8I8Z
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5H0B
| Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoic acid | 分子名称: | (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate, Tyrosine-protein kinase HCK | 著者 | Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. | 登録日 | 2016-10-04 | 公開日 | 2017-10-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
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1IVO
| Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal Growth Factor Receptor, ... | 著者 | Ogiso, H, Ishitani, R, Nureki, O, Fukai, S, Yamanaka, M, Kim, J.H, Saito, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-03-28 | 公開日 | 2002-10-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains. Cell(Cambridge,Mass.), 110, 2002
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1J1H
| Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus | 分子名称: | Small Protein B | 著者 | Someya, T, Nameki, N, Hosoi, H, Suzuki, S, Hatanaka, H, Fujii, M, Terada, T, Shirouzu, M, Inoue, Y, Shibata, T, Kuramitsu, S, Yokoyama, S, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-12-04 | 公開日 | 2003-02-11 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus FEBS Lett., 535, 2003
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1IUH
| Crystal structure of TT0787 of thermus thermophilus HB8 | 分子名称: | 2'-5' RNA Ligase | 著者 | Kato, M, Sakai, H, Shirouzu, M, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-03-05 | 公開日 | 2003-06-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of the 2'-5' RNA Ligase from Thermus thermophilus HB8 J.MOL.BIOL., 329, 2003
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1J03
| Solution structure of a putative steroid-binding protein from Arabidopsis | 分子名称: | putative steroid binding protein | 著者 | Suzuki, S, Hatanaka, H, Kigawa, T, Terada, T, Shirouzu, M, Seki, M, Shinozaki, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-10-29 | 公開日 | 2003-12-16 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of an Arabidopsis homologue of the mammalian membrane-associated progesterone receptor To be Published
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7DPA
| Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex | 分子名称: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | 著者 | Kukimoto-Niino, M, Katsura, K, Kaushik, R, Ehara, H, Yokoyama, T, Uchikubo-Kamo, T, Mishima-Tsumagari, C, Yonemochi, M, Ikeda, M, Hanada, K, Zhang, K.Y.J, Shirouzu, M. | 登録日 | 2020-12-18 | 公開日 | 2021-08-04 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex. Sci Adv, 7, 2021
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8IP9
| Wheat 40S ribosome in complex with a tRNAi | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S23, 40S ribosomal protein eS1, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
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8IPA
| Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide | 分子名称: | 18S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, 40S ribosomal protein eL8, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
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8IPB
| Wheat 80S ribosome pausing on AUG-Stop with cycloheximide | 分子名称: | 18S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, 40S ribosomal protein eL8, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
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1VDY
| NMR Structure of the hypothetical ENTH-VHS domain At3g16270 from Arabidopsis thaliana | 分子名称: | hypothetical protein (RAFL09-17-B18) | 著者 | Lopez-Mendez, B, Pantoja-Uceda, D, Tomizawa, T, Koshiba, S, Kigawa, T, Shirouzu, M, Terada, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Seki, M, Shinozaki, K, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-03-25 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the hypothetical ENTH-VHS domain AT3G16270 from arabidopsis thaliana To be Published
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8IP8
| Wheat 80S ribosome stalled on AUG-Stop boron dependently | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein eL8, 40S ribosomal protein eS1, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
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6KS0
| Crystal structure of the human adiponectin receptor 1 | 分子名称: | Adiponectin receptor protein 1, PHOSPHATE ION, The heavy chain variable domain (Antibody), ... | 著者 | Tanabe, H, Fujii, Y, Nakamura, Y, Hosaka, T, Okada-Iwabu, M, Iwabu, M, Kimura-Someya, T, Shirouzu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | 登録日 | 2019-08-22 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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6KS1
| Crystal structure of the human adiponectin receptor 2 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | 著者 | Tanabe, H, Fujii, Y, Nakamura, Y, Hosaka, T, Okada-Iwabu, M, Iwabu, M, Kimura-Someya, T, Shirouzu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | 登録日 | 2019-08-22 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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1VEE
| NMR structure of the hypothetical rhodanese domain At4g01050 from Arabidopsis thaliana | 分子名称: | proline-rich protein family | 著者 | Pantoja-Uceda, D, Lopez-Mendez, B, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Seki, M, Shinozaki, K, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-03-30 | 公開日 | 2005-01-25 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the rhodanese homology domain At4g01050(175-295) from Arabidopsis thaliana Protein Sci., 14, 2005
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7EJL
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7EJN
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7EJM
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7E3D
| Crystal structure of human acetylcholinesterase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Acetylcholinesterase | 著者 | Dileep, K.V, Ihara, K, Mishima-Tsumagari, C, Kukimoto-Niino, M, Yonemochi, M, Hanada, K, Shirouzu, M, Zhang, K.Y.J. | 登録日 | 2021-02-08 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery Int.J.Biol.Macromol., 210, 2022
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7E3H
| Crystal structure of human acetylcholinesterase in complex with donepezil | 分子名称: | 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase | 著者 | Dileep, K.V, Ihara, K, Mishima-Tsumagari, C, Kukimoto-Niino, M, Yonemochi, M, Hanada, K, Shirouzu, M, Zhang, K.Y.J. | 登録日 | 2021-02-08 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery Int.J.Biol.Macromol., 210, 2022
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5ZQQ
| Tankyrase-2 in complex with compound 52 | 分子名称: | 1-methyl-1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)spiro[indole-3,4'-piperidin]-2(1H)-one, GLYCEROL, PHOSPHATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-04-19 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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5ZQO
| Tankyrase-2 in complex with compound 1a | 分子名称: | 2-[4-(2-methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, SULFATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-04-19 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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6A84
| Tankyrase-2 in complex with compound 15d | 分子名称: | 2-(4-chloro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, PHOSPHATE ION, ... | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | 登録日 | 2018-07-06 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J. Med. Chem., 62, 2019
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8KCQ
| Solution structures of the N-terminal divergent caplonin homology (NN-CH) domains of human intraflagellar transport protein 54 | 分子名称: | TRAF3-interacting protein 1 | 著者 | Dang, W, Kuwasako, K, He, F, Takahashi, M, Tsuda, K, Nagata, T, Tanaka, A, Kobayashi, N, Kigawa, T, Guentert, P, Shirouzu, M, Yokoyama, S, Muto, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2023-08-08 | 公開日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | 1 H, 13 C, and 15 N resonance assignments and solution structure of the N-terminal divergent calponin homology (NN-CH) domain of human intraflagellar transport protein 54. Biomol.Nmr Assign., 18, 2024
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8K9L
| Full agonist- and positive allosteric modulator-bound mu-type opioid receptor-G protein complex | 分子名称: | (2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine, DAMGO, G protein subunit alpha i3, ... | 著者 | Hisano, T, Uchikubo-Kamo, T, Shirouzu, M, Imai, S, Kaneko, S, Shimada, I. | 登録日 | 2023-08-01 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural and dynamic insights into the activation of the mu-opioid receptor by an allosteric modulator. Nat Commun, 15, 2024
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