, J, Crosson, S. | | 登録日 | 2013-01-15 | | 公開日 | 2013-03-20 | | 最終更新日 | 2016-03-30 | | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | | 主引用文献 | myo-inositol and D-ribose ligand discrimination in an ABC periplasmic binding protein.
J.Bacteriol., 195, 2013
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3OXH
 | | Mycobacterium tuberculosis kinase inhibitor homolog RV0577 | | 分子名称: | CHLORIDE ION, PARA-MERCURY-BENZENESULFONIC ACID, RV0577 PROTEIN, ... | | 著者 | Echols, N, Flynn, E.M, Stephenson, S, Ng, H.-L, Alber, T, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2010-09-21 | | 公開日 | 2011-10-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA.
Biochemistry, 2017
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4FA3
 | | Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (R)-1-(naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid (86) | | 分子名称: | (3R)-1-(naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, ACETATE ION, ... | | 著者 | Turnbull, A.P, Jamieson, S.M.F, Brooke, D.G, Heinrich, D, Atwell, G.J, Silva, S, Hamilton, E.J, Rigoreau, L.J.M, Trivier, E, Soudy, C, Samlal, S.S, Owen, P.J, Schroeder, E, Raynham, T, Flanagan, J.U, Denny, W.A. | | 登録日 | 2012-05-21 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3
J.Med.Chem., 55, 2012
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1XCQ
 | | Complex HCV core-Fab 19D9D6-Protein L mutant (D55A,L57H,Y64W) in space group P21 | | 分子名称: | Capsid protein C, Monoclonal antibody 19D9D6 Heavy chain, Monoclonal antibody 19D9D6 Light chain, ... | | 著者 | Menez, R, Housden, N.G, Harrison, S, Jolivet-Reynaud, C, Gore, M.G, Stura, E.A. | | 登録日 | 2004-09-03 | | 公開日 | 2005-05-31 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Different crystal packing in Fab-protein L semi-disordered peptide complex.
Acta Crystallogr.,Sect.D, 61, 2005
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4FAL
 | | Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-N-methylbenzamide (80) | | 分子名称: | 1,2-ETHANEDIOL, 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-methylbenzamide, Aldo-keto reductase family 1 member C3, ... | | 著者 | Turnbull, A.P, Jamieson, S.M.F, Brooke, D.G, Heinrich, D, Atwell, G.J, Silva, S, Hamilton, E.J, Rigoreau, L.J.M, Trivier, E, Soudy, C, Samlal, S.S, Owen, P.J, Schroeder, E, Raynham, T, Flanagan, J.U, Denny, W.A. | | 登録日 | 2012-05-22 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3
J.Med.Chem., 55, 2012
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