6RYL
 
 | | WUS-HD bound to TAAT DNA | | Descriptor: | DNA (5'-D(P*CP*AP*CP*AP*AP*CP*CP*CP*AP*TP*TP*AP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*TP*AP*AP*TP*GP*GP*GP*TP*TP*GP*TP*G)-3'), Protein WUSCHEL | | Authors: | Sloan, J.J, Wild, K, Sinning, I. | | Deposit date: | 2019-06-10 | | Release date: | 2020-04-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL.
Nat Commun, 11, 2020
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8ODU
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (amphipol) | | Descriptor: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | Authors: | McDowell, M.A, Wild, K, Sinning, I. | | Deposit date: | 2023-03-09 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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8ODV
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (nanodisc) | | Descriptor: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | Authors: | McDowell, M.A, Wild, K, Sinning, I. | | Deposit date: | 2023-03-09 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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4UE4
 | | Structural basis for targeting and elongation arrest of Bacillus signal recognition particle | | Descriptor: | 6S RNA, FTSQ SIGNAL SEQUENCE, SIGNAL RECOGNITION PARTICLE PROTEIN | | Authors: | Beckert, B, Kedrov, A, Sohmen, D, Kempf, G, Wild, K, Sinning, I, Stahlberg, H, Wilson, D.N, Beckmann, R. | | Deposit date: | 2014-12-15 | | Release date: | 2015-09-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Translational Arrest by a Prokaryotic Signal Recognition Particle is Mediated by RNA Interactions.
Nat.Struct.Mol.Biol., 22, 2015
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1Y10
 | | Mycobacterial adenylyl cyclase Rv1264, holoenzyme, inhibited state | | Descriptor: | CALCIUM ION, Hypothetical protein Rv1264/MT1302, PENTAETHYLENE GLYCOL | | Authors: | Tews, I, Findeisen, F, Sinning, I, Schultz, A, Schultz, J.E, Linder, J.U. | | Deposit date: | 2004-11-16 | | Release date: | 2005-05-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
Science, 308, 2005
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1Y11
 | | Mycobacterial adenylyl cyclase Rv1264, holoenzyme, active state | | Descriptor: | GLYCEROL, Hypothetical protein Rv1264/MT1302, PENTAETHYLENE GLYCOL, ... | | Authors: | Tews, I, Findeisen, F, Sinning, I, Schultz, A, Schultz, J.E, Linder, J.U. | | Deposit date: | 2004-11-16 | | Release date: | 2005-05-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
Science, 308, 2005
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2ABW
 | | Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis) | | Descriptor: | Pdx2 protein, TETRAETHYLENE GLYCOL | | Authors: | Gengenbacher, M, Fitzpatrick, T.B, Raschle, T, Flicker, K, Sinning, I, Mueller, S, Macheroux, P, Tews, I, Kappes, B. | | Deposit date: | 2005-07-17 | | Release date: | 2006-01-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Vitamin B6 Biosynthesis by the Malaria Parasite Plasmodium falciparum: Biochemical and structural insights
J.Biol.Chem., 281, 2006
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5TKY
 | | Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein | | Authors: | Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. | | Deposit date: | 2016-10-10 | | Release date: | 2016-11-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.
Nat Commun, 7, 2016
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7Q72
 | | Structure of Pla1 in complex with Red1 | | Descriptor: | NURS complex subunit red1, Poly(A) polymerase pla1 | | Authors: | Soni, K, Wild, K, Sinning, I. | | Deposit date: | 2021-11-09 | | Release date: | 2022-12-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Nat Commun, 14, 2023
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1SMB
 | | Crystal Structure of Golgi-Associated PR-1 protein | | Descriptor: | 17kD fetal brain protein | | Authors: | Serrano, R.L, Kuhn, A, Hendricks, A, Helms, J.B, Sinning, I, Groves, M.R. | | Deposit date: | 2004-03-08 | | Release date: | 2004-09-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism
J.Mol.Biol., 339, 2004
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7OJU
 | | Chaetomium thermophilum Naa50 GNAT-domain in complex with bisubstrate analogue CoA-Ac-MVNAL | | Descriptor: | CARBOXYMETHYL COENZYME *A, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | Weidenhausen, J, Kopp, J, Sinning, I. | | Deposit date: | 2021-05-17 | | Release date: | 2022-09-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
Int J Mol Sci, 23, 2022
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3MIX
 | | Crystal structure of the cytosolic domain of B. subtilis FlhA | | Descriptor: | Flagellar biosynthesis protein flhA | | Authors: | Bange, G, Kuemmerer, N, Bozkurt, G, Wild, K, Sinning, I. | | Deposit date: | 2010-04-12 | | Release date: | 2010-06-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system.
Proc.Natl.Acad.Sci.USA, 107, 2010
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8OO0
 | | Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S0, ... | | Authors: | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | | Deposit date: | 2023-04-04 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Nat Commun, 15, 2024
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8ONX
 | | High resolution structure of Chaetomium thermophilum MAP2 | | Descriptor: | MANGANESE (II) ION, Methionine aminopeptidase 2 | | Authors: | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | | Deposit date: | 2023-04-04 | | Release date: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Nat Commun, 15, 2024
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8ONY
 | | Human Methionine Aminopeptidase 2 at the 80S ribosome | | Descriptor: | 28S rRNA, 5.8S rRNA, 60S ribosomal protein L19, ... | | Authors: | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | | Deposit date: | 2023-04-04 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Nat Commun, 15, 2024
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8ONZ
 | | Chaetomium thermophilum Methionine Aminopeptidase 2 at the 80S ribosome | | Descriptor: | 28S rRNA, 5.8S rRNA, 60S ribosomal protein L25-like protein, ... | | Authors: | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | | Deposit date: | 2023-04-04 | | Release date: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Nat Commun, 15, 2024
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4NWB
 | | Crystal structure of Mrt4 | | Descriptor: | SULFATE ION, mRNA turnover protein 4 | | Authors: | Holdermann, I, Sinning, I. | | Deposit date: | 2013-12-06 | | Release date: | 2014-03-26 | | Last modified: | 2014-04-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | 60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Nat Commun, 5, 2014
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4IPA
 | | Structure of a thermophilic Arx1 | | Descriptor: | Putative curved DNA-binding protein, SULFATE ION | | Authors: | Bange, G, Sinning, I. | | Deposit date: | 2013-01-09 | | Release date: | 2013-01-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Consistent mutational paths predict eukaryotic thermostability.
BMC Evol Biol, 13, 2013
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5NZT
 | | The structure of the COPI coat linkage I | | Descriptor: | ADP-ribosylation factor 1, Coatomer subunit alpha, Coatomer subunit beta, ... | | Authors: | Dodonova, S.O, Aderhold, P, Kopp, J, Ganeva, I, Roehling, S, Hagen, W.J.H, Sinning, I, Wieland, F, Briggs, J.A.G. | | Deposit date: | 2017-05-15 | | Release date: | 2017-06-28 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (17 Å) | | Cite: | 9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.
Elife, 6, 2017
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5NZV
 | | The structure of the COPI coat linkage IV | | Descriptor: | ADP-ribosylation factor 1, Coatomer subunit alpha, Coatomer subunit beta, ... | | Authors: | Dodonova, S.O, Aderhold, P, Kopp, J, Ganeva, I, Roehling, S, Hagen, W.J.H, Sinning, I, Wieland, F, Briggs, J.A.G. | | Deposit date: | 2017-05-15 | | Release date: | 2017-06-28 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (17.299999 Å) | | Cite: | 9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.
Elife, 6, 2017
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5EM2
 | | Crystal structure of the Erb1-Ytm1 complex | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Ribosome biogenesis protein ERB1, ... | | Authors: | Ahmed, Y.L, Sinning, I. | | Deposit date: | 2015-11-05 | | Release date: | 2015-12-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Concerted removal of the Erb1-Ytm1 complex in ribosome biogenesis relies on an elaborate interface.
Nucleic Acids Res., 44, 2016
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5NZU
 | | The structure of the COPI coat linkage II | | Descriptor: | ADP-ribosylation factor 1, Coatomer subunit alpha, Coatomer subunit beta, ... | | Authors: | Dodonova, S.O, Aderhold, P, Kopp, J, Ganeva, I, Roehling, S, Hagen, W.J.H, Sinning, I, Wieland, F, Briggs, J.A.G. | | Deposit date: | 2017-05-15 | | Release date: | 2017-06-28 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (15 Å) | | Cite: | 9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.
Elife, 6, 2017
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5E4W
 | | Crystal structure of cpSRP43 chromodomains 2 and 3 in complex with the Alb3 tail | | Descriptor: | CALCIUM ION, GLYCEROL, Inner membrane protein ALBINO3, ... | | Authors: | Horn, A, Ahmed, Y.L, Wild, K, Sinning, I. | | Deposit date: | 2015-10-07 | | Release date: | 2015-12-02 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.
Nat Commun, 6, 2015
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4GNI
 | | Structure of the Ssz1 ATPase bound to ATP and Magnesium | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein | | Authors: | Bange, G, Sinning, I. | | Deposit date: | 2012-08-17 | | Release date: | 2012-12-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.796 Å) | | Cite: | Structural characterization of a eukaryotic chaperone-the ribosome-associated complex.
Nat.Struct.Mol.Biol., 20, 2013
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1J8Y
 | | Signal Recognition Particle conserved GTPase domain from A. ambivalens T112A mutant | | Descriptor: | SIGNAL RECOGNITION 54 KDA PROTEIN | | Authors: | Montoya, G, te Kaat, K, Moll, R, Schaerfer, G, Sinning, I. | | Deposit date: | 2001-05-23 | | Release date: | 2001-06-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP-SRP receptor complex.
Structure Fold.Des., 8, 2000
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