5JSB
| Crystal structure of Mcl1-inhibitor complex | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2016-05-07 | Release date: | 2016-11-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
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4QQ8
| Crystal structure of the formolase FLS in space group P 43 21 2 | Descriptor: | 1,2-ETHANEDIOL, Formolase, MAGNESIUM ION, ... | Authors: | Shen, B.W, Siegel, J.B, Stoddard, B.L. | Deposit date: | 2014-06-26 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Computational protein design enables a novel one-carbon assimilation pathway. Proc.Natl.Acad.Sci.USA, 112, 2015
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4R6G
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4R58
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4R5D
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4R5C
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1B0A
| 5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI. | Descriptor: | PROTEIN (FOLD BIFUNCTIONAL PROTEIN) | Authors: | Shen, B.W, Dyer, D, Huang, J.-Y, D'Ari, L, Rabinowitz, J, Stoddard, B.L. | Deposit date: | 1998-11-06 | Release date: | 1999-06-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase. Protein Sci., 8, 1999
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4R6F
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5E63
| K262A mutant of I-SmaMI | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-METHOXYETHANOL, DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ... | Authors: | Shen, B, Stoddard, B. | Deposit date: | 2015-10-09 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J.Mol.Biol., 428, 2016
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5JSN
| Bcl2-inhibitor complex | Descriptor: | Apoptosis regulator Bcl-2, Bcl2 inhibitor | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2016-05-09 | Release date: | 2016-11-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
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1OAT
| ORNITHINE AMINOTRANSFERASE | Descriptor: | ORNITHINE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Shen, B.W, Schirmer, T, Jansonius, J.N. | Deposit date: | 1997-03-26 | Release date: | 1998-04-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human recombinant ornithine aminotransferase. J.Mol.Biol., 277, 1998
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5E5O
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5E67
| K103A/K262A double mutant of I-SmaMI | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-METHOXYETHANOL, DNA bottom strand, ... | Authors: | Shen, B.W, Stoddard, B. | Deposit date: | 2015-10-09 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J.Mol.Biol., 428, 2016
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5E5S
| I-SmaMI K103A mutant | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, Bottom strand DNA, DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ... | Authors: | Shen, B.W. | Deposit date: | 2015-10-09 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J.Mol.Biol., 428, 2016
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5E5P
| Wild type I-SmaMI in the space group of C121 | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, I-SmaMI LAGLIDADG meganuclease | Authors: | Shen, B.W. | Deposit date: | 2015-10-09 | Release date: | 2016-01-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J.Mol.Biol., 428, 2016
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1Q33
| Crystal structure of human ADP-ribose pyrophosphatase NUDT9 | Descriptor: | ADP-ribose pyrophosphatase, SULFATE ION, beta-D-glucopyranose | Authors: | Shen, B.W, Perraud, A.L, Scharenberg, A, Stoddard, B.L. | Deposit date: | 2003-07-28 | Release date: | 2003-09-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | The Crystal Structure and Mutational Analysis of Human NUDT9 J.Mol.Biol., 332, 2003
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1QVJ
| structure of NUDT9 complexed with ribose-5-phosphate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-O-phosphono-beta-D-ribofuranose, ADP-ribose pyrophosphatase, ... | Authors: | Shen, B.W, Perraud, A.-L, Scharenberg, A.S, Stoddard, B.L. | Deposit date: | 2003-08-27 | Release date: | 2003-09-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | The crystal structure and mutational analysis of human NUDT9 J.Mol.Biol., 332, 2003
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7RDR
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6EG7
| BbvCI B2 dimer with I3C clusters | Descriptor: | 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, BbvCI endonuclease subunit 2, ... | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2018-08-19 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI. Nucleic Acids Res., 47, 2019
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5TH3
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5TGX
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5TGQ
| Restriction-modification system Type II R.SwaI, DNA free | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Shen, B.W, stoddard, B.L. | Deposit date: | 2016-09-28 | Release date: | 2016-12-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target. Nucleic Acids Res., 45, 2017
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1U3E
| DNA binding and cleavage by the HNH homing endonuclease I-HmuI | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 36-MER, ... | Authors: | Shen, B.W, Landthaler, M, Shub, D.A, Stoddard, B.L. | Deposit date: | 2004-07-21 | Release date: | 2004-08-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | DNA Binding and Cleavage by the HNH Homing Endonuclease I-HmuI. J.Mol.Biol., 342, 2004
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4OYD
| Crystal structure of a computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein | Descriptor: | 1,2-ETHANEDIOL, Apoptosis regulator BHRF1, Computationally designed Inhibitor | Authors: | Shen, B, Procko, E, Baker, D, Stoddard, B. | Deposit date: | 2014-02-11 | Release date: | 2014-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells. Cell, 157, 2014
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3LDY
| An extraordinary mechanism of DNA perturbation exhibited by the rare-cutting HNH restriction endonuclease PacI | Descriptor: | CALCIUM ION, DNA (5'-D(*GP*AP*GP*GP*CP*TP*TP*A)-3'), DNA (5'-D(P*AP*TP*TP*AP*AP*GP*CP*CP*TP*C)-3'), ... | Authors: | Shen, B.W, Heiter, D, Chan, S.-H, Xu, S.-Y, Wilson, G, Stoddard, B.L. | Deposit date: | 2010-01-13 | Release date: | 2010-04-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI. Structure, 18, 2010
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