4KEP
 
 | | Crystal structure of 4-pyridoxolactonase, wild-type | | 分子名称: | 1,2-ETHANEDIOL, 4-pyridoxolactonase, ACETATE ION, ... | | 著者 | Kobayashi, J, Yoshikane, Y, Baba, S, Mizutani, K, Takahashi, N, Mikami, B, Yagi, T. | | 登録日 | 2013-04-26 | | 公開日 | 2014-04-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure of 4-pyridoxolactonase from Mesorhizobium loti.
Acta Crystallogr.,Sect.F, 70, 2014
|
|
6AJE
 | | Crystal structure of DHODH in complex with ferulenol from Eimeria tenella | | 分子名称: | 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | | 著者 | Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S. | | 登録日 | 2018-08-27 | | 公開日 | 2019-08-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Genes (Basel), 11, 2020
|
|
3IHA
 | |
6AJ5
 | | Crystal structure of ligand-free type DHODH from Eimeria tenella | | 分子名称: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S. | | 登録日 | 2018-08-27 | | 公開日 | 2019-08-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Genes (Basel), 11, 2020
|
|
3IH8
 | |
3IH9
 | |
7DVU
 | | Crystal structure of heme sensor protein PefR in complex with heme and cyanide | | 分子名称: | CYANIDE ION, HTH marR-type domain-containing protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Nishinaga, M, Nagai, S, Nishitani, Y, Sugimoto, H, Shiro, Y, Sawai, H. | | 登録日 | 2021-01-15 | | 公開日 | 2021-09-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival.
Commun Biol, 4, 2021
|
|
7DVT
 | | Crystal structure of heme sensor protein PefR in complex with heme and carbon monoxide | | 分子名称: | CARBON MONOXIDE, HTH marR-type domain-containing protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Nishinaga, M, Nagai, S, Nishitani, Y, Sugimoto, H, Shiro, Y, Sawai, H. | | 登録日 | 2021-01-15 | | 公開日 | 2021-09-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival.
Commun Biol, 4, 2021
|
|
7DVR
 | | Crystal structure of heme sensor protein PefR from Streptococcus agalactiae in complex with heme | | 分子名称: | COBALT (II) ION, HTH marR-type domain-containing protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Nishinaga, M, Nagai, S, Nishitani, Y, Sugimoto, H, Shiro, Y, Sawai, H. | | 登録日 | 2021-01-15 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival.
Commun Biol, 4, 2021
|
|
8X6R
 | | KRasG12C in complex with inhibitor | | 分子名称: | 1-[7-[6-ethenyl-8-ethoxy-7-(5-methyl-1~{H}-indazol-4-yl)-2-(1-methylpiperidin-4-yl)oxy-quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | | 著者 | Amano, Y, Tateishi, Y. | | 登録日 | 2023-11-21 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
Bioorg.Med.Chem., 98, 2023
|
|
7FBH
 | | geranyl pyrophosphate C6-methyltransferase BezA | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BezA, ... | | 著者 | Tsutsumi, H, Moriwaki, Y, Terada, T, Shimizu, K, Katsuyama, Y, Ohnishi, Y. | | 登録日 | 2021-07-10 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6-Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6-Methyltransferase.
Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
7FBO
 | | geranyl pyrophosphate C6-methyltransferase BezA binding with S-adenosylhomocysteine | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BezA, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Tsutsumi, H, Moriwaki, Y, Terada, T, Shimizu, K, Katsuyama, Y, Ohnishi, Y. | | 登録日 | 2021-07-12 | | 公開日 | 2021-12-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6-Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6-Methyltransferase.
Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
5AX6
 | | The crystal structure of CofB, the minor pilin subunit of CFA/III from human enterotoxigenic Escherichia coli. | | 分子名称: | ACETATE ION, CofB | | 著者 | Kawahara, K, Oki, K, Fukaksua, F, Maruno, T, Kobayashi, Y, Daisuke, M, Taniguchi, T, Honda, T, Iida, T, Nakamura, S, Ohkubo, T. | | 登録日 | 2015-07-16 | | 公開日 | 2016-03-09 | | 最終更新日 | 2020-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Homo-trimeric Structure of the Type IVb Minor Pilin CofB Suggests Mechanism of CFA/III Pilus Assembly in Human Enterotoxigenic Escherichia coli
J.Mol.Biol., 428, 2016
|
|
5AYJ
 | | Hyperthermostable mutant of Bacillus sp. TB-90 Urate Oxidase - R298C | | 分子名称: | 9-METHYL URIC ACID, HEXAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Hibi, T, Kume, A, Kawamura, A, Itoh, T, Nishiya, Y. | | 登録日 | 2015-08-21 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Hyperstabilization of Tetrameric Bacillus sp. TB-90 Urate Oxidase by Introducing Disulfide Bonds through Structural Plasticity
Biochemistry, 55, 2016
|
|
6L2F
 | | Crystal structure of a cupin protein (tm1459, H54AH58A mutant) in copper (Cu) substituted form | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, COPPER (II) ION, ... | | 著者 | Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes.
Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
5ZS9
 | |
6L2D
 | | Crystal structure of a cupin protein (tm1459) in copper (Cu) substituted form | | 分子名称: | COPPER (II) ION, Cupin_2 domain-containing protein | | 著者 | Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.198 Å) | | 主引用文献 | Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes.
Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
1IS1
 | | Crystal structure of ribosome recycling factor from Vibrio parahaemolyticus | | 分子名称: | RIBOSOME RECYCLING FACTOR | | 著者 | Nakano, H, Yamaichi, Y, Uchiyama, S, Yoshida, T, Nishina, K, Kato, H, Ohkubo, T, Honda, T, Yamagata, Y, Kobayashi, Y. | | 登録日 | 2001-11-05 | | 公開日 | 2003-06-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure and binding mode of a ribosome recycling factor (RRF) from mesophilic bacterium
J.BIOL.CHEM., 278, 2003
|
|
6L2E
 | | Crystal structure of a cupin protein (tm1459, H52A mutant) in copper (Cu) substituted form | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COPPER (II) ION, Cupin_2 domain-containing protein | | 著者 | Fujieda, N, Ichihashi, H, Nishikawa, Y, Kurisu, G, Itoh, S. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.201 Å) | | 主引用文献 | Cupin Variants as a Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes.
Angew.Chem.Int.Ed.Engl., 59, 2020
|
|
2Z6W
 | | Crystal structure of human cyclophilin D in complex with cyclosporin A | | 分子名称: | CITRIC ACID, CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE | | 著者 | Kajitani, K, Fujihashi, M, Kobayashi, Y, Shimizu, S, Tsujimoto, Y, Miki, K. | | 登録日 | 2007-08-09 | | 公開日 | 2008-04-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (0.96 Å) | | 主引用文献 | Crystal Structure of Human Cyclophilin D in Complex with its Inhibitor, Cyclosporin a at 0.96-A Resolution.
Proteins, 70, 2008
|
|
6IOP
 | | The ligand binding domain of Mlp24 | | 分子名称: | ACETATE ION, ALANINE, CALCIUM ION, ... | | 著者 | Sumita, K, Takahashi, Y, Nishiyama, S, Kawagishi, I, Imada, K. | | 登録日 | 2018-10-31 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae.
J. Bacteriol., 201, 2019
|
|
6LVL
 | | Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative | | 分子名称: | Fibroblast growth factor receptor 2, N-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide, SULFATE ION | | 著者 | Echizen, Y, Tateishi, Y, Amano, Y. | | 登録日 | 2020-02-04 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.
Bioorg.Med.Chem., 28, 2020
|
|
2ROK
 | | Solution structure of the cap-binding domain of PARN complexed with the cap analog | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, poly(A)-specific ribonuclease | | 著者 | Nagata, T, Suzuki, S, Endo, R, Shirouzu, M, Terada, T, Inoue, M, Kigawa, T, Guntert, P, Hayashizaki, Y, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2008-03-28 | | 公開日 | 2009-02-10 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition.
Nucleic Acids Res., 36, 2008
|
|
5ZSO
 | | SufS from Bacillus subtilis, soaked with L-cysteine for 90 sec | | 分子名称: | Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-CYSTEINE | | 著者 | Nakamura, R, Fujishiro, T, Takahashi, Y. | | 登録日 | 2018-04-29 | | 公開日 | 2019-05-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes.
Febs J., 287, 2020
|
|
6IDJ
 | | Crystal structure of human DHODH in complex with ferulenol | | 分子名称: | 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S. | | 登録日 | 2018-09-10 | | 公開日 | 2019-09-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Genes (Basel), 11, 2020
|
|
