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PDB: 16 件
3LY2
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BU of 3ly2 by Molmil
Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
分子名称: 8-(cyclopentyloxy)-4-[(3,5-dichloropyridin-4-yl)amino]-7-methoxy-2H-chromen-2-one, MAGNESIUM ION, SULFATE ION, ...
著者Shiau, A.K, Coyle, A.R, Hsien, J.H, Staszewski, L.M.
登録日2010-02-26
公開日2010-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Water-soluble PDE4 inhibitors for the treatment of dry eye.
Bioorg.Med.Chem.Lett., 20, 2010
5EW9
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BU of 5ew9 by Molmil
Crystal Structure of Aurora A Kinase Domain Bound to MK-5108
分子名称: 4-(3-chloranyl-2-fluoranyl-phenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid, Aurora kinase A
著者Shiau, A.K, Motamedi, A.
登録日2015-11-20
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.181 Å)
主引用文献A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.
Front Oncol, 5, 2015
5I4N
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BU of 5i4n by Molmil
Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Shiau, A.K, Motamedi, A.
登録日2016-02-12
公開日2016-04-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 alpha C helix.
Biochem.J., 473, 2016
4YUR
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BU of 4yur by Molmil
Crystal Structure of Plk4 Kinase Domain Bound to Centrinone
分子名称: 2-({2-fluoro-4-[(2-fluoro-3-nitrobenzyl)sulfonyl]phenyl}sulfanyl)-5-methoxy-N-(3-methyl-1H-pyrazol-5-yl)-6-(morpholin-4-yl)pyrimidin-4-amine, Serine/threonine-protein kinase PLK4
著者Shiau, A.K, Motamedi, A.
登録日2015-03-19
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Science, 348, 2015
1L2I
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BU of 1l2i by Molmil
Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide
分子名称: (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL, CHLORIDE ION, ESTROGEN RECEPTOR, ...
著者Shiau, A.K, Barstad, D, Radek, J.T, Meyers, M.J, Nettles, K.W, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Agard, D.A, Greene, G.L.
登録日2002-02-21
公開日2002-05-01
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nat.Struct.Biol., 9, 2002
3ERD
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BU of 3erd by Molmil
HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH DIETHYLSTILBESTROL AND A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE
分子名称: ACETIC ACID, CHLORIDE ION, DIETHYLSTILBESTROL, ...
著者Shiau, A.K, Barstad, D, Loria, P.M, Cheng, L, Kushner, P.J, Agard, D.A, Greene, G.L.
登録日1999-03-31
公開日1999-04-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Cell(Cambridge,Mass.), 95, 1998
3ERT
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BU of 3ert by Molmil
HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN
分子名称: 4-HYDROXYTAMOXIFEN, PROTEIN (ESTROGEN RECEPTOR ALPHA)
著者Shiau, A.K, Barstad, D, Loria, P.M, Cheng, L, Kushner, P.J, Agard, D.A, Greene, G.L.
登録日1999-03-30
公開日1999-04-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Cell(Cambridge,Mass.), 95, 1998
1L2J
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Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol
分子名称: (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL, ESTROGEN RECEPTOR BETA
著者Shiau, A.K, Barstad, D, Radek, J.T, Meyers, M.J, Nettles, K.W, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Agard, D.A, Greene, G.L.
登録日2002-02-21
公開日2002-05-01
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nat.Struct.Biol., 9, 2002
2IOQ
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BU of 2ioq by Molmil
Crystal Structure of full-length HTPG, the Escherichia coli HSP90
分子名称: Chaperone protein htpG
著者Shiau, A.K, Harris, S.F, Agard, D.A.
登録日2006-10-10
公開日2006-11-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
2IOR
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BU of 2ior by Molmil
Crystal Structure of the N-terminal Domain of HtpG, the Escherichia coli Hsp90, Bound to ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG, HEXANE-1,6-DIOL, ...
著者Shiau, A.K, Harris, S.F, Agard, D.A.
登録日2006-10-10
公開日2006-11-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
2IOP
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BU of 2iop by Molmil
Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG
著者Shiau, A.K, Harris, S.F, Agard, D.A.
登録日2006-10-10
公開日2006-11-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
1BOQ
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BU of 1boq by Molmil
PRO REGION C-TERMINUS: PROTEASE ACTIVE SITE INTERACTIONS ARE CRITICAL IN CATALYZING THE FOLDING OF ALPHA-LYTIC PROTEASE
分子名称: PROTEIN (ALPHA-LYTIC PROTEASE), SULFATE ION
著者Peters, R.J, Shiau, A.K, Sohl, J.L, Anderson, D.E, Tang, G, Silen, J.L, Agard, D.A.
登録日1998-08-05
公開日1998-08-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease.
Biochemistry, 37, 1998
1SF8
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BU of 1sf8 by Molmil
Crystal structure of the carboxy-terminal domain of htpG, the E. coli Hsp90
分子名称: CHLORIDE ION, Chaperone protein htpG, NICKEL (II) ION
著者Harris, S.F, Shiau, A.K, Agard, D.A.
登録日2004-02-19
公開日2004-06-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site.
Structure, 12, 2004
5SZC
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BU of 5szc by Molmil
Structure of human Dpf3 double-PHD domain bound to histone H3 tail peptide with monomethylated K4 and acetylated K14
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Histone H3 tail peptide, ZINC ION, ...
著者Singh, N, Local, A, Shiau, A, Ren, B, Corbett, K.D.
登録日2016-08-13
公開日2017-08-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.193 Å)
主引用文献Identification of H3K4me1-associated proteins at mammalian enhancers.
Nat. Genet., 50, 2018
5SZB
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BU of 5szb by Molmil
Structure of human Dpf3 double-PHD domain bound to histone H3 tail peptide with acetylated K14
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Histone H3 tail peptide, ZINC ION, ...
著者Singh, N, Local, A, Shiau, A, Ren, B, Corbett, K.D.
登録日2016-08-13
公開日2017-08-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Identification of H3K4me1-associated proteins at mammalian enhancers.
Nat. Genet., 50, 2018
2GQ0
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BU of 2gq0 by Molmil
Crystal Structure of the Middle Domain of HtpG, the E. coli Hsp90
分子名称: Chaperone protein htpG
著者Harris, S.F, Shiau, A.K, Agard, D.A.
登録日2006-04-19
公開日2006-10-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006

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件を2024-07-03に公開中

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